AR046674A1 - Derivados de fenoxiacetamida y su uso para la preparacion de difenilaminas - Google Patents
Derivados de fenoxiacetamida y su uso para la preparacion de difenilaminasInfo
- Publication number
- AR046674A1 AR046674A1 ARP040104382A ARP040104382A AR046674A1 AR 046674 A1 AR046674 A1 AR 046674A1 AR P040104382 A ARP040104382 A AR P040104382A AR P040104382 A ARP040104382 A AR P040104382A AR 046674 A1 AR046674 A1 AR 046674A1
- Authority
- AR
- Argentina
- Prior art keywords
- alk
- hal
- preparation
- het
- nhalk
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/18—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides
- C07C235/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
Abstract
Procedimiento para su preparación y a su uso para la preparación de difenilaminas. Reivindicación 1: Compuestos de la fórmula general (1), en donde: R1, que pueden ser idénticos o diferentes, se seleccionan, de manera independiente, de -Hal, -O- Alk, -N(Alk)2, -NH-C(=O)-Alk, -O-C-hal3, -NO2, -NH2, -NHAlk, -C(=O)Hal, -C(=O)OAlk, -OH, -C(=O)-NH2, -C(=O)-NHAlk, -C(=O)-N(Alk)2, -NH-(C=O)-OAlk; -H, -CN, -AlK, -C(=O)Alk, -NAlk-C(O)-O-Alk y -NAlk2; n1 = número entero entre 1 y 5; R2, que pueden ser idénticos o diferentes, se seleccionan, de manera independiente, de -X-(C=O)-Y-(A)n y -CN; n2 = número entero entre 1 y 5; n = 0 cuando Y = Hal; n = 1 cuando Y = o n = 2 cuando Y = N; X = enlace o -Alk-; Y = -O-, -N- o Hal; A = -H, -Alk, -Alk- Ar, -Alk-Het, -Ar o -Het, estando Ar y Het opcionalmente sustituidos con Het o Hal; R3 = -H, -Alk, -NAlk2, -NHAlk o -NH2 a excepción de los compuestos para los cuales: R2 = -CN en la posición 4 (4-CN), n2 = 1, R3 = H, n1 = 2 y R1 = (2-NHMe, 5-NO2); o R3 = Me, n1 = 1 y R1 = -NH-(C=O)-O-Me; R2 = 4-(-COOH), n2 = 1, y R3 = (CH2)15-Me, n1 = 4 y R1 = (2-OH,3,5-diCl,4-Et), -R3 = H, n1 = 4 y R1 = (2-OH,3,5,-diCl,4-Me); R2 = 4-(-COOMe), n2 = 1, n1 = 1 y R3 = H, R1 = 2-(-C(=O)-CH3) y también sus sales por adición.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0313952A FR2862965B1 (fr) | 2003-11-27 | 2003-11-27 | Nouveaux derives de phenoxyacetamides et leur utilisation pour la preparation de diphenylamides. |
Publications (1)
Publication Number | Publication Date |
---|---|
AR046674A1 true AR046674A1 (es) | 2005-12-14 |
Family
ID=34566200
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP040104382A AR046674A1 (es) | 2003-11-27 | 2004-11-26 | Derivados de fenoxiacetamida y su uso para la preparacion de difenilaminas |
Country Status (7)
Country | Link |
---|---|
US (1) | US20070072915A1 (es) |
EP (1) | EP1687256A1 (es) |
AR (1) | AR046674A1 (es) |
AU (1) | AU2004293159A1 (es) |
CA (1) | CA2547281A1 (es) |
FR (1) | FR2862965B1 (es) |
WO (1) | WO2005051892A1 (es) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2926297B1 (fr) | 2008-01-10 | 2013-03-08 | Centre Nat Rech Scient | Molecules chimiques inhibitrices du mecanisme d'epissage pour traiter des maladies resultant d'anomalies d'epissage. |
GB0813403D0 (en) | 2008-07-22 | 2008-08-27 | Lectus Therapeutics Ltd | Potassium ion channel modulators & uses thereof |
US9079880B2 (en) | 2010-07-07 | 2015-07-14 | Boehringer Ingelheim International Gmbh | Rho kinase inhibitors |
US8697911B2 (en) | 2010-07-07 | 2014-04-15 | Boehringer Ingelheim International Gmbh | Rho kinase inhibitors |
EP2630144B1 (en) | 2010-10-19 | 2016-09-07 | Boehringer Ingelheim International GmbH | Rho kinase inhibitors |
EP2505198A1 (en) | 2011-04-01 | 2012-10-03 | Société Splicos | Compounds for use as therapeutic agents affecting p53 expression and/or activity |
CN104119266A (zh) * | 2013-04-25 | 2014-10-29 | 浙江大学 | 从酚类化合物出发制备咔唑的方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5475139A (en) * | 1993-10-22 | 1995-12-12 | Yung Shin Pharm. Ind. Co., Ltd. | Method for the preparation of substituted derivatives of diphenyl amine |
AU2003221178B2 (en) * | 2002-03-28 | 2006-06-15 | Tanabe Seiyaku Co., Ltd. | Benzofuran derivative |
-
2003
- 2003-11-27 FR FR0313952A patent/FR2862965B1/fr not_active Expired - Fee Related
-
2004
- 2004-11-05 US US10/580,546 patent/US20070072915A1/en not_active Abandoned
- 2004-11-05 AU AU2004293159A patent/AU2004293159A1/en not_active Abandoned
- 2004-11-05 CA CA002547281A patent/CA2547281A1/en not_active Abandoned
- 2004-11-05 EP EP04797651A patent/EP1687256A1/en not_active Withdrawn
- 2004-11-05 WO PCT/EP2004/012541 patent/WO2005051892A1/en active Application Filing
- 2004-11-26 AR ARP040104382A patent/AR046674A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
EP1687256A1 (en) | 2006-08-09 |
FR2862965B1 (fr) | 2007-09-07 |
AU2004293159A1 (en) | 2005-06-09 |
FR2862965A1 (fr) | 2005-06-03 |
WO2005051892A1 (en) | 2005-06-09 |
CA2547281A1 (en) | 2005-06-09 |
US20070072915A1 (en) | 2007-03-29 |
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Legal Events
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FB | Suspension of granting procedure |