AP200603591A0 - 5,7- diaminopyrazolo '4,3- dipyrimidines with pde-5 inhibiting activity. - Google Patents

5,7- diaminopyrazolo '4,3- dipyrimidines with pde-5 inhibiting activity.

Info

Publication number
AP200603591A0
AP200603591A0 AP200603591A AP200603591A AP200603591A0 AP 200603591 A0 AP200603591 A0 AP 200603591A0 AP 200603591 A AP200603591 A AP 200603591A AP 200603591 A AP200603591 A AP 200603591A AP 200603591 A0 AP200603591 A0 AP 200603591A0
Authority
AP
ARIPO
Prior art keywords
dipyrimidines
diaminopyrazolo
pde
inhibiting activity
inhibiting
Prior art date
Application number
AP200603591A
Other versions
AP2227A (en
Inventor
Andrew Simon Bell
David Graham Brown
Kevin Neil Dack
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to GBGB0327319.0A priority Critical patent/GB0327319D0/en
Application filed by Pfizer filed Critical Pfizer
Priority to PCT/IB2004/003747 priority patent/WO2005049616A1/en
Publication of AP200603591A0 publication Critical patent/AP200603591A0/en
Application granted granted Critical
Publication of AP2227A publication Critical patent/AP2227A/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of products other than chlorine, adipic acid, caprolactam, or chlorodifluoromethane, e.g. bulk or fine chemicals or pharmaceuticals
    • Y02P20/58Recycling
    • Y02P20/582Recycling of unreacted starting or intermediate materials
AP200603591A 2003-11-24 2004-11-12 5,7-diaminopyrazolo [4,3-d]pyrimidines with PDE-5 inhibiting activity. AP2227A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GBGB0327319.0A GB0327319D0 (en) 2003-11-24 2003-11-24 Novel pharmaceuticals
PCT/IB2004/003747 WO2005049616A1 (en) 2003-11-24 2004-11-12 5,7-DIAMINOPYRAZOLO [4,3-d] PYRIMIDINES WITH PDE-5 INHIBITING ACTIVITY

Publications (2)

Publication Number Publication Date
AP200603591A0 true AP200603591A0 (en) 2006-04-30
AP2227A AP2227A (en) 2011-03-29

Family

ID=29764364

Family Applications (1)

Application Number Title Priority Date Filing Date
AP200603591A AP2227A (en) 2003-11-24 2004-11-12 5,7-diaminopyrazolo [4,3-d]pyrimidines with PDE-5 inhibiting activity.

Country Status (42)

Country Link
EP (1) EP1689751B1 (en)
JP (1) JP4056015B2 (en)
KR (2) KR100848216B1 (en)
CN (4) CN101362764B (en)
AP (1) AP2227A (en)
AR (1) AR046711A1 (en)
AT (1) AT485297T (en)
AU (1) AU2004290643B2 (en)
BR (1) BRPI0416869A (en)
CA (1) CA2546987C (en)
CR (1) CR8416A (en)
CY (1) CY1110933T1 (en)
DE (1) DE602004029705D1 (en)
DK (1) DK1689751T3 (en)
EA (1) EA011772B1 (en)
EC (1) ECSP066580A (en)
ES (1) ES2351622T3 (en)
GB (1) GB0327319D0 (en)
GE (1) GEP20084528B (en)
HK (2) HK1099286A1 (en)
HR (1) HRP20100651T1 (en)
IL (1) IL175433A (en)
IS (1) IS8406A (en)
MA (1) MA28172A1 (en)
ME (1) ME01216B (en)
MX (1) MXPA06005914A (en)
MY (1) MY140872A (en)
NL (1) NL1027568C2 (en)
NO (1) NO336526B1 (en)
NZ (1) NZ548097A (en)
OA (1) OA13289A (en)
PA (1) PA8617701A1 (en)
PE (1) PE10612005A1 (en)
PT (1) PT1689751E (en)
RS (1) RS51556B (en)
SG (1) SG133614A1 (en)
TN (1) TNSN06154A1 (en)
TW (1) TWI265031B (en)
UA (1) UA81994C2 (en)
UY (1) UY28625A1 (en)
WO (1) WO2005049616A1 (en)
ZA (1) ZA200602899B (en)

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AR051092A1 (en) 2004-09-20 2006-12-20 Xenon Pharmaceuticals Inc Heterocyclic derivatives and their use as inhibitors of stearoyl-coa
CA2580762A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as therapeutic agents
CA2580844A1 (en) 2004-09-20 2006-03-30 Xenon Pharmaceuticals Inc. Heterocyclic derivatives and their use as mediators of stearoyl-coa desaturase
TW200626139A (en) 2004-09-20 2006-08-01 Xenon Pharmaceuticals Inc Heterocyclic derivatives and their use as therapeutic agents
EP2289510A1 (en) 2004-09-20 2011-03-02 Xenon Pharmaceuticals Inc. Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes
CA2585557C (en) * 2004-10-28 2009-08-18 Pharmacia & Upjohn Company Llc Pyrazolo[4,3-d] pyrimidine derivatives useful as pde-5 inhibitors
AU2006245416B2 (en) 2005-05-12 2012-02-23 Pfizer Inc. Anhydrous crystalline forms of N-[1-(2-ethoxyethyl)-5-(N-ethyl-N-methylamino)-7-(4-methylpyridin-2-yl-amino)-1H-pyrazolo[4,3-d]pyrimidine-3-carbonyl]methanesulfonamide
CA2618646A1 (en) 2005-06-03 2007-11-15 Xenon Pharmaceuticals Inc. Aminothiazole derivatives as human stearoyl-coa desaturase inhibitors
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DE102005050377A1 (en) * 2005-10-21 2007-04-26 Bayer Healthcare Ag Heterocyclic compounds and their use
NL2000291C2 (en) * 2005-11-10 2009-02-17 Pfizer Prod Inc 1- (1- (2-ethoxyethyl) -3-ethyl-7- (4-methylpyridin-2-ylamino) -1H-pyrazolo (4,3-d) pyrimidin-5-yl) piperidine-4-carboxylic acid and salts thereof.
ES2562428T3 (en) 2005-12-15 2016-03-04 Rigel Pharmaceuticals, Inc. Kinase inhibitors and their uses
EP1820502A1 (en) * 2006-02-10 2007-08-22 Laboratorios Del Dr. Esteve, S.A. Active substance combination comprising azolylcarbinol compounds
WO2007113243A2 (en) * 2006-03-31 2007-10-11 Investigación Y Clínica Andrológicas S.L. Use of pde 5 inhibitors for the treatment of overactive bladder
WO2008132589A1 (en) * 2007-05-01 2008-11-06 Pfizer Limited Combinations comprising pregabalin
WO2009050554A2 (en) * 2007-10-19 2009-04-23 Pfizer Inc. Pyrazolo [4, 3d] pyrimidine derivatives for use in promoting functional recovery
DE102008063992A1 (en) * 2008-12-19 2010-09-02 Lerner, Zinoviy, Dipl.-Ing. New substituted aliphatic pyrazolopyridines and their use
ES2602794T3 (en) 2011-03-31 2017-02-22 Pfizer Inc Pyridinones novel bicyclic
WO2012172449A1 (en) 2011-06-13 2012-12-20 Pfizer Inc. Lactams as beta secretase inhibitors
JP6043355B2 (en) 2011-08-31 2016-12-14 ファイザー・インク Hexahydropyrazolo Bruno [3,4-d] [1,3] thiazine-2-amine Compound
CA2872154C (en) 2012-05-04 2016-08-23 Pfizer Inc. Heterocyclic substituted hexahydropyrano [3,4-d] [1,3] thiazin-2-amine compounds as inhibitors of app, bace1 and bace2
US9260455B2 (en) 2012-09-20 2016-02-16 Pfizer Inc. Alkyl-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
PL2897956T3 (en) 2012-09-21 2017-05-31 Pfizer Inc. Novel bicyclic pyridinones
WO2014091352A1 (en) 2012-12-11 2014-06-19 Pfizer Inc. Hexahydropyrano [3,4-d][1,3]thiazin-2-amine compounds as inhibitors of bace1
JP6162820B2 (en) 2012-12-19 2017-07-12 ファイザー・インク Carbocyclic and heterocyclic substituted hexahydropyrazolo Bruno [3,4-d] [1,3] thiazine-2-amine Compound
CA2897678A1 (en) 2013-02-13 2014-08-21 Pfizer Inc. Heteroaryl-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
US9233981B1 (en) 2013-02-15 2016-01-12 Pfizer Inc. Substituted phenyl hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
MX2015010714A (en) 2013-02-19 2016-06-14 Pfizer Azabenzimidazole compounds as inhibitors of pde4 isozymes for the treatment of cns and other disorders.
WO2015049616A1 (en) 2013-10-04 2015-04-09 Pfizer Inc. Novel bicyclic pyridinones as gamma-secretase modulators
EP3083598A1 (en) * 2013-12-20 2016-10-26 Bayer Pharma Aktiengesellschaft Glucose transport inhibitors
CN106211770B (en) 2014-04-01 2018-02-06 辉瑞公司 As γ- secretase modulators and chromene 1,1A, 2,7B- tetrahydrocyclopropa [c] chromene pyridopyrazinedione
AP201609521A0 (en) * 2014-04-04 2016-10-31 Lundbeck & Co As H Halogenated quinazolin-thf-amines as pde1 inhibitors
EP3129388A1 (en) 2014-04-10 2017-02-15 Pfizer Inc 2-AMINO-6-METHYL-4,4a,5,6-TETRAHYDROPYRANO[3,4-d][1,3]THIAZIN-8a(8H)-YL-1,3-THIAZOL-4-YL AMIDES
JP2017521460A (en) 2014-07-24 2017-08-03 ファイザー・インク Pyrazolopyrimidine compound
PE02952017A1 (en) 2014-08-06 2017-03-30 Pfizer Compounds imidazopyridazine
WO2016125048A1 (en) 2015-02-03 2016-08-11 Pfizer Inc. Novel cyclopropabenzofuranyl pyridopyrazinediones
KR20180004817A (en) 2015-06-17 2018-01-12 화이자 인코포레이티드 Tricyclic compound and a phosphine poda yieseu atmospheres their use as inhibitors
WO2017051294A1 (en) 2015-09-24 2017-03-30 Pfizer Inc. N-[2-(3-amino-2,5-dimethyl-1,1-dioxido-5,6-dihydro-2h-1,2,4-thiadiazin-5-yl)-1,3-thiazol-4-yl] amides useful as bace inhibitors
BR112018003489A2 (en) 2015-09-24 2018-09-25 Pfizer N- [2- (2-amino-6,6-disubstituted-4,4a, 5,6-tetrahydro-pyran [3,4-d] [1,3] thiazin-8a (8H) -yl) -1 3-thiazol-4-yl] amide
JP2018531924A (en) 2015-09-24 2018-11-01 ファイザー・インク Tetrahydropyrano [3,4-d] [1,3] oxazine derivatives, and their use as bace inhibitors
CN108699080A (en) 2016-02-23 2018-10-23 辉瑞公司 6,7-dihydro-5h-pyrazolo[5,1-b][1,3]oxazine-2-carboxamide compounds
AU2017286868A1 (en) 2016-07-01 2019-02-21 Pfizer Inc. 5,7-dihydro-pyrrolo-pyridine derivatives for treating neurological and neurodegenerative diseases
WO2018234953A1 (en) 2017-06-22 2018-12-27 Pfizer Inc. Dihydro-pyrrolo-pyridine derivatives

