AR018062A1 - Formulacion farmaceutica liquida que contiene zotepina - Google Patents
Formulacion farmaceutica liquida que contiene zotepinaInfo
- Publication number
- AR018062A1 AR018062A1 ARP990100471A ARP990100471A AR018062A1 AR 018062 A1 AR018062 A1 AR 018062A1 AR P990100471 A ARP990100471 A AR P990100471A AR P990100471 A ARP990100471 A AR P990100471A AR 018062 A1 AR018062 A1 AR 018062A1
- Authority
- AR
- Argentina
- Prior art keywords
- acid
- zotepine
- liquid
- volume
- diluent
- Prior art date
Links
- HDOZVRUNCMBHFH-UHFFFAOYSA-N zotepine Chemical compound CN(C)CCOC1=CC2=CC=CC=C2SC2=CC=C(Cl)C=C12 HDOZVRUNCMBHFH-UHFFFAOYSA-N 0.000 title abstract 7
- 239000007788 liquid Substances 0.000 title abstract 5
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 6
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 abstract 6
- 229960004496 zotepine Drugs 0.000 abstract 6
- 239000003085 diluting agent Substances 0.000 abstract 4
- 239000002202 Polyethylene glycol Substances 0.000 abstract 3
- 239000004310 lactic acid Substances 0.000 abstract 3
- 235000014655 lactic acid Nutrition 0.000 abstract 3
- 150000007524 organic acids Chemical class 0.000 abstract 3
- 229920001223 polyethylene glycol Polymers 0.000 abstract 3
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 abstract 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 abstract 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 abstract 2
- 235000015165 citric acid Nutrition 0.000 abstract 2
- 239000012669 liquid formulation Substances 0.000 abstract 2
- 239000001630 malic acid Substances 0.000 abstract 2
- 235000011090 malic acid Nutrition 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- RTBFRGCFXZNCOE-UHFFFAOYSA-N 1-methylsulfonylpiperidin-4-one Chemical compound CS(=O)(=O)N1CCC(=O)CC1 RTBFRGCFXZNCOE-UHFFFAOYSA-N 0.000 abstract 1
- HLLSOEKIMZEGFV-UHFFFAOYSA-N 4-(dibutylsulfamoyl)benzoic acid Chemical compound CCCCN(CCCC)S(=O)(=O)C1=CC=C(C(O)=O)C=C1 HLLSOEKIMZEGFV-UHFFFAOYSA-N 0.000 abstract 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- JFCQEDHGNNZCLN-UHFFFAOYSA-N anhydrous glutaric acid Natural products OC(=O)CCCC(O)=O JFCQEDHGNNZCLN-UHFFFAOYSA-N 0.000 abstract 1
- 235000010323 ascorbic acid Nutrition 0.000 abstract 1
- 239000011668 ascorbic acid Substances 0.000 abstract 1
- 229960005070 ascorbic acid Drugs 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 abstract 1
- 235000013305 food Nutrition 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000001530 fumaric acid Substances 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 239000008159 sesame oil Substances 0.000 abstract 1
- 235000011803 sesame oil Nutrition 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000004334 sorbic acid Substances 0.000 abstract 1
- 235000010199 sorbic acid Nutrition 0.000 abstract 1
- 229940075582 sorbic acid Drugs 0.000 abstract 1
- 235000002906 tartaric acid Nutrition 0.000 abstract 1
- 239000011975 tartaric acid Substances 0.000 abstract 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9802617.2A GB9802617D0 (en) | 1998-02-07 | 1998-02-07 | Pharmaceutical formulation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR018062A1 true AR018062A1 (es) | 2001-10-31 |
Family
ID=10826622
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990100471A AR018062A1 (es) | 1998-02-07 | 1999-02-04 | Formulacion farmaceutica liquida que contiene zotepina |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US6239165B1 (cs) |
| EP (1) | EP1054666B1 (cs) |
| JP (1) | JP2002502818A (cs) |
| KR (1) | KR20010040717A (cs) |
| AR (1) | AR018062A1 (cs) |
| AT (1) | ATE227988T1 (cs) |
| AU (1) | AU2720099A (cs) |
| BG (1) | BG104682A (cs) |
| BR (1) | BR9907644A (cs) |
| CA (1) | CA2320475A1 (cs) |
| CO (1) | CO4970815A1 (cs) |
| CZ (1) | CZ291975B6 (cs) |
| DE (1) | DE69904021T2 (cs) |
| DK (1) | DK1054666T3 (cs) |
| ES (1) | ES2188135T3 (cs) |
| GB (1) | GB9802617D0 (cs) |
| HR (1) | HRP20000579A2 (cs) |
| HU (1) | HUP0100769A3 (cs) |
| PL (1) | PL342213A1 (cs) |
| PT (1) | PT1054666E (cs) |
| SK (1) | SK11472000A3 (cs) |
| TR (1) | TR200002288T2 (cs) |
| WO (1) | WO1999039709A1 (cs) |
