AR046674A1 - Derivados de fenoxiacetamida y su uso para la preparacion de difenilaminas - Google Patents

Derivados de fenoxiacetamida y su uso para la preparacion de difenilaminas

Info

Publication number
AR046674A1
AR046674A1 ARP040104382A ARP040104382A AR046674A1 AR 046674 A1 AR046674 A1 AR 046674A1 AR P040104382 A ARP040104382 A AR P040104382A AR P040104382 A ARP040104382 A AR P040104382A AR 046674 A1 AR046674 A1 AR 046674A1
Authority
AR
Argentina
Prior art keywords
alk
hal
preparation
het
nhalk
Prior art date
Application number
ARP040104382A
Other languages
English (en)
Inventor
Claude Lardy
Bernard Boudet
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of AR046674A1 publication Critical patent/AR046674A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/18—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides
    • C07C235/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the singly-bound oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. phenoxyacetamides having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/58—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)

Abstract

Procedimiento para su preparación y a su uso para la preparación de difenilaminas. Reivindicación 1: Compuestos de la fórmula general (1), en donde: R1, que pueden ser idénticos o diferentes, se seleccionan, de manera independiente, de -Hal, -O- Alk, -N(Alk)2, -NH-C(=O)-Alk, -O-C-hal3, -NO2, -NH2, -NHAlk, -C(=O)Hal, -C(=O)OAlk, -OH, -C(=O)-NH2, -C(=O)-NHAlk, -C(=O)-N(Alk)2, -NH-(C=O)-OAlk; -H, -CN, -AlK, -C(=O)Alk, -NAlk-C(O)-O-Alk y -NAlk2; n1 = número entero entre 1 y 5; R2, que pueden ser idénticos o diferentes, se seleccionan, de manera independiente, de -X-(C=O)-Y-(A)n y -CN; n2 = número entero entre 1 y 5; n = 0 cuando Y = Hal; n = 1 cuando Y = o n = 2 cuando Y = N; X = enlace o -Alk-; Y = -O-, -N- o Hal; A = -H, -Alk, -Alk- Ar, -Alk-Het, -Ar o -Het, estando Ar y Het opcionalmente sustituidos con Het o Hal; R3 = -H, -Alk, -NAlk2, -NHAlk o -NH2 a excepción de los compuestos para los cuales: R2 = -CN en la posición 4 (4-CN), n2 = 1, R3 = H, n1 = 2 y R1 = (2-NHMe, 5-NO2); o R3 = Me, n1 = 1 y R1 = -NH-(C=O)-O-Me; R2 = 4-(-COOH), n2 = 1, y R3 = (CH2)15-Me, n1 = 4 y R1 = (2-OH,3,5-diCl,4-Et), -R3 = H, n1 = 4 y R1 = (2-OH,3,5,-diCl,4-Me); R2 = 4-(-COOMe), n2 = 1, n1 = 1 y R3 = H, R1 = 2-(-C(=O)-CH3) y también sus sales por adición.
ARP040104382A 2003-11-27 2004-11-26 Derivados de fenoxiacetamida y su uso para la preparacion de difenilaminas AR046674A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0313952A FR2862965B1 (fr) 2003-11-27 2003-11-27 Nouveaux derives de phenoxyacetamides et leur utilisation pour la preparation de diphenylamides.

Publications (1)

Publication Number Publication Date
AR046674A1 true AR046674A1 (es) 2005-12-14

Family

ID=34566200

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP040104382A AR046674A1 (es) 2003-11-27 2004-11-26 Derivados de fenoxiacetamida y su uso para la preparacion de difenilaminas

Country Status (7)

Country Link
US (1) US20070072915A1 (es)
EP (1) EP1687256A1 (es)
AR (1) AR046674A1 (es)
AU (1) AU2004293159A1 (es)
CA (1) CA2547281A1 (es)
FR (1) FR2862965B1 (es)
WO (1) WO2005051892A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2926297B1 (fr) 2008-01-10 2013-03-08 Centre Nat Rech Scient Molecules chimiques inhibitrices du mecanisme d'epissage pour traiter des maladies resultant d'anomalies d'epissage.
GB0813403D0 (en) 2008-07-22 2008-08-27 Lectus Therapeutics Ltd Potassium ion channel modulators & uses thereof
US9079880B2 (en) 2010-07-07 2015-07-14 Boehringer Ingelheim International Gmbh Rho kinase inhibitors
US8697911B2 (en) 2010-07-07 2014-04-15 Boehringer Ingelheim International Gmbh Rho kinase inhibitors
EP2630144B1 (en) 2010-10-19 2016-09-07 Boehringer Ingelheim International GmbH Rho kinase inhibitors
EP2505198A1 (en) 2011-04-01 2012-10-03 Société Splicos Compounds for use as therapeutic agents affecting p53 expression and/or activity
CN104119266A (zh) * 2013-04-25 2014-10-29 浙江大学 从酚类化合物出发制备咔唑的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5475139A (en) * 1993-10-22 1995-12-12 Yung Shin Pharm. Ind. Co., Ltd. Method for the preparation of substituted derivatives of diphenyl amine
AU2003221178B2 (en) * 2002-03-28 2006-06-15 Tanabe Seiyaku Co., Ltd. Benzofuran derivative

Also Published As

Publication number Publication date
EP1687256A1 (en) 2006-08-09
FR2862965B1 (fr) 2007-09-07
AU2004293159A1 (en) 2005-06-09
FR2862965A1 (fr) 2005-06-03
WO2005051892A1 (en) 2005-06-09
CA2547281A1 (en) 2005-06-09
US20070072915A1 (en) 2007-03-29

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