AR035071A1 - Compuestos para el tratamiento de la disfuncion endotelial; metodo para producir a dichos compuestos farmaceuticos; uso de dichos compuestos para la manufactura de un medicamento - Google Patents
Compuestos para el tratamiento de la disfuncion endotelial; metodo para producir a dichos compuestos farmaceuticos; uso de dichos compuestos para la manufactura de un medicamentoInfo
- Publication number
- AR035071A1 AR035071A1 ARP010105032A ARP010105032A AR035071A1 AR 035071 A1 AR035071 A1 AR 035071A1 AR P010105032 A ARP010105032 A AR P010105032A AR P010105032 A ARP010105032 A AR P010105032A AR 035071 A1 AR035071 A1 AR 035071A1
- Authority
- AR
- Argentina
- Prior art keywords
- compounds
- radical
- group
- treatment
- dysfunction
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
El compuesto comprende un activador del receptor activado de multiplicador de peroxisoma (PPAR) y una benzoquinona de fórmula (1) en la cual R1, R2 y R3 independientemente están formados por: un grupo alquilo C1-8, o un grupo alcoxi C1-8; R4 consiste en: un átomo de hidrógeno, un grupo hidrocarbilo C1-60, un radical OR5, un radical SR6, un radical N(R7) (R8); un grupo nitro, o un grupo carboxilo; R5, R6, R7 y R8 están formados por: un átomo de hidrógeno, o un grupo alquilo que contiene C1-20, O un precursor de los anteriores capaz de metabolizarse en un organismo humano o animal en dicha benzoquinona, o una sal farmacéuticamente aceptable de los anteriores. El activador PPAR es elegido entre un fibrato o tiazolidinediona. El uso de estos compuestos es útil como agente para el tratamiento y/o prevención de desórdenes por disfunción endotelial , tal como enfermedad cardiovascular, accidentes cerebro vascular e infarto miocardio.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPR1038A AUPR103800A0 (en) | 2000-10-26 | 2000-10-26 | Compositions for the treatment of endothelial dysfunction |
| AUPR3424A AUPR342401A0 (en) | 2001-02-28 | 2001-02-28 | Compositions for the treatment of endothelial dysfunction |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR035071A1 true AR035071A1 (es) | 2004-04-14 |
Family
ID=25646491
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010105032A AR035071A1 (es) | 2000-10-26 | 2001-10-26 | Compuestos para el tratamiento de la disfuncion endotelial; metodo para producir a dichos compuestos farmaceuticos; uso de dichos compuestos para la manufactura de un medicamento |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US7410983B2 (es) |
| EP (1) | EP1328266B1 (es) |
| JP (1) | JP4236464B2 (es) |
| KR (1) | KR100862129B1 (es) |
| CN (1) | CN1220488C (es) |
| AR (1) | AR035071A1 (es) |
| AT (1) | ATE316787T1 (es) |
| AU (1) | AU2176502A (es) |
| BG (1) | BG65979B1 (es) |
| BR (1) | BR0114701A (es) |
| CA (1) | CA2426625C (es) |
| CY (1) | CY1105007T1 (es) |
| CZ (1) | CZ301282B6 (es) |
| DE (1) | DE60117046T2 (es) |
| DK (1) | DK1328266T3 (es) |
| DZ (1) | DZ3442A1 (es) |
| EE (1) | EE05281B1 (es) |
| ES (1) | ES2257457T3 (es) |
| HK (1) | HK1057340A1 (es) |
| HU (1) | HUP0303566A3 (es) |
| IL (2) | IL155524A0 (es) |
| MA (1) | MA25847A1 (es) |
| MX (1) | MXPA03003733A (es) |
| NO (1) | NO332260B1 (es) |
| PL (1) | PL212952B1 (es) |
| PT (1) | PT1328266E (es) |
| RU (1) | RU2003111175A (es) |
| SK (1) | SK287992B6 (es) |
| TN (1) | TNSN01151A1 (es) |
| WO (1) | WO2002034259A1 (es) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60219793T2 (de) | 2001-07-11 | 2008-01-24 | Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield | Verfahren zur Behandlung von Cytokin-Vermittelten Erkrankungen |