| ZA (1) | ZA99918B (cs) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102006032427A1 (de) * | 2006-07-13 | 2008-01-17 | Neuraxpharm Arzneimittel Gmbh U. Co. Kg | Verwendung von Zusammensetzungen von Clozapin, Quetiapin, schwer oder sehr schwer löslichen Säureadditionssalzen von Quetiapin und/oder Olanzapin zur Herstellung von Lösungen zur oralen Verabreichung |
| DE102006032426A1 (de) * | 2006-07-13 | 2008-01-17 | Neuraxpharm Arzneimittel Gmbh U. Co. Kg | Verwendung von Zusammensetzungen von Clozapin, Quetiapin, schwer oder sehr schwer löslichen Säureadditionssalzen von Quetiapin und/oder Olanzapin zur Herstellung von Lösungen zur oralen Verabreichung |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1247067A (en) * | 1968-02-16 | 1971-09-22 | Fujisawa Pharmaceutical Co | Tricyclic enol ether compounds and the preparation thereof |
| JPS5191315A (ja) * | 1975-02-06 | 1976-08-10 | Anteinaensantoruperizonshirotsupunoseizoho | |
| JPS5852220A (ja) * | 1981-09-24 | 1983-03-28 | Fujisawa Pharmaceut Co Ltd | 血清尿酸値低下剤 |
| JPH07116039B2 (ja) * | 1988-01-11 | 1995-12-13 | オール薬品工業株式会社 | 安定な塩酸トリメトキノール内用液剤 |
| ZA90341B (en) * | 1989-01-23 | 1990-10-31 | Merrell Dow Pharma | Liquid pharmaceutical composition for piperidinoalkanol derivatives |
| US5462932A (en) * | 1994-05-17 | 1995-10-31 | Merck & Co., Inc. | Oral liquid alendronate formulations |
| JPH0827034A (ja) * | 1994-07-14 | 1996-01-30 | Nikken Chem Co Ltd | エリスリトール含有内用液剤 |
| EP0733368A1 (en) * | 1995-03-24 | 1996-09-25 | Eli Lilly And Company | Granule fomulation for olanzapine |
| GB9526264D0 (en) * | 1995-12-21 | 1996-02-21 | Knoll Ag | Medical treatment |
| JPH09286723A (ja) * | 1996-04-19 | 1997-11-04 | Takeda Chem Ind Ltd | 改善された経口液剤 |
-
1998
- 1998-02-07 GB GBGB9802617.2A patent/GB9802617D0/en not_active Ceased
-
1999
- 1999-01-27 DK DK99907436T patent/DK1054666T3/da active
- 1999-01-27 DE DE69904021T patent/DE69904021T2/de not_active Expired - Fee Related
- 1999-01-27 KR KR1020007008599A patent/KR20010040717A/ko not_active Withdrawn
- 1999-01-27 US US09/600,980 patent/US6239165B1/en not_active Expired - Fee Related
- 1999-01-27 TR TR2000/02288T patent/TR200002288T2/xx unknown
- 1999-01-27 AT AT99907436T patent/ATE227988T1/de not_active IP Right Cessation
- 1999-01-27 ES ES99907436T patent/ES2188135T3/es not_active Expired - Lifetime
- 1999-01-27 PL PL99342213A patent/PL342213A1/xx unknown
- 1999-01-27 BR BR9907644-6A patent/BR9907644A/pt not_active IP Right Cessation
- 1999-01-27 EP EP99907436A patent/EP1054666B1/en not_active Expired - Lifetime
- 1999-01-27 HR HR20000579A patent/HRP20000579A2/hr not_active Application Discontinuation
- 1999-01-27 CZ CZ20002846A patent/CZ291975B6/cs not_active IP Right Cessation
- 1999-01-27 JP JP2000530208A patent/JP2002502818A/ja active Pending
- 1999-01-27 CA CA002320475A patent/CA2320475A1/en not_active Abandoned
- 1999-01-27 AU AU27200/99A patent/AU2720099A/en not_active Abandoned
- 1999-01-27 WO PCT/EP1999/000533 patent/WO1999039709A1/en not_active Ceased
- 1999-01-27 HU HU0100769A patent/HUP0100769A3/hu unknown
- 1999-01-27 PT PT99907436T patent/PT1054666E/pt unknown
- 1999-01-27 SK SK1147-2000A patent/SK11472000A3/sk unknown
- 1999-02-04 AR ARP990100471A patent/AR018062A1/es not_active Application Discontinuation
- 1999-02-04 CO CO99006457A patent/CO4970815A1/es unknown
- 1999-02-05 ZA ZA9900918A patent/ZA99918B/xx unknown
-
2000
- 2000-08-09 BG BG104682A patent/BG104682A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GB9802617D0 (en) | 1998-04-01 |
| EP1054666B1 (en) | 2002-11-20 |
| EP1054666A1 (en) | 2000-11-29 |
| ATE227988T1 (de) | 2002-12-15 |
| BR9907644A (pt) | 2000-11-14 |
| CA2320475A1 (en) | 1999-08-12 |
| BG104682A (bg) | 2001-05-31 |
| ES2188135T3 (es) | 2003-06-16 |
| HK1033088A1 (en) | 2001-08-17 |
| TR200002288T2 (tr) | 2000-12-21 |
| US6239165B1 (en) | 2001-05-29 |
| HUP0100769A2 (hu) | 2001-12-28 |
| AU2720099A (en) | 1999-08-23 |
| HUP0100769A3 (en) | 2002-04-29 |
| ZA99918B (en) | 2000-08-07 |
| SK11472000A3 (sk) | 2001-08-06 |
| CZ20002846A3 (cs) | 2000-12-13 |
| KR20010040717A (ko) | 2001-05-15 |
| HRP20000579A2 (en) | 2001-04-30 |
| DE69904021D1 (de) | 2003-01-02 |
| CO4970815A1 (es) | 2000-11-07 |
| PL342213A1 (en) | 2001-05-21 |
| JP2002502818A (ja) | 2002-01-29 |
| PT1054666E (pt) | 2003-03-31 |
| DE69904021T2 (de) | 2003-04-30 |
| CZ291975B6 (cs) | 2003-06-18 |
| DK1054666T3 (da) | 2003-03-17 |
| WO1999039709A1 (en) | 1999-08-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |