AR040819A1 - Transdermal delivery device having coated vaccine microprojections - Google Patents

Transdermal delivery device having coated vaccine microprojections

Info

Publication number
AR040819A1
AR040819A1 AR20030102844A ARP030102844A AR040819A1 AR 040819 A1 AR040819 A1 AR 040819A1 AR 20030102844 A AR20030102844 A AR 20030102844A AR P030102844 A ARP030102844 A AR P030102844A AR 040819 A1 AR040819 A1 AR 040819A1
Authority
AR
Argentina
Prior art keywords
transdermal delivery
skin
microprojections
delivery device
applied
Prior art date
Application number
AR20030102844A
Other languages
Spanish (es)
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US40226902P priority Critical
Application filed by Alza Corp filed Critical Alza Corp
Publication of AR040819A1 publication Critical patent/AR040819A1/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/20Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205Vaccinating by means of needles or other puncturing devices
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/145Orthomyxoviridae, e.g. influenza virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/186Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0021Intradermal administration, e.g. through microneedle arrays, needleless injectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/54Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA Viruses negative-sense
    • C12N2760/00011MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA Viruses negative-sense ssRNA Viruses negative-sense
    • C12N2760/16011Orthomyxoviridae
    • C12N2760/16111Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Abstract

Se proporciona un dispositivo y método para administración transdérmica percutánea de un agente inmunológicamente activo. a device and method for percutaneous transdermal delivery of an immunologically active agent is provided. El agente es mezclado con surfactantes apropiados y disuelto en agua para formar una solución acuosa de revestimiento que tiene la concentración apropiada para revestir elementos de perforación de piel sumamente diminutos. The agent is mixed with suitable surfactants and dissolved in water to form an aqueous coating solution having the appropriate concentration for coating piercing elements extremely minute skin. La solución de revestimiento es aplicable a los elementos de perforación de piel utilizando técnicas de revestimientos conocidos y después es secada. The coating solution is applied to the skin piercing elements using techniques known coatings and then dried. El dispositivo es aplicado a la piel de un animal vivo, haciendo que las micros proyecciones perforan el estrato córneo y administren una dosis inmunológicamente eficaz del agente inmunológicamente activo al animal. The device is applied to the skin of a living animal, making the projections micros pierce the stratum corneum and administering an immunologically effective immunologically active agent to the animal dose.
AR20030102844A 2002-08-08 2003-08-07 Transdermal delivery device having coated vaccine microprojections AR040819A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US40226902P true 2002-08-08 2002-08-08

Publications (1)

Publication Number Publication Date
AR040819A1 true AR040819A1 (en) 2005-04-20

Family

ID=33489222

Family Applications (1)

Application Number Title Priority Date Filing Date
AR20030102844A AR040819A1 (en) 2002-08-08 2003-08-07 Transdermal delivery device having coated vaccine microprojections

Country Status (12)

Country Link
US (1) US20040096455A1 (en)
EP (1) EP1575570A2 (en)
JP (1) JP2006516205A (en)
KR (1) KR20050063762A (en)
CN (1) CN1691938A (en)
AR (1) AR040819A1 (en)
AU (2) AU2003304153A1 (en)
BR (1) BR0313474A (en)
CA (1) CA2495270A1 (en)
MX (1) MXPA05001912A (en)
TW (1) TW200409657A (en)
WO (1) WO2004105729A2 (en)

