AR052301A1 - Procedimiento de preparacion de un monoclorhidrato. formas cristalinas y composiciones farmaceuticas - Google Patents
Procedimiento de preparacion de un monoclorhidrato. formas cristalinas y composiciones farmaceuticasInfo
- Publication number
- AR052301A1 AR052301A1 ARP050101278A ARP050101278A AR052301A1 AR 052301 A1 AR052301 A1 AR 052301A1 AR P050101278 A ARP050101278 A AR P050101278A AR P050101278 A ARP050101278 A AR P050101278A AR 052301 A1 AR052301 A1 AR 052301A1
- Authority
- AR
- Argentina
- Prior art keywords
- compound
- formula
- preparation
- pharmaceutical compositions
- crystal forms
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Formas cristalinas y composiciones farmacéuticas. Reivindicacion 1: Un procedimiento para la preparacion de una sal monoclorhidrato del compuesto de formula (1), en la que *C y **C denota átomos de carbono asimétricos, tal procedimiento comprende las etapas de: a) poner en contacto un compuesto de formula (2), en la que P1 representa un grupo protector de hidroxilo, y P2 y P3 representa cada uno independientemente hidrogeno o un grupo protector; con un ácido débil, para efectuar la protonacion selectiva; b) poner en contacto el producto de a) con una fuente de iones cloruro para efectuar el intercambio de aniones; c) desproteccion para eliminar P1, y cuando sea necesario P2 y P3; d) aislamiento del compuesto de formula (1) como el monoclorhidrato; y de forma opcional; e) cristalizacion o recristalizacion del compuesto de formula (1).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0407521A GB0407521D0 (en) | 2004-04-02 | 2004-04-02 | Chemical process |
GB0411688A GB0411688D0 (en) | 2004-05-25 | 2004-05-25 | Chemical process |
US57446704P | 2004-05-26 | 2004-05-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR052301A1 true AR052301A1 (es) | 2007-03-14 |
Family
ID=34963396
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP050101278A AR052301A1 (es) | 2004-04-02 | 2005-03-31 | Procedimiento de preparacion de un monoclorhidrato. formas cristalinas y composiciones farmaceuticas |
Country Status (13)
Country | Link |
---|---|
US (1) | US7846973B2 (es) |
EP (1) | EP1730104A1 (es) |
JP (1) | JP2007530652A (es) |
AR (1) | AR052301A1 (es) |
AU (1) | AU2005227733A1 (es) |
BR (1) | BRPI0509382A (es) |
CA (1) | CA2561400A1 (es) |
IL (1) | IL178064A0 (es) |
MA (1) | MA28558B1 (es) |
NO (1) | NO20064884L (es) |
PE (1) | PE20060678A1 (es) |
TW (1) | TW200536814A (es) |
WO (1) | WO2005095328A1 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006066907A1 (en) * | 2004-12-21 | 2006-06-29 | Glaxo Group Limited | Pharmaceutical formulations |
GB0601951D0 (en) | 2006-01-31 | 2006-03-15 | Novartis Ag | Organic compounds |
BRPI0906838A2 (pt) | 2008-01-11 | 2015-07-14 | Novartis Ag | Pirimidinas como inibidores de quinase |
WO2011061527A1 (en) | 2009-11-17 | 2011-05-26 | Astrazeneca Ab | Combinations comprising a glucocorticoid receptor modulator for the treatment of respiratory diseases |
IT1399912B1 (it) * | 2010-04-29 | 2013-05-09 | Lundbeck Pharmaceuticals Italy S Pa | Processo di preparazione di ritodrina cloridrato. |
JP5645762B2 (ja) * | 2010-06-29 | 2014-12-24 | 日本ポリプロ株式会社 | ポリオレフィンの結晶性分布分析方法およびその装置 |
WO2012034095A1 (en) | 2010-09-09 | 2012-03-15 | Irm Llc | Compounds and compositions as trk inhibitors |
US8637516B2 (en) | 2010-09-09 | 2014-01-28 | Irm Llc | Compounds and compositions as TRK inhibitors |
EP2678338B1 (en) | 2011-02-25 | 2015-09-09 | Novartis AG | Pyrazolo[1,5-a]pyridines as trk inhibitors |
GB201212081D0 (en) * | 2012-07-06 | 2012-08-22 | Kalvista Pharmaceuticals Ltd | New polymorph |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CY1308A (en) | 1979-12-06 | 1985-12-06 | Glaxo Group Ltd | Device for dispensing medicaments |
US4353656A (en) * | 1980-10-14 | 1982-10-12 | Xerox Corporation | Moving coil, multiple energy print hammer system including a closed loop servo |
EP0069715B1 (en) | 1981-07-08 | 1986-11-05 | Aktiebolaget Draco | Powder inhalator |
GB2169265B (en) | 1982-10-08 | 1987-08-12 | Glaxo Group Ltd | Pack for medicament |
US4778054A (en) * | 1982-10-08 | 1988-10-18 | Glaxo Group Limited | Pack for administering medicaments to patients |
AT396333B (de) | 1982-10-08 | 1993-08-25 | Glaxo Group Ltd | Vorrichtung zur verabreichung von medikamenten an patienten, einrichtung mit mehreren solchen vorrichtungen und traeger mit medikamentbehaeltern hiefuer |
NL8601949A (nl) * | 1985-07-30 | 1987-02-16 | Glaxo Group Ltd | Inrichtingen voor het toedienen van medicamenten aan patienten. |
GB9004781D0 (en) * | 1990-03-02 | 1990-04-25 | Glaxo Group Ltd | Device |
WO1993019749A1 (en) * | 1992-04-02 | 1993-10-14 | Smithkline Beecham Corporation | Compounds useful for treating allergic and inflammatory diseases |
US5495054A (en) * | 1994-05-31 | 1996-02-27 | Sepracor, Inc. | Tetrahydroindeno[1,2-D][1,3,2]oxazaboroles and their use as enantioselective catalysts |
US6040344A (en) * | 1996-11-11 | 2000-03-21 | Sepracor Inc. | Formoterol process |
GB9700226D0 (en) * | 1997-01-08 | 1997-02-26 | Glaxo Group Ltd | Inhalation device |
OA11558A (en) * | 1999-12-08 | 2004-06-03 | Advanced Medicine Inc | Beta 2-adrenergic receptor agonists. |
UA73965C2 (en) * | 1999-12-08 | 2005-10-17 | Theravance Inc | b2 ADRENERGIC RECEPTOR ANTAGONISTS |
US6632666B2 (en) * | 2000-01-14 | 2003-10-14 | Biolife Solutions, Inc. | Normothermic, hypothermic and cryopreservation maintenance and storage of cells, tissues and organs in gel-based media |
TWI249515B (en) * | 2001-11-13 | 2006-02-21 | Theravance Inc | Aryl aniline beta2 adrenergic receptor agonists |
GB0201677D0 (en) | 2002-01-25 | 2002-03-13 | Glaxo Group Ltd | Medicament dispenser |
TW200409746A (en) | 2002-07-26 | 2004-06-16 | Theravance Inc | Crystalline β2 adrenergic receptor agonist |
ES2331119T3 (es) | 2002-09-16 | 2009-12-22 | Glaxo Group Limited | Compuestos de pirazolo(3,4-b)piridina, y su uso como inhibidores de fosfodiesterasa. |
TW200510277A (en) * | 2003-05-27 | 2005-03-16 | Theravance Inc | Crystalline form of β2-adrenergic receptor agonist |
-
2005
- 2005-03-30 AU AU2005227733A patent/AU2005227733A1/en not_active Abandoned
- 2005-03-30 WO PCT/GB2005/001241 patent/WO2005095328A1/en active Application Filing
- 2005-03-30 US US10/599,145 patent/US7846973B2/en not_active Expired - Fee Related
- 2005-03-30 EP EP05729685A patent/EP1730104A1/en not_active Withdrawn
- 2005-03-30 JP JP2007505632A patent/JP2007530652A/ja active Pending
- 2005-03-30 CA CA002561400A patent/CA2561400A1/en not_active Abandoned
- 2005-03-30 BR BRPI0509382-1A patent/BRPI0509382A/pt not_active IP Right Cessation
- 2005-03-31 TW TW094110351A patent/TW200536814A/zh unknown
- 2005-03-31 PE PE2005000372A patent/PE20060678A1/es not_active Application Discontinuation
- 2005-03-31 AR ARP050101278A patent/AR052301A1/es not_active Application Discontinuation
-
2006
- 2006-09-13 IL IL178064A patent/IL178064A0/en unknown
- 2006-10-26 NO NO20064884A patent/NO20064884L/no not_active Application Discontinuation
- 2006-10-30 MA MA29421A patent/MA28558B1/fr unknown
Also Published As
Publication number | Publication date |
---|---|
WO2005095328A1 (en) | 2005-10-13 |
EP1730104A1 (en) | 2006-12-13 |
KR20070000508A (ko) | 2007-01-02 |
AU2005227733A1 (en) | 2005-10-13 |
BRPI0509382A (pt) | 2007-09-18 |
US20100063157A1 (en) | 2010-03-11 |
CA2561400A1 (en) | 2005-10-13 |
NO20064884L (no) | 2006-10-26 |
TW200536814A (en) | 2005-11-16 |
IL178064A0 (en) | 2006-12-31 |
US7846973B2 (en) | 2010-12-07 |
JP2007530652A (ja) | 2007-11-01 |
PE20060678A1 (es) | 2006-08-02 |
MA28558B1 (fr) | 2007-04-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |