AR033946A1 - A TRANSDERMAL THERAPEUTIC SYSTEM THAT INCLUDES MICRORESERVORIES AND A PROCEDURE FOR THE MANUFACTURE OF MICRORESERVARY SYSTEMS BASED ON POLYSYLOXANES AND AMBIFILLE SOLVENTS. - Google Patents

A TRANSDERMAL THERAPEUTIC SYSTEM THAT INCLUDES MICRORESERVORIES AND A PROCEDURE FOR THE MANUFACTURE OF MICRORESERVARY SYSTEMS BASED ON POLYSYLOXANES AND AMBIFILLE SOLVENTS.

Info

Publication number
AR033946A1
AR033946A1 ARP000103345A ARP000103345A AR033946A1 AR 033946 A1 AR033946 A1 AR 033946A1 AR P000103345 A ARP000103345 A AR P000103345A AR P000103345 A ARP000103345 A AR P000103345A AR 033946 A1 AR033946 A1 AR 033946A1
Authority
AR
Argentina
Prior art keywords
active substance
solvent
weight
manufacture
ambipyl
Prior art date
Application number
ARP000103345A
Other languages
Spanish (es)
Original Assignee
Lohmann Therapie Syst Lts
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lohmann Therapie Syst Lts filed Critical Lohmann Therapie Syst Lts
Publication of AR033946A1 publication Critical patent/AR033946A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7092—Transdermal patches having multiple drug layers or reservoirs, e.g. for obtaining a specific release pattern, or for combining different drugs

Abstract

Sistema terapéutico transdermal, que abarca una capa posterior no permeable para la sustancia activa, por lo menos una capa polimérica que contiene microreservorios, y por lo menos una sustancia activa, y una capa protectora a ser removida antes de la utilización, en donde: el polímero contenido en la capa polimérica consiste en polisiloxanos en por lo menos un 70% en peso, preferentemente en por lo menos un 80% en peso, los microreservorios contienen la sustancia activa en forma disuelta: el solvente para la sustancia activa contiene por lo menos un 50%, preferentemente por lo menos un 80%, en peso, de un solvente orgánico ambífilo, en especial dipolar: el solvente ambífilo no puede ser disuelto en más del 20% en peso en polisiloxano, siendo preferible que sea miscible con agua en una relación ponderal de por lo menos 1 parte de solvente: 3 partes de agua; procedimiento para la manufactura de sistemas de microreservorios que contienen una sustancia activa, donde la sustancia activa es disuelta en un solvente ambífilo que consiste en por lo menos un 50% en peso en solventes orgánicos dipolares, dicha solución es dispersada en una solución del polisiloxano, la dispersión resultante es aplicada a modo de revestimiento sobre un foil adecuado, y el solvente del polisiloxano es removido a temperaturas de entre 25 y 100°C, preferentemente de entre 30 y 80°C.Transdermal therapeutic system, which encompasses a non-permeable posterior layer for the active substance, at least one polymeric layer containing microreservoirs, and at least one active substance, and a protective layer to be removed before use, where: Polymer contained in the polymer layer consists of polysiloxanes in at least 70% by weight, preferably in at least 80% by weight, the micro-servants contain the active substance in dissolved form: the solvent for the active substance contains at least 50%, preferably at least 80%, by weight, of an ambipyl organic solvent, especially dipole: the ambipyl solvent cannot be dissolved in more than 20% by weight in polysiloxane, preferably it is miscible with water in a weight ratio of at least 1 part of solvent: 3 parts of water; process for the manufacture of micro-servo systems containing an active substance, where the active substance is dissolved in an ambipyl solvent consisting of at least 50% by weight in dipolar organic solvents, said solution is dispersed in a solution of the polysiloxane, The resulting dispersion is applied as a coating on a suitable foil, and the polysiloxane solvent is removed at temperatures between 25 and 100 ° C, preferably between 30 and 80 ° C.

ARP000103345A 1999-07-02 2000-06-30 A TRANSDERMAL THERAPEUTIC SYSTEM THAT INCLUDES MICRORESERVORIES AND A PROCEDURE FOR THE MANUFACTURE OF MICRORESERVARY SYSTEMS BASED ON POLYSYLOXANES AND AMBIFILLE SOLVENTS. AR033946A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19930340 1999-07-02
DE19958554A DE19958554C2 (en) 1999-07-02 1999-12-04 Microreservoir system based on polysiloxanes and ambiphilic solvents and their manufacture

Publications (1)

Publication Number Publication Date
AR033946A1 true AR033946A1 (en) 2004-01-21

Family

ID=7913294

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP000103345A AR033946A1 (en) 1999-07-02 2000-06-30 A TRANSDERMAL THERAPEUTIC SYSTEM THAT INCLUDES MICRORESERVORIES AND A PROCEDURE FOR THE MANUFACTURE OF MICRORESERVARY SYSTEMS BASED ON POLYSYLOXANES AND AMBIFILLE SOLVENTS.

Country Status (5)

Country Link
KR (1) KR100685553B1 (en)
AR (1) AR033946A1 (en)
DE (3) DE19958554C2 (en)
IL (1) IL147247A (en)
ZA (1) ZA200110455B (en)

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* Cited by examiner, † Cited by third party
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DE10141651B4 (en) * 2001-08-24 2007-02-15 Lts Lohmann Therapie-Systeme Ag Transdermal Therapeutic System (TTS) with the active ingredient Fentanyl and process for its preparation
US8246980B2 (en) * 2002-07-30 2012-08-21 Ucb Pharma Gmbh Transdermal delivery system
DE10234673B4 (en) 2002-07-30 2007-08-16 Schwarz Pharma Ag Hot-melt TTS for the administration of rotigotine and process for its preparation, and use of rotigotine in the manufacture of a hot-melt TTS
BRPI0318250B8 (en) * 2003-04-14 2021-05-25 Lts Lohmann Therapie Systeme Ag topical plaster with polysiloxane matrix and method for producing a topical plaster preparation
US20060210615A1 (en) * 2003-08-07 2006-09-21 Frank Theobald Dermal or transdermal therapeutic system comprising an ormocer with barrier effect on a cover foil
DE10348046A1 (en) * 2003-10-16 2005-05-19 Beiersdorf Ag Production of transdermal or topical matrix, used in skin and wound care, involves reacting polymer matrix containing added liquid fatty ester, paraffin or silicone oil on carrier, extracting additive and applying active agent and adjuvent
ATE448828T1 (en) * 2003-10-27 2009-12-15 Univ Basel TRANSDERMAL DRUG DELIVERY SYSTEM
US8252321B2 (en) 2004-09-13 2012-08-28 Chrono Therapeutics, Inc. Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like
CA2580329C (en) 2004-09-13 2015-01-06 Chrono Therapeutics Inc. Biosynchronous transdermal drug delivery
US8372040B2 (en) 2005-05-24 2013-02-12 Chrono Therapeutics, Inc. Portable drug delivery device including a detachable and replaceable administration or dosing element
DE102006054731B4 (en) * 2006-11-21 2013-02-28 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system for administration of the active ingredient buprenorphine and use thereof in pain therapy
DE102007041557B4 (en) * 2007-08-29 2011-03-31 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system containing elongated hollow bodies
WO2013006643A1 (en) 2011-07-06 2013-01-10 The Parkinson's Institute Compositions and methods for treatment of symptoms in parkinson's disease patients
MX352795B (en) 2011-12-12 2017-12-07 Lts Lohmann Therapie Systeme Ag Transdermal delivery system comprising buprenorphine.
US10105487B2 (en) 2013-01-24 2018-10-23 Chrono Therapeutics Inc. Optimized bio-synchronous bioactive agent delivery system
EA201592246A1 (en) 2013-06-04 2016-05-31 Лтс Лохманн Терапи-Системе Аг TRANSDERMAL DELIVERY SYSTEM
AU2016211330A1 (en) 2015-01-28 2017-08-03 Chrono Therapeutics Inc. Drug delivery methods and systems
JP2018511127A (en) 2015-03-12 2018-04-19 クロノ セラピューティクス インコーポレイテッドＣｈｒｏｎｏ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． Craving input and support system
JP2020503950A (en) 2017-01-06 2020-02-06 クロノ セラピューティクス インコーポレイテッドＣｈｒｏｎｏ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． Device and method for transdermal drug delivery
AU2019279884A1 (en) 2018-05-29 2020-12-10 Morningside Venture Investments Limited Drug delivery methods and systems
DE102018118507A1 (en) * 2018-07-31 2020-02-06 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system for the delivery of scopolamine without a membrane

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2153533C3 (en) * 1971-10-27 1974-12-12 Varta Batterie Ag, 3000 Hannover Electric accumulator cell
DE3333240A1 (en) * 1983-09-12 1985-03-28 Schering AG, 1000 Berlin und 4709 Bergkamen MEDIUM FOR TRANSDERMAL APPLICATION OF MEDICINAL PRODUCTS
DE3685895T2 (en) * 1985-02-25 1992-12-24 Univ Rutgers DOSING SYSTEM FOR TRANSDERMAL ABSORPTION OF DRUG ACTIVE SUBSTANCES.
US4883669A (en) * 1985-02-25 1989-11-28 Rutgers, The State University Of New Jersey Transdermal absorption dosage unit for estradiol and other estrogenic steroids and process for administration

Also Published As

Publication number Publication date
DE50001450D1 (en) 2003-04-17
KR20020015359A (en) 2002-02-27
IL147247A (en) 2006-12-31
DE19958554A1 (en) 2001-01-11
DE122006000008I1 (en) 2006-06-29
KR100685553B1 (en) 2007-02-22
ZA200110455B (en) 2002-10-16
DE19958554C2 (en) 2002-06-13

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