AP610A - Process for the preparation of a salt of clavulanic acid. - Google Patents

Process for the preparation of a salt of clavulanic acid. Download PDF

Info

Publication number
AP610A
AP610A APAP/P/1996/000838A AP9600838A AP610A AP 610 A AP610 A AP 610A AP 9600838 A AP9600838 A AP 9600838A AP 610 A AP610 A AP 610A
Authority
AP
ARIPO
Prior art keywords
solution
salt
clavulanic acid
process according
water
Prior art date
Application number
APAP/P/1996/000838A
Other languages
English (en)
Other versions
AP9600838A0 (en
Inventor
Michael Alan Cook
Geoffrey Clive Webb
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of AP9600838A0 publication Critical patent/AP9600838A0/xx
Application granted granted Critical
Publication of AP610A publication Critical patent/AP610A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
APAP/P/1996/000838A 1994-02-02 1995-01-31 Process for the preparation of a salt of clavulanic acid. AP610A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9401969A GB9401969D0 (en) 1994-02-02 1994-02-02 Process
PCT/GB1995/000191 WO1995021173A1 (en) 1994-02-02 1995-01-31 Process for the preparation of a salt of clavulanic acid

Publications (2)

Publication Number Publication Date
AP9600838A0 AP9600838A0 (en) 1996-07-31
AP610A true AP610A (en) 1997-09-04

Family

ID=10749727

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1996/000838A AP610A (en) 1994-02-02 1995-01-31 Process for the preparation of a salt of clavulanic acid.

Country Status (32)

Country Link
US (1) US5965728A (sk)
EP (1) EP0741732B1 (sk)
JP (1) JP4074336B2 (sk)
KR (1) KR100388769B1 (sk)
CN (1) CN1065246C (sk)
AP (1) AP610A (sk)
AT (1) ATE202358T1 (sk)
AU (1) AU688849B2 (sk)
BG (1) BG63307B1 (sk)
BR (1) BR9506919A (sk)
CA (1) CA2182504C (sk)
CZ (1) CZ294005B6 (sk)
DE (1) DE69521415T2 (sk)
DK (1) DK0741732T3 (sk)
ES (1) ES2159626T3 (sk)
FI (1) FI111949B (sk)
GB (1) GB9401969D0 (sk)
GR (1) GR3036602T3 (sk)
HK (1) HK1012373A1 (sk)
HU (1) HU226597B1 (sk)
MX (1) MX9603204A (sk)
NO (1) NO314505B1 (sk)
NZ (1) NZ278927A (sk)
OA (1) OA10587A (sk)
PL (1) PL181451B1 (sk)
PT (1) PT741732E (sk)
RO (1) RO115730B1 (sk)
RU (1) RU2140418C1 (sk)
SI (1) SI0741732T1 (sk)
SK (1) SK282544B6 (sk)
UA (1) UA48944C2 (sk)
WO (1) WO1995021173A1 (sk)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT400033B (de) 1992-03-10 1995-09-25 Biochemie Gmbh Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
SI9400107A (en) 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
GB9500977D0 (en) * 1995-01-19 1995-03-08 Smithkline Beecham Plc Novel process
SI9500134B (sl) 1995-04-20 2004-04-30 Lek, Postopek za pripravo čistih alkalijskih soli klavulanske kisline
GB9515809D0 (en) * 1995-08-02 1995-10-04 Smithkline Beecham Plc Process
AT403375B (de) * 1995-11-15 1998-01-26 Biochemie Gmbh Verfahren zur fällung von alkalisalzen der clavulansäure
US6414142B1 (en) * 1996-06-13 2002-07-02 Smithkline Beecham Corporation Process for preparing potassium clavulanate
PT867515E (pt) 1997-03-24 2000-05-31 Cipan Companhia Ind P De Antib Processo para isolar um sal de acido clavulanico e de um metal alcalino farmaceuticamente aceitavel
WO1998042858A1 (en) * 1997-03-24 1998-10-01 Cipan-Companhia Industrial Produtora De Antibióticos, S.A. Process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid
DZ2456A1 (fr) * 1997-04-04 2003-01-18 Smithkline Beecham Plc Procédé de préparation de sels de l'acide clavulanique.
WO2003011450A1 (en) 2001-08-02 2003-02-13 Lg Life Sciences Limited Processes for the production of amino-protected derivatives of 4-aminomethylene-pyrrolidin-3-one and/or 4-aminomethylene-pyrrolidin-3-alkoxyimino derivatives and/or gemifloxacin or a salt thereof
JP2019527214A (ja) 2016-07-14 2019-09-26 アカオジェン インコーポレイテッド 細菌感染症の処置における使用のためのセフチブテンとクラブラン酸の組み合わせ
CN108822134B (zh) * 2018-04-25 2021-06-25 国药集团威奇达药业有限公司 克拉维酸叔丁胺盐的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0026044A1 (en) * 1979-08-24 1981-04-01 Beecham Group Plc Amine salt of clavulanic acid, its preparation and use
EP0153843A2 (en) * 1984-02-23 1985-09-04 United Kingdom Atomic Energy Authority Improvements in and relating to fluidic contactors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1508977A (en) * 1974-04-20 1978-04-26 Beecham Group Ltd Beta-lactam antibiotic from streptomyces clavuligerus
GB1563103A (en) * 1975-10-13 1980-03-19 Beecham Group Ltd Process for the preparation of clavulanic acid

