AR048950A1 - Granulado soluble de bromhexina / hidrocloruro de bromhexina, procedimiento para su produccion y su utilizacion - Google Patents
Granulado soluble de bromhexina / hidrocloruro de bromhexina, procedimiento para su produccion y su utilizacionInfo
- Publication number
- AR048950A1 AR048950A1 ARP050101905A ARP050101905A AR048950A1 AR 048950 A1 AR048950 A1 AR 048950A1 AR P050101905 A ARP050101905 A AR P050101905A AR P050101905 A ARP050101905 A AR P050101905A AR 048950 A1 AR048950 A1 AR 048950A1
- Authority
- AR
- Argentina
- Prior art keywords
- bromhexine
- soluble
- water
- granulate
- hydrochloride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Suspension/Interruption
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
Abstract
Granulado rápidamente soluble, obtenible por (a) produccion de un líquido acuoso para granular, contiene por lo menos un agente aglutinante, y (b) aplicacion por atomizacion del liquido para granular obtenido en la etapa (a) en una capa fluidizada, por un procedimiento en contracorriente, a una temperatura constante del aire entrante, sobre un vehículo, que contiene por lo menos un hidrato de carbono, empleándose bromhexina/hidrocloruro de bromhexina y acído cítrico, independientemente uno de otro, en el líquido para granular y/o en el vehículo. Por primera vez se pone a disposicion, mediante la ensenanza conforme al invento, un granulado soluble en agua, que contiene bromhexina / hidrocloruro de bromhexina como sustancia activa Este granulado conforme al invento, a pesar de la bromhexina o del hidrocloruro de bromhexina, que de por sí es escasamente soluble en agua, es soluble en agua, es decir que el grabulado se disuelve totalmente en el agua del medio en el transcurso de unos pocos minutos y pone en libertad la sustancia activa en su extension total.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102004023930A DE102004023930A1 (de) | 2004-05-12 | 2004-05-12 | Schnell lösliches Granulat von Bromhexin/Bromhexinhydrochlorid, Verfahren zu dessen Herstellung und dessen Verwendung |
Publications (1)
Publication Number | Publication Date |
---|---|
AR048950A1 true AR048950A1 (es) | 2006-06-14 |
Family
ID=34980024
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP050101905A Suspension/Interruption AR048950A1 (es) | 2004-05-12 | 2005-05-11 | Granulado soluble de bromhexina / hidrocloruro de bromhexina, procedimiento para su produccion y su utilizacion |
Country Status (6)
Country | Link |
---|---|
US (1) | US20050266073A1 (es) |
EP (1) | EP1753401A1 (es) |
AR (1) | AR048950A1 (es) |
DE (1) | DE102004023930A1 (es) |
TW (1) | TW200607531A (es) |
WO (1) | WO2005110373A1 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102293741B (zh) * | 2011-08-24 | 2013-02-20 | 石家庄东方药业有限公司 | 一种盐酸溴己新注射液及其制备方法和用途 |
CN104287970A (zh) * | 2014-11-07 | 2015-01-21 | 四川旭华制药有限公司 | 一种胶囊制粒机 |
CN112618493B (zh) * | 2021-01-22 | 2022-07-15 | 青岛农业大学 | 一种兽用盐酸溴己新可溶性粉、制备方法及应用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3126703A1 (de) * | 1981-07-07 | 1983-01-27 | Dr. Karl Thomae Gmbh, 7950 Biberach | Bromhexin-retardform und verfahren zu ihrer herstellung |
DE627218T1 (de) * | 1992-02-18 | 1995-08-24 | Nippon Shinyaku Co Ltd | Schnelllösliche tablette. |
EP1121940A1 (en) * | 2000-01-31 | 2001-08-08 | New Pharma Research Sweden AB | Pharmaceutical compositions comprising an antibiotic and bromhexine, and process for their preparation |
US7799342B2 (en) * | 2000-12-06 | 2010-09-21 | Wyeth Llc | Fast dissolving tablet |
-
2004
- 2004-05-12 DE DE102004023930A patent/DE102004023930A1/de not_active Withdrawn
-
2005
- 2005-05-04 WO PCT/EP2005/004822 patent/WO2005110373A1/de not_active Application Discontinuation
- 2005-05-04 EP EP05737936A patent/EP1753401A1/de not_active Withdrawn
- 2005-05-11 AR ARP050101905A patent/AR048950A1/es not_active Suspension/Interruption
- 2005-05-11 TW TW094115294A patent/TW200607531A/zh unknown
- 2005-05-12 US US11/127,971 patent/US20050266073A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20050266073A1 (en) | 2005-12-01 |
WO2005110373A1 (de) | 2005-11-24 |
TW200607531A (en) | 2006-03-01 |
EP1753401A1 (de) | 2007-02-21 |
DE102004023930A1 (de) | 2005-12-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FB | Suspension of granting procedure |