AR057636A2 - Procedimiento para preparar una composicion farmaceutica que contiene ibandronato en forma de dosificacion unitaria - Google Patents

Procedimiento para preparar una composicion farmaceutica que contiene ibandronato en forma de dosificacion unitaria

Info

Publication number
AR057636A2
AR057636A2 ARP070100583A ARP070100583A AR057636A2 AR 057636 A2 AR057636 A2 AR 057636A2 AR P070100583 A ARP070100583 A AR P070100583A AR P070100583 A ARP070100583 A AR P070100583A AR 057636 A2 AR057636 A2 AR 057636A2
Authority
AR
Argentina
Prior art keywords
pharmaceutical composition
composition containing
ibandronate
prepare
procedure
Prior art date
Application number
ARP070100583A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR057636A2 publication Critical patent/AR057636A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis

Abstract

Un procedimiento para preparar una composicion farmacéutica que contiene ibandronato en forma de dosificacion unitaria, conteniendo dicha composicion hasta 50 mg. de ibandronato por dosis unitaria, que comprende granular el ibandronato en presencia de agua en un granulador de lecho fluidificado con adyuvantes para formar un granulado; secar el granulado en el granulador de lecho fluidificado; y procesar el granulado para producir la composicion farmacéutica en forma de dosificacion unitaria, en donde los adyuvantes comprenden lactosa en una cantidad de aproximadamente 25 a aproximadamente 75% en peso de la composicion, celulosa microcristalina en una cantidad de aproximadamente 10 a aproximadamente 20% en peso de la composicion, y polivinil pirrolidona en una cantidad de aproximadamente 2 a aproximadamente 3% en peso de la composicion.
ARP070100583A 1998-10-09 2007-02-12 Procedimiento para preparar una composicion farmaceutica que contiene ibandronato en forma de dosificacion unitaria AR057636A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98119103A EP0998933A1 (de) 1998-10-09 1998-10-09 Verfahren zur Herstellung von bisphosphonathaltigen pharmazeutischen Zusammensetzungen zur oralen Applikation

Publications (1)

Publication Number Publication Date
AR057636A2 true AR057636A2 (es) 2007-12-12

Family

ID=8232770

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP990105082A AR019242A1 (es) 1998-10-09 1999-10-07 Procedimiento para composiciones farmaceuticas por via oral
ARP070100583A AR057636A2 (es) 1998-10-09 2007-02-12 Procedimiento para preparar una composicion farmaceutica que contiene ibandronato en forma de dosificacion unitaria

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP990105082A AR019242A1 (es) 1998-10-09 1999-10-07 Procedimiento para composiciones farmaceuticas por via oral

Country Status (16)

Country Link
US (1) US6419955B1 (es)
EP (2) EP0998933A1 (es)
JP (1) JP3725427B2 (es)
KR (1) KR100496086B1 (es)
CN (1) CN1154498C (es)
AR (2) AR019242A1 (es)
AT (1) ATE314075T1 (es)
AU (1) AU744142B2 (es)
BR (1) BR9914368A (es)
CA (1) CA2345818C (es)
DE (1) DE69929219T2 (es)
DK (1) DK1117411T3 (es)
ES (1) ES2255301T3 (es)
TR (1) TR200100888T2 (es)
WO (1) WO2000021541A1 (es)
ZA (1) ZA200102273B (es)

Families Citing this family (77)