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0026044A1 (en) * 1979-08-24 1981-04-01 Beecham Group Plc Amine salt of clavulanic acid, its preparation and use
EP0153843A2 (en) * 1984-02-23 1985-09-04 United Kingdom Atomic Energy Authority Improvements in and relating to fluidic contactors

Also Published As

Publication number Publication date
ES2159626T3 (es) 2001-10-16
FI111949B (fi) 2003-10-15
NZ278927A (en) 1998-02-26
DK0741732T3 (da) 2001-10-15
FI963050A (fi) 1996-10-01
CN1144528A (zh) 1997-03-05
GB9401969D0 (en) 1994-03-30
MX9603204A (es) 1997-03-29
PT741732E (pt) 2001-11-30
HU226597B1 (en) 2009-04-28
DE69521415D1 (de) 2001-07-26
PL181451B1 (en) 2001-07-31
BG63307B1 (bg) 2001-09-28
KR100388769B1 (ko) 2003-09-02
JP4074336B2 (ja) 2008-04-09
EP0741732B1 (en) 2001-06-20
AU688849B2 (en) 1998-03-19
AP9600838A0 (en) 1996-07-31
AU1541295A (en) 1995-08-21
BG100765A (en) 1997-09-30
US5965728A (en) 1999-10-12
JPH09508411A (ja) 1997-08-26
HUT74885A (en) 1997-02-28
HK1012373A1 (en) 1999-07-30
CZ294005B6 (cs) 2004-09-15
DE69521415T2 (de) 2002-05-29
HU9602128D0 (en) 1996-09-30
BR9506919A (pt) 1997-09-30
PL315782A1 (en) 1996-12-09
CN1065246C (zh) 2001-05-02
UA48944C2 (uk) 2002-09-16
FI963050A0 (fi) 1996-08-01
NO963217D0 (no) 1996-08-01
RU2140418C1 (ru) 1999-10-27
EP0741732A1 (en) 1996-11-13
SK100396A3 (en) 1996-12-04
NO963217L (no) 1996-10-01
RO115730B1 (ro) 2000-05-30
NO314505B1 (no) 2003-03-31
SK282544B6 (sk) 2002-10-08
CZ229496A3 (en) 1997-01-15
GR3036602T3 (en) 2001-12-31
WO1995021173A1 (en) 1995-08-10
CA2182504C (en) 2008-04-08
ATE202358T1 (de) 2001-07-15
OA10587A (en) 2002-07-10
CA2182504A1 (en) 1995-08-10
SI0741732T1 (sk) 2001-10-31

Similar Documents

Publication Publication Date Title
AP610A (en) Process for the preparation of a salt of clavulanic acid.
RU2206613C2 (ru) Способ выделения клавулановой кислоты
EP0813536B1 (en) Process for the preparation of pharmaceutically acceptable salts of clavulanic acid
EP0843680B1 (en) Process for the preparation of potassium clavulanate
CA2210748C (en) Clavulanic acid extraction process
AU706196C (en) Clavulanic acid extraction process