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TW444018B (en) * 1992-12-17 2001-07-01 Pfizer Pyrazolopyrimidines
WO2000024745A1 (en) * 1998-10-23 2000-05-04 Pfizer Limited PYRAZOLOPYRIMIDINONE cGMP PDE5 INHIBITORS FOR THE TREATMENT OF SEXUAL DYSFUNCTION
GB9823102D0 (en) 1998-10-23 1998-12-16 Pfizer Ltd Pharmaceutically active compounds
DE10031236A1 (en) * 2000-06-27 2002-01-10 Qiagen Gmbh Use of carboxylic acids and other additives in combination with cationic compounds for stabilizing nucleic acids in biological materials
DE10031584A1 (en) * 2000-06-29 2002-01-10 Merck Patent Gmbh 5-aminoalkyl-pyrazolo [4,3-d] pyrimidine
DE60237425D1 (en) * 2002-03-28 2010-10-07 Univerzita Palackeho V Olomouc PyrazoloÄ4,3-dÜpyrimidine, to processes for their preparation and therapeutic use
DK1620437T3 (en) * 2003-04-29 2009-08-24 Pfizer Ltd 5,7-diaminopyrazolo-4,3-d-pyrimidines that are useful for treating hypertension

Also Published As

Publication number Publication date
UY28625A1 (en) 2005-06-30
NO20062950L (en) 2006-08-23
KR100893999B1 (en) 2009-04-20
CA2546987C (en) 2009-05-12
NL1027568A1 (en) 2005-05-26
DE602004029705D1 (en) 2010-12-02
CN101362765A (en) 2009-02-11
PA8617701A1 (en) 2005-08-04
ME01216B (en) 2013-03-20
TW200520758A (en) 2005-07-01
MY140872A (en) 2010-01-29
MXPA06005914A (en) 2006-06-27
AP2227A (en) 2011-03-29
JP4056015B2 (en) 2008-03-05
CN101362764B (en) 2011-04-20
CN101647802A (en) 2010-02-17
IL175433A (en) 2011-08-31
AR046711A1 (en) 2005-12-21
WO2005049616A8 (en) 2006-06-01
TNSN06154A1 (en) 2007-11-15
BRPI0416869A (en) 2007-03-27
SI1689751T1 (en) 2011-01-31
IS8406A (en) 2006-04-10
CA2546987A1 (en) 2005-06-02
SG133614A1 (en) 2007-07-30
ZA200602899B (en) 2007-07-25
TWI265031B (en) 2006-11-01
HRP20100651T1 (en) 2011-01-31
OA13289A (en) 2007-01-31
EP1689751A1 (en) 2006-08-16
AU2004290643B2 (en) 2008-08-07
AU2004290643A1 (en) 2005-06-02
KR20080052666A (en) 2008-06-11
EA200600677A1 (en) 2006-12-29
JP2007512314A (en) 2007-05-17
GB0327319D0 (en) 2003-12-24
ECSP066580A (en) 2006-12-20
NZ548097A (en) 2008-12-24
CN101362764A (en) 2009-02-11
WO2005049616A1 (en) 2005-06-02
CN1882591A (en) 2006-12-20
RS51556B (en) 2011-06-30
UA81994C2 (en) 2008-02-25
HK1128917A1 (en) 2011-12-09
IL175433D0 (en) 2006-09-05
EA011772B1 (en) 2009-06-30
CN1882591B (en) 2011-08-10
PT1689751E (en) 2010-11-29
NL1027568C2 (en) 2005-11-30
KR100848216B1 (en) 2008-07-24
EP1689751B1 (en) 2010-10-20
PE10612005A1 (en) 2005-12-12
KR20070026334A (en) 2007-03-08
GEP20084528B (en) 2008-11-10
CR8416A (en) 2006-11-15
ES2351622T3 (en) 2011-02-08
NO336526B1 (en) 2015-09-21
AT485297T (en) 2010-11-15
MA28172A1 (en) 2006-09-01
CN101362765B (en) 2011-02-02
CY1110933T1 (en) 2015-06-10
HK1099286A1 (en) 2012-06-01
DK1689751T3 (en) 2011-01-17

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