* Cited by examiner, † Cited by third party
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EP0998932A1 (de) 1998-10-09 2000-05-10 Boehringer Mannheim Gmbh Feste pharmazeutische Darreichungsform enthaltend Diphosphonsäure oder deren Salze und Verfahren zu ihrer Herstellung
CZ2004690A3 (cs) * 2001-12-21 2004-09-15 The Procter & Gamble Company Souprava a způsob jejího použití k léčbě kostních chorob
DK1880744T3 (en) * 2002-05-10 2015-02-09 Hoffmann La Roche Bisphosphonic acids for the treatment and prevention of osteoporosis
US20050026871A1 (en) * 2002-07-17 2005-02-03 Moshe Flashner-Barak Method of increasing bioavailability of alendronate or other bis-phosphonate by predose administration of vitamin D derivative
PL212072B1 (pl) 2002-12-20 2012-08-31 Hoffmann La Roche Tabletka zawierająca jako substancję czynną do 250 mg kwasu ibandronowego oraz sposób jej wytwarzania
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MX2007000087A (es) * 2004-06-23 2007-11-06 Teva Pharma Acido ibandronico solido y cristalino.
ATE495747T1 (de) * 2004-08-23 2011-02-15 Teva Pharma Kristalline form des ibandronat-natriums und herstellungsverfahren dafür
US20070191315A1 (en) * 2006-02-16 2007-08-16 Bengt Bergstrom Method for administering ibandronate
CA2661616A1 (en) * 2006-08-24 2008-02-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Process for preparing pramipexole dihydrochloride tablets
GB0616794D0 (en) * 2006-08-24 2006-10-04 Arrow Int Ltd Solid dosage form
JPWO2009069280A1 (ja) * 2007-11-27 2011-04-07 大原薬品工業株式会社 造粒物の製造法
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WO2011014766A2 (en) 2009-07-31 2011-02-03 Thar Pharmaceuticals, Inc. Crystallization method and bioavailability
US20160016982A1 (en) 2009-07-31 2016-01-21 Thar Pharmaceuticals, Inc. Crystallization method and bioavailability
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US9789128B2 (en) 2012-05-14 2017-10-17 Antecip Bioventures Ii Llc Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome
US10039773B2 (en) 2012-05-14 2018-08-07 Antecip Bioventures Ii Llc Neridronic acid for treating arthritis
US9925203B2 (en) 2012-05-14 2018-03-27 Antecip Bioventures Ii Llc Compositions for administration of zoledronic acid or related compounds for treating low back pain
US9675626B2 (en) 2012-05-14 2017-06-13 Antecip Bioventures Ii Llc Compositions for oral administration of zoledronic acid or related compounds for treating complex regional pain syndrome
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US9770457B2 (en) 2012-05-14 2017-09-26 Antecip Bioventures Ii Llc Neridronic acid for treating bone marrow lesion
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US9844559B2 (en) 2012-05-14 2017-12-19 Antecip Bioventures Ii Llc Neridronic acid for treating bone marrow lesions
US9782421B1 (en) 2012-05-14 2017-10-10 Antecip Bioventures Ii Llc Neridronic acid molecular complex for treating complex regional pain syndrome
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US9956237B2 (en) 2012-05-14 2018-05-01 Antecip Bioventures Ii Llc Osteoclast inhibitors for knee conditions
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US10350227B2 (en) 2012-05-14 2019-07-16 Antecip Bioventures Ii Llc Neridronic acid for treating complex regional pain syndrome
US9861648B2 (en) 2012-05-14 2018-01-09 Antecip Boiventures Ii Llc Osteoclast inhibitors for knee conditions
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Also Published As

Publication number Publication date
JP2002527399A (ja) 2002-08-27
CA2345818C (en) 2006-01-03
EP0998933A1 (de) 2000-05-10
WO2000021541A1 (en) 2000-04-20
ATE314075T1 (de) 2006-01-15
EP1117411A1 (en) 2001-07-25
AR019242A1 (es) 2001-12-26
DE69929219D1 (de) 2006-02-02
CN1154498C (zh) 2004-06-23
AU744142B2 (en) 2002-02-14
AU6199099A (en) 2000-05-01
CA2345818A1 (en) 2000-04-20
DK1117411T3 (da) 2006-04-24
TR200100888T2 (tr) 2001-07-23
US6419955B1 (en) 2002-07-16
KR20010073202A (ko) 2001-07-31
DE69929219T2 (de) 2006-08-17
ZA200102273B (en) 2002-06-19
CN1319016A (zh) 2001-10-24
ES2255301T3 (es) 2006-06-16
KR100496086B1 (ko) 2005-06-20
JP3725427B2 (ja) 2005-12-14
EP1117411B1 (en) 2005-12-28
BR9914368A (pt) 2001-08-07

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