AR080108A1 - A STABLE PHARMACEUTICAL COMPOSITION OF ORAL ADMINISTRATION THAT INCLUDES 4-AMINO-1 - [(2R, 5S) -2- (HYDROXIMETHYL) -1,3-OXATIOLAN-5-IL] -1,2-DIHYDROPIRIMIDINE-2-ONA, ACID ({[(2R) -1- (6-AMINO-9H-PURINA-9-IL) PROPAN-2-IL] OXI} METHYL) PHOSPHORIC AND 8-CHLORINE-5- (2-CYCLOPROPYLETINYL) -5- (TRIFLUOROMETIL ) -4-OXA-2-AZABICI - Google Patents

A STABLE PHARMACEUTICAL COMPOSITION OF ORAL ADMINISTRATION THAT INCLUDES 4-AMINO-1 - [(2R, 5S) -2- (HYDROXIMETHYL) -1,3-OXATIOLAN-5-IL] -1,2-DIHYDROPIRIMIDINE-2-ONA, ACID ({[(2R) -1- (6-AMINO-9H-PURINA-9-IL) PROPAN-2-IL] OXI} METHYL) PHOSPHORIC AND 8-CHLORINE-5- (2-CYCLOPROPYLETINYL) -5- (TRIFLUOROMETIL ) -4-OXA-2-AZABICI

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Publication number
AR080108A1
AR080108A1 ARP110100345A AR080108A1 AR 080108 A1 AR080108 A1 AR 080108A1 AR P110100345 A ARP110100345 A AR P110100345A AR 080108 A1 AR080108 A1 AR 080108A1
Authority
AR
Argentina
Prior art keywords
amino
propan
oxa
phosphoric
methyl
Prior art date
Application number
Other languages
English (en)
Original Assignee
Lkm S A Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lkm S A Lab filed Critical Lkm S A Lab
Priority to ARP110100345 priority Critical patent/AR080108A1/es
Publication of AR080108A1 publication Critical patent/AR080108A1/es

Links

Abstract

Una composicion farmacéutica estable de administracion oral en forma de una unica unidad de dosis caracterizada porque comprende un nucleosido inhibidor de la transcriptasa reversa, un nucleotido inhibidor de la transcriptasa reversa, un inhibidor de la transcriptasa reversa no nucleosídico y uno o más excipientes farmacéuticamente aceptables. Un procedimiento para la fabricacion de un comprimido multigranulado recubierto. El uso de la combinacion de 4-amino-1-[(2R,5S)-2-(hidroximetil)-1,3-oxatiolan-5-il]-1,2-dihidropirimidina-2-ona, acido ({[(2R)-1-(6-amino-9H-purina-9-il)propan-2-il]oxi}metil) fosforico y 8-cloro-5-(2-ciclopropiletinil)-5- (trifluorometil)-4-oxa-2-azabiciclo[4.4.0] deca-7,9,11-trien-3-ona para la manufactura de un medicamento para el tratamiento de infecciones virales, particularmente infecciones retrovirales que incluye el virus de inmunodeficiencia humana (HIV) o prevencion de los síntomas o efectos de una infeccion por HIV o consecuencia de la misma, en un individuo infectado. Un método de tratamiento que lo utiliza.A stable pharmaceutical composition for oral administration in the form of a single dose unit characterized in that it comprises a reverse transcriptase inhibitor nucleoside, a reverse transcriptase inhibitor nucleotide, a non-nucleoside reverse transcriptase inhibitor and one or more pharmaceutically acceptable excipients. A process for the manufacture of a multigranulated coated tablet. The use of the combination of 4-amino-1 - [(2R, 5S) -2- (hydroxymethyl) -1,3-oxathiolan-5-yl] -1,2-dihydropyrimidine-2-one, acid ({[ (2R) -1- (6-amino-9H-purine-9-yl) propan-2-yl] oxy} methyl) phosphoric and 8-chloro-5- (2-cyclopropylethynyl) -5- (trifluoromethyl) -4 -oxa-2-azabicyclo [4.4.0] deca-7,9,11-trien-3-one for the manufacture of a medicament for the treatment of viral infections, particularly retroviral infections including human immunodeficiency virus (HIV) or prevention of the symptoms or effects of an HIV infection or consequence thereof, in an infected individual. A treatment method that uses it.
ARP110100345 2011-02-01 2011-02-01 A STABLE PHARMACEUTICAL COMPOSITION OF ORAL ADMINISTRATION THAT INCLUDES 4-AMINO-1 - [(2R, 5S) -2- (HYDROXIMETHYL) -1,3-OXATIOLAN-5-IL] -1,2-DIHYDROPIRIMIDINE-2-ONA, ACID ({[(2R) -1- (6-AMINO-9H-PURINA-9-IL) PROPAN-2-IL] OXI} METHYL) PHOSPHORIC AND 8-CHLORINE-5- (2-CYCLOPROPYLETINYL) -5- (TRIFLUOROMETIL ) -4-OXA-2-AZABICI AR080108A1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ARP110100345 AR080108A1 (es) 2011-02-01 2011-02-01 A STABLE PHARMACEUTICAL COMPOSITION OF ORAL ADMINISTRATION THAT INCLUDES 4-AMINO-1 - [(2R, 5S) -2- (HYDROXIMETHYL) -1,3-OXATIOLAN-5-IL] -1,2-DIHYDROPIRIMIDINE-2-ONA, ACID ({[(2R) -1- (6-AMINO-9H-PURINA-9-IL) PROPAN-2-IL] OXI} METHYL) PHOSPHORIC AND 8-CHLORINE-5- (2-CYCLOPROPYLETINYL) -5- (TRIFLUOROMETIL ) -4-OXA-2-AZABICI

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ARP110100345 AR080108A1 (es) 2011-02-01 2011-02-01 A STABLE PHARMACEUTICAL COMPOSITION OF ORAL ADMINISTRATION THAT INCLUDES 4-AMINO-1 - [(2R, 5S) -2- (HYDROXIMETHYL) -1,3-OXATIOLAN-5-IL] -1,2-DIHYDROPIRIMIDINE-2-ONA, ACID ({[(2R) -1- (6-AMINO-9H-PURINA-9-IL) PROPAN-2-IL] OXI} METHYL) PHOSPHORIC AND 8-CHLORINE-5- (2-CYCLOPROPYLETINYL) -5- (TRIFLUOROMETIL ) -4-OXA-2-AZABICI

Publications (1)

Publication Number Publication Date
AR080108A1 true AR080108A1 (es) 2012-03-14

Family

ID=45830843

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP110100345 AR080108A1 (es) 2011-02-01 2011-02-01 A STABLE PHARMACEUTICAL COMPOSITION OF ORAL ADMINISTRATION THAT INCLUDES 4-AMINO-1 - [(2R, 5S) -2- (HYDROXIMETHYL) -1,3-OXATIOLAN-5-IL] -1,2-DIHYDROPIRIMIDINE-2-ONA, ACID ({[(2R) -1- (6-AMINO-9H-PURINA-9-IL) PROPAN-2-IL] OXI} METHYL) PHOSPHORIC AND 8-CHLORINE-5- (2-CYCLOPROPYLETINYL) -5- (TRIFLUOROMETIL ) -4-OXA-2-AZABICI

Country Status (1)

Country Link
AR (1) AR080108A1 (es)

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