| WO2003075911A1 (en) * | 2002-03-11 | 2003-09-18 | Peter Zahradka | Use of ppar alpha agonists for the treatment of vascular and renal diseases |
| US20070225614A1 (en) | 2004-05-26 | 2007-09-27 | Endothelix, Inc. | Method and apparatus for determining vascular health conditions |
| FR2845602B1 (fr) * | 2002-10-11 | 2005-07-08 | Servier Lab | Association entre un ligand des recepteurs actives par les proliferateurs de peroxisomes et un agent antioxydant et les compositions pharmaceutiques qui les contiennent |
| GB0309154D0 (en) * | 2003-01-14 | 2003-05-28 | Aventis Pharma Inc | Use of insulin glargine to reduce or prevent cardiovascular events in patients being treated for dysglycemia |
| JP2005104951A (ja) * | 2003-01-17 | 2005-04-21 | Kirin Brewery Co Ltd | 血圧降下用組成物および血管柔軟性改善用組成物並びにこれらの機能が付与された食品 |
| FR2868313B1 (fr) * | 2004-03-31 | 2008-08-15 | Servier Lab | Nouvelle association entre un compose heterocyclique et un agent antioxydant et les compositions pharmaceutiques qui les contiennent |
| EP1621200A1 (en) * | 2004-07-26 | 2006-02-01 | Fournier Laboratories Ireland Limited | Pharmaceutical combinations containing an inhibitor of platelet aggregation and a fibrate |
| MX359292B (es) | 2005-06-01 | 2018-09-24 | Bioelectron Tech Corp | Sustancias terapeuticas activas redox para el tratamiento de enfermedades mitocondriales y otras condiciones y modulacion de biomarcadores de energia. |
| EP1785133A1 (en) * | 2005-11-10 | 2007-05-16 | Laboratoires Fournier S.A. | Use of fenofibrate or a derivative thereof for preventing diabetic retinopathy |
| CA2635280C (en) | 2006-02-22 | 2017-12-12 | Edison Pharmaceuticals, Inc. | Side chain variants of redox-active therapeutics for treatment of mitochondrial diseases and other conditions and modulation of energy biomarkers |
| WO2007106912A2 (en) * | 2006-03-16 | 2007-09-20 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Peroxisome-proliferator activated receptor-alpha agonists for organ preservation |
| US20070225606A1 (en) * | 2006-03-22 | 2007-09-27 | Endothelix, Inc. | Method and apparatus for comprehensive assessment of vascular health |
| US20080027330A1 (en) * | 2006-05-15 | 2008-01-31 | Endothelix, Inc. | Risk assessment method for acute cardiovascular events |
| US20080081963A1 (en) * | 2006-09-29 | 2008-04-03 | Endothelix, Inc. | Methods and Apparatus for Profiling Cardiovascular Vulnerability to Mental Stress |
| KR100989093B1 (ko) | 2008-01-18 | 2010-10-25 | 한화제약주식회사 | 생강나무 가지의 추출물을 포함하는 심혈관계 질환의 예방 및 치료용 조성물 |
| LT3827815T (lt) | 2008-09-10 | 2023-10-10 | Ptc Therapeutics, Inc. | Psichologinių raidos sutrikimų gydymas oksidacijos redukcijos atžvilgiu aktyviais vaistais |
| EP2391219A4 (en) * | 2009-01-29 | 2013-03-06 | Joshua D Levine | METHOD FOR ADDING VEGETABLE SUBSTANCES / NUTRITIONAL AGGREGATES FOR PHARMACEUTICAL TREATMENT IN A PHARMACOTHERAPEUTIC TREATMENT |
| US8973851B2 (en) * | 2009-07-01 | 2015-03-10 | The Procter & Gamble Company | Apparatus and methods for producing charged fluid droplets |
| US8772349B2 (en) * | 2010-03-26 | 2014-07-08 | Vivacell Biotechnology Espana, S.L. | Cannabinoid quinone derivatives |
| RU2554500C2 (ru) * | 2013-09-20 | 2015-06-27 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) | Способ лечения ишемического инсульта |
| US10703701B2 (en) | 2015-12-17 | 2020-07-07 | Ptc Therapeutics, Inc. | Fluoroalkyl, fluoroalkoxy, phenoxy, heteroaryloxy, alkoxy, and amine 1,4-benzoquinone derivatives for treatment of oxidative stress disorders |
| WO2019084540A1 (en) | 2017-10-27 | 2019-05-02 | Zeta Biolongevity, Inc. | COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING PROTEINURY AND ENDOTHELIAL EROSION |