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US20020193729A1 (en) * 2001-04-20 2002-12-19 Cormier Michel J.N. Microprojection array immunization patch and method
US7244703B2 (en) * 2001-06-22 2007-07-17 Bentley Pharmaceuticals, Inc. Pharmaceutical compositions and methods for peptide treatment
US7828827B2 (en) 2002-05-24 2010-11-09 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
US20040087992A1 (en) * 2002-08-09 2004-05-06 Vladimir Gartstein Microstructures for delivering a composition cutaneously to skin using rotatable structures
US7578954B2 (en) * 2003-02-24 2009-08-25 Corium International, Inc. Method for manufacturing microstructures having multiple microelements with through-holes
KR20060037320A (en) * 2003-07-02 2006-05-03 알자 코포레이션 Microprojection array immunization patch and method
US8961477B2 (en) * 2003-08-25 2015-02-24 3M Innovative Properties Company Delivery of immune response modifier compounds
CA2560840C (en) * 2004-03-24 2014-05-06 Corium International, Inc. Transdermal delivery device
CN101120101A (en) * 2004-04-13 2008-02-06 阿尔扎公司 Apparatus and method for transdermal delivery of multiple vaccines
JP2008514644A (en) * 2004-09-28 2008-05-08 アルザ コーポレイション Stabilization of alum adjuvant immune active agent
US8900180B2 (en) * 2005-11-18 2014-12-02 3M Innovative Properties Company Coatable compositions, coatings derived therefrom and microarrays having such coatings
TW200700094A (en) * 2005-01-31 2007-01-01 Alza Corp Coated microprojections having reduced variability and method for producing same
US20060204562A1 (en) * 2005-02-16 2006-09-14 Cormier Michel J Microprojection arrays with improved biocompatibility
US20070078414A1 (en) * 2005-08-05 2007-04-05 Mcallister Devin V Methods and devices for delivering agents across biological barriers
US20080020023A1 (en) * 2006-07-20 2008-01-24 Shiping Wang Nonaqueous coating composition for elastomeric articles and articles containing the same
EP2121111B1 (en) * 2007-01-22 2018-03-14 Corium International, Inc. Applicators for microneedle arrays
CA2686093C (en) * 2007-04-16 2018-05-08 Corium International, Inc. Solvent-cast microneedle arrays containing active
JP2008284318A (en) * 2007-05-15 2008-11-27 Kosumedei Seiyaku Kk Microneedle for dosing, including living body origin matter
WO2009048607A1 (en) 2007-10-10 2009-04-16 Corium International, Inc. Vaccine delivery via microneedle arrays
JP5178132B2 (en) * 2007-10-11 2013-04-10 キヤノン株式会社 The image processing system and image processing method
KR101578420B1 (en) * 2008-06-30 2015-12-17 히사미쓰 세이야꾸 가부시키가이샤 Microneedle device, and method for enhancing the efficacy of influenza vaccine by using microneedle device
KR101634836B1 (en) * 2008-12-26 2016-06-29 히사미쓰 세이야꾸 가부시키가이샤 Microneedle device
WO2010124255A2 (en) * 2009-04-24 2010-10-28 Corium International, Inc. Methods for manufacturing microprojection arrays
EP2566501B1 (en) 2010-05-04 2019-03-13 Corium International, Inc. Method and device for transdermal delivery of parathyroid hormone using a microprojection array
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US9517205B2 (en) 2010-08-20 2016-12-13 Seqirus UK Limited Soluble needle arrays for delivery of influenza vaccines
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CN103796683A (en) 2011-04-21 2014-05-14 塔夫茨大学信托人 Compositions and methods for stabilization of active agents
GB201116143D0 (en) * 2011-09-16 2011-11-02 Univ Greenwich Method of coating microneedle devices
WO2013038137A1 (en) * 2011-09-16 2013-03-21 University Of Greenwich Method of coating microneedle devices
AU2014249471B2 (en) 2013-03-12 2019-01-24 Corium International, Inc. Microprojection applicators
CA2903583A1 (en) 2013-03-15 2014-09-18 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
CA2903763A1 (en) * 2013-03-15 2014-09-25 Corium International, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
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WO2018053524A1 (en) 2016-09-19 2018-03-22 Vaxess Technologies, Inc. Vaccine formulations with increased stability

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Also Published As

Publication number Publication date
BR0313474A (en) 2007-07-31
EP1575570A2 (en) 2005-09-21
JP2006516205A (en) 2006-06-29
MXPA05001912A (en) 2005-08-29
AU2003304153A1 (en) 2005-01-21
WO2004105729A3 (en) 2005-07-14
TW200409657A (en) 2004-06-16
AU2010200087A1 (en) 2010-01-28
KR20050063762A (en) 2005-06-28
CA2495270A1 (en) 2004-12-09
US20040096455A1 (en) 2004-05-20
CN1691938A (en) 2005-11-02
WO2004105729A2 (en) 2004-12-09

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Legal Events

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