AR048950A1 - Granulado soluble de bromhexina / hidrocloruro de bromhexina, procedimiento para su produccion y su utilizacion - Google Patents

Granulado soluble de bromhexina / hidrocloruro de bromhexina, procedimiento para su produccion y su utilizacion

Info

Publication number
AR048950A1
AR048950A1 ARP050101905A ARP050101905A AR048950A1 AR 048950 A1 AR048950 A1 AR 048950A1 AR P050101905 A ARP050101905 A AR P050101905A AR P050101905 A ARP050101905 A AR P050101905A AR 048950 A1 AR048950 A1 AR 048950A1
Authority
AR
Argentina
Prior art keywords
bromhexine
soluble
water
granulate
hydrochloride
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Suspension/Interruption
Application number
ARP050101905A
Other languages
English (en)
Inventor
Martin A Folger
Stefan Henke
Jens Schmalz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Vetmedica GmbH
Boehringer Ingelheim Vetmedica de C V SA
Original Assignee
Boehringer Ingelheim Vetmedica GmbH
Boehringer Ingelheim Vetmedica de C V SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to DE102004023930A priority Critical patent/DE102004023930A1/de
Application filed by Boehringer Ingelheim Vetmedica GmbH, Boehringer Ingelheim Vetmedica de C V SA filed Critical Boehringer Ingelheim Vetmedica GmbH
Publication of AR048950A1 publication Critical patent/AR048950A1/es
Suspension/Interruption legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/194Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • A61K9/2018Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2027Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Abstract

Granulado rápidamente soluble, obtenible por (a) produccion de un líquido acuoso para granular, contiene por lo menos un agente aglutinante, y (b) aplicacion por atomizacion del liquido para granular obtenido en la etapa (a) en una capa fluidizada, por un procedimiento en contracorriente, a una temperatura constante del aire entrante, sobre un vehículo, que contiene por lo menos un hidrato de carbono, empleándose bromhexina/hidrocloruro de bromhexina y acído cítrico, independientemente uno de otro, en el líquido para granular y/o en el vehículo. Por primera vez se pone a disposicion, mediante la ensenanza conforme al invento, un granulado soluble en agua, que contiene bromhexina / hidrocloruro de bromhexina como sustancia activa Este granulado conforme al invento, a pesar de la bromhexina o del hidrocloruro de bromhexina, que de por sí es escasamente soluble en agua, es soluble en agua, es decir que el grabulado se disuelve totalmente en el agua del medio en el transcurso de unos pocos minutos y pone en libertad la sustancia activa en su extension total.
ARP050101905A 2004-05-12 2005-05-11 Granulado soluble de bromhexina / hidrocloruro de bromhexina, procedimiento para su produccion y su utilizacion Suspension/Interruption AR048950A1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE102004023930A DE102004023930A1 (de) 2004-05-12 2004-05-12 Schnell lösliches Granulat von Bromhexin/Bromhexinhydrochlorid, Verfahren zu dessen Herstellung und dessen Verwendung

Publications (1)

Publication Number Publication Date
AR048950A1 true AR048950A1 (es) 2006-06-14

Family

ID=34980024

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050101905A Suspension/Interruption AR048950A1 (es) 2004-05-12 2005-05-11 Granulado soluble de bromhexina / hidrocloruro de bromhexina, procedimiento para su produccion y su utilizacion

Country Status (6)

Country Link
US (1) US20050266073A1 (es)
EP (1) EP1753401A1 (es)
AR (1) AR048950A1 (es)
DE (1) DE102004023930A1 (es)
TW (1) TW200607531A (es)
WO (1) WO2005110373A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102293741B (zh) * 2011-08-24 2013-02-20 石家庄东方药业有限公司 一种盐酸溴己新注射液及其制备方法和用途
CN104287970A (zh) * 2014-11-07 2015-01-21 四川旭华制药有限公司 一种胶囊制粒机

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3126703A1 (de) * 1981-07-07 1983-01-27 Thomae Gmbh Dr K Bromhexin-retardform und verfahren zu ihrer herstellung
DE69331378D1 (de) * 1992-02-18 2002-01-31 Nippon Shinyaku Co Ltd Verfahren zur Herstellung von schnelllöslicher Tabletten und schnelllöslichen Tablette beinhaltend Xylitol
EP1121940A1 (en) * 2000-01-31 2001-08-08 New Pharma Research Sweden AB Pharmaceutical compositions comprising an antibiotic and bromhexine, and process for their preparation
US7799342B2 (en) * 2000-12-06 2010-09-21 Wyeth Llc Fast dissolving tablet

Also Published As

Publication number Publication date
TW200607531A (en) 2006-03-01
DE102004023930A1 (de) 2005-12-08
WO2005110373A1 (de) 2005-11-24
US20050266073A1 (en) 2005-12-01
EP1753401A1 (de) 2007-02-21

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