| CN110907407B (zh) * | 2019-12-03 | 2022-02-25 | 东北石油大学 | 一种基于spr的高灵敏度光子准晶体光纤折射率传感器 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5229385A (en) | 1986-01-30 | 1993-07-20 | Takeda Chemical Industries, Ltd. | Quinone derivatives, their production and use |
| FR2627696B1 (fr) | 1988-02-26 | 1991-09-13 | Fournier Innovation Synergie | Nouvelle forme galenique du fenofibrate |
| FI102273B (fi) | 1989-09-11 | 1998-11-13 | Eisai Co Ltd | Kinonijohdannaiset, niiden valmistaminen ja niiden farmakologinen käyt tö |
| FR2730231B1 (fr) * | 1995-02-02 | 1997-04-04 | Fournier Sca Lab | Association de fenofibrate et de vitamine e, utilisation en therapeutique |
| US6063407A (en) * | 1995-02-16 | 2000-05-16 | The General Hospital Corporation | Treatment of vascular thrombosis and restenosis with inhaled nitric oxide |
| AU1856997A (en) | 1996-02-02 | 1997-08-22 | Merck & Co., Inc. | Method for raising hdl cholesterol levels |
| GB9606805D0 (en) | 1996-03-30 | 1996-06-05 | Glaxo Wellcome Inc | Medicaments |
| HUP0400931A2 (hu) | 1997-11-28 | 2004-07-28 | Karsanov, Nyikolai Vaszilievics | Hypoxia és ischaemia elleni gyógyszer |
| US6423742B1 (en) * | 1999-09-02 | 2002-07-23 | Drake Larson | Compositions for reducing vascular plaque formation and methods of using same |
-
2001
- 2001-10-23 PL PL361635A patent/PL212952B1/pl not_active IP Right Cessation
- 2001-10-23 AT AT01988586T patent/ATE316787T1/de active
- 2001-10-23 EE EEP200300165A patent/EE05281B1/xx not_active IP Right Cessation
- 2001-10-23 DE DE60117046T patent/DE60117046T2/de not_active Expired - Lifetime
- 2001-10-23 HU HU0303566A patent/HUP0303566A3/hu unknown
- 2001-10-23 MX MXPA03003733A patent/MXPA03003733A/es active IP Right Grant
- 2001-10-23 BR BR0114701-3A patent/BR0114701A/pt not_active Application Discontinuation
- 2001-10-23 WO PCT/EP2001/012425 patent/WO2002034259A1/en active IP Right Grant
- 2001-10-23 US US10/399,639 patent/US7410983B2/en not_active Expired - Fee Related
- 2001-10-23 PT PT01988586T patent/PT1328266E/pt unknown
- 2001-10-23 CZ CZ20031148A patent/CZ301282B6/cs not_active IP Right Cessation
- 2001-10-23 KR KR1020037004793A patent/KR100862129B1/ko not_active IP Right Cessation
- 2001-10-23 CA CA2426625A patent/CA2426625C/en not_active Expired - Fee Related
- 2001-10-23 RU RU2003111175/15A patent/RU2003111175A/ru not_active Application Discontinuation
- 2001-10-23 CN CNB01817972XA patent/CN1220488C/zh not_active Expired - Fee Related
- 2001-10-23 DK DK01988586T patent/DK1328266T3/da active
- 2001-10-23 IL IL15552401A patent/IL155524A0/xx active IP Right Grant
- 2001-10-23 SK SK508-2003A patent/SK287992B6/sk unknown
- 2001-10-23 AU AU2176502A patent/AU2176502A/xx active Pending
- 2001-10-23 EP EP01988586A patent/EP1328266B1/en not_active Expired - Lifetime
- 2001-10-23 DZ DZ013442A patent/DZ3442A1/fr active
- 2001-10-23 ES ES01988586T patent/ES2257457T3/es not_active Expired - Lifetime
- 2001-10-23 JP JP2002537311A patent/JP4236464B2/ja not_active Expired - Fee Related
- 2001-10-25 TN TNTNSN01151A patent/TNSN01151A1/en unknown
- 2001-10-26 AR ARP010105032A patent/AR035071A1/es unknown
-
2003
- 2003-04-21 IL IL155524A patent/IL155524A/en not_active IP Right Cessation
- 2003-04-24 NO NO20031851A patent/NO332260B1/no not_active IP Right Cessation
- 2003-04-25 BG BG107765A patent/BG65979B1/bg unknown
- 2003-04-25 MA MA27124A patent/MA25847A1/fr unknown
-
2004
- 2004-01-14 HK HK04100253A patent/HK1057340A1/xx not_active IP Right Cessation
-
2006
- 2006-03-21 CY CY20061100400T patent/CY1105007T1/el unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |