AR064749A1 - Utilizacion de compuestos neuroprotectores para la obtencion de medicamentos destinados al tratamiento de enfermedades neurodegenerativas - Google Patents
Utilizacion de compuestos neuroprotectores para la obtencion de medicamentos destinados al tratamiento de enfermedades neurodegenerativasInfo
- Publication number
- AR064749A1 AR064749A1 ARP080100031A ARP080100031A AR064749A1 AR 064749 A1 AR064749 A1 AR 064749A1 AR P080100031 A ARP080100031 A AR P080100031A AR P080100031 A ARP080100031 A AR P080100031A AR 064749 A1 AR064749 A1 AR 064749A1
- Authority
- AR
- Argentina
- Prior art keywords
- branched
- linear
- optionally substituted
- alkoxy
- diseases
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Utilizacion de compuestos neuroprotectores para la obtencion de medicamentos destinados al tratamiento curativo de enfermedades neurodegenerativas y/o la prevencion de la aparicion de los trastornos inducidos por estas enfermedades. Reivindicacion 1: Utilizacion de compuestos de formula (1) en el tratamiento curativo de enfermedades neurodegenerativas y/o la prevencion de la aparicion de los trastornos inducidos por estas enfermedades, en la que R1, R2, R3, R4, idénticos o diferentes, independientemente los unos de los otros, representan un átomo de hidrogeno o de halogeno, un grupo hidroxi, alquilo C1-6 lineal o ramificado sustituido opcionalmente con uno o varios átomos de halogeno, grupos amino, nitro, alcoxi C1-6 lineal o ramificado, arilo sustituido opcionalmente, alcoxi C1-6 lineal o ramificado sustituido opcionalmente con uno o varios átomos de halogeno, grupos amino, nitro, alcoxi C1-6 lineal o ramificada o R1, R2, R3 y R4, tomados dos a dos y unidos a átomos de carbono adyacentes, forman un grupo metilendioxi o etilendioxi, R6 y R7 representan cada uno un átomo de hidrogeno adoptando una configuracion cis uno respecto al otro o formando juntos un enlace, R8 y R9 representan cada uno un átomo de hidrogeno adoptando una configuracion cis o trans uno respecto al otro o formando juntos un enlace en el caso en el que R6 y R7 forman juntos un enlace, A representa un radical bivalente de formulas (2), Z representa un átomo de oxígeno o de azufre; R5 representa un átomo de hidrogeno o un grupo alquilo C1-6 lineal o ramificado sustituido opcionalmente con uno o varios átomos de halogeno, grupos alcoxi C1-6 lineales o ramificados, -NR10R11, fenilo sustituido opcionalmente con uno o varios átomos de halogeno, grupos alquilos C1-6 lineales o ramificados o alcoxi C1-6 lineales o ramificados, estando estos radicales alquilos o alcoxi sustituidos opcionalmente con uno o varios arilos sustituidos opcionalmente, R10 y R11, idénticos o diferentes, independientemente el uno del otro, representan un átomo de hidrogeno o un grupo alquilo C1-6 lineal o ramificado o alcoxi C1-6 lineal o ramificado, sus enantiomeros y diastereoisomeros así como sus sales de adicion a un ácido o a una base aceptables farmacéuticamente. Reivindicacion 6: Utilizacion de N-(1H-indol-1-il)-N'-(3-piridinil]urea o N-(2,3-dihidro-1 H-indol-1-il)-N'-(3-piridinil)urea, o sus sales de adicion a un ácido o a una base aceptable farmacéuticamente en el tratamiento curativo de enfermedades neurodegenerativas y/o la prevencion de la aparicion de los trastornos inducidos por estas enfermedades.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0700048A FR2911143A1 (fr) | 2007-01-05 | 2007-01-05 | Utilisation de composes neuroprotecteurs pour l'obtention de medicaments destines au traitement de maladies neurodegeneratives. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR064749A1 true AR064749A1 (es) | 2009-04-22 |
Family
ID=38309971
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080100031A AR064749A1 (es) | 2007-01-05 | 2008-01-04 | Utilizacion de compuestos neuroprotectores para la obtencion de medicamentos destinados al tratamiento de enfermedades neurodegenerativas |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20090298813A1 (es) |
| EP (1) | EP2101768A2 (es) |
| JP (1) | JP2010514827A (es) |
| KR (1) | KR20090104853A (es) |
| CN (1) | CN101578100A (es) |
| AR (1) | AR064749A1 (es) |
| AU (1) | AU2008214550A1 (es) |
| BR (1) | BRPI0806275A2 (es) |
| CA (1) | CA2674100A1 (es) |
| EA (1) | EA200900923A1 (es) |
| FR (1) | FR2911143A1 (es) |
| MA (1) | MA31032B1 (es) |
| MX (1) | MX2009007198A (es) |
| WO (1) | WO2008099083A2 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2926077A1 (fr) * | 2008-01-04 | 2009-07-10 | Servier Lab | Nouveaux derives d'1h-indol-1-yl uree, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| JP6154282B2 (ja) * | 2013-10-03 | 2017-06-28 | 株式会社ファンケル | 神経幹細胞又は神経前駆細胞の増殖促進剤 |
| CN111018802B (zh) * | 2019-12-03 | 2021-07-06 | 湖北大学 | 具有抗帕金森氏症的化合物、制备方法及其应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA786426B (en) * | 1977-11-25 | 1979-10-31 | Scras | New indulo(2,3-a)quinolizidines,preparation and therapeutic use |
| FR2713644B1 (fr) * | 1993-12-14 | 1996-02-09 | Adir | Nouveaux analogues de l'éburnane, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
| DK1470818T3 (da) * | 2003-04-25 | 2006-11-20 | Neuro3D | Anvendelse af Piperazin-phenothiazin-derivater til fremstilling af et medikament med neurobeskyttende og/eller neurotrofiske effekter på CNS og/eller PNS |
| CN1566099A (zh) * | 2003-06-13 | 2005-01-19 | 中国科学院上海药物研究所 | 异喹啉－1,3,4－三酮类化合物、制备方法及其用途 |
-
2007
- 2007-01-05 FR FR0700048A patent/FR2911143A1/fr not_active Withdrawn
-
2008
- 2008-01-04 US US12/448,719 patent/US20090298813A1/en not_active Abandoned
- 2008-01-04 BR BRPI0806275-7A patent/BRPI0806275A2/pt not_active IP Right Cessation
- 2008-01-04 WO PCT/FR2008/000014 patent/WO2008099083A2/fr active Application Filing
- 2008-01-04 AR ARP080100031A patent/AR064749A1/es unknown
- 2008-01-04 MX MX2009007198A patent/MX2009007198A/es not_active Application Discontinuation
- 2008-01-04 EP EP08761738A patent/EP2101768A2/fr not_active Withdrawn
- 2008-01-04 EA EA200900923A patent/EA200900923A1/ru unknown
- 2008-01-04 JP JP2009544434A patent/JP2010514827A/ja active Pending
- 2008-01-04 AU AU2008214550A patent/AU2008214550A1/en not_active Abandoned
- 2008-01-04 CA CA002674100A patent/CA2674100A1/fr not_active Abandoned
- 2008-01-04 CN CNA2008800017537A patent/CN101578100A/zh active Pending
- 2008-01-04 KR KR1020097016380A patent/KR20090104853A/ko not_active Application Discontinuation
-
2009
- 2009-06-29 MA MA32053A patent/MA31032B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2009007198A (es) | 2009-08-12 |
| CN101578100A (zh) | 2009-11-11 |
| WO2008099083A2 (fr) | 2008-08-21 |
| WO2008099083A3 (fr) | 2008-12-11 |
| EP2101768A2 (fr) | 2009-09-23 |
| FR2911143A1 (fr) | 2008-07-11 |
| BRPI0806275A2 (pt) | 2011-09-06 |
| CA2674100A1 (fr) | 2008-08-21 |
| KR20090104853A (ko) | 2009-10-06 |
| JP2010514827A (ja) | 2010-05-06 |
| AU2008214550A1 (en) | 2008-08-21 |
| US20090298813A1 (en) | 2009-12-03 |
| EA200900923A1 (ru) | 2009-12-30 |
| MA31032B1 (fr) | 2009-12-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |