WO2009073970A1 - A method for performing micro-perimetry exams based on a retinal volume image and a well registered fundus image - Google Patents
A method for performing micro-perimetry exams based on a retinal volume image and a well registered fundus image Download PDFInfo
- Publication number
- WO2009073970A1 WO2009073970A1 PCT/CA2008/002144 CA2008002144W WO2009073970A1 WO 2009073970 A1 WO2009073970 A1 WO 2009073970A1 CA 2008002144 W CA2008002144 W CA 2008002144W WO 2009073970 A1 WO2009073970 A1 WO 2009073970A1
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- WIPO (PCT)
- Prior art keywords
- perimetry
- points
- image
- retinal
- micro
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/02—Subjective types, i.e. testing apparatus requiring the active assistance of the patient
- A61B3/024—Subjective types, i.e. testing apparatus requiring the active assistance of the patient for determining the visual field, e.g. perimeter types
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/102—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for optical coherence tomography [OCT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/12—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
- A61B3/1225—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes using coherent radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/12—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
- A61B3/1241—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes specially adapted for observation of ocular blood flow, e.g. by fluorescein angiography
Definitions
- a method for performing micro-perimetry exams based on a retinal volume image and a well registered fundus image is based on a retinal volume image and a well registered fundus image.
- This invention relates to the field of ophthalmogical diagnostic testing, and in particular to a method of performing micro-perimetry.
- Micro-perimetry is a well known diagnostic test used in ophthalmology for testing a patient's visual function. Stimuli are presented to a region of interest in order to test its optical responsiveness. All micro-perimetry tests are based on some sort of fundus image either from a scanning laser ophthalmoscope (SLO), fundus video camera or some other similar technology.
- SLO scanning laser ophthalmoscope
- the fundus of an eye is the interior surface of the eye, opposite the lens, and includes the retina, optic disc, macula, and posterior pole.
- a fundus image the operator can place either standard perimetry patterns or manually created perimetry patterns.
- the operator can use the fundus image to place perimetry points around what can be seen as potential problem areas. This technique is extremely limited in that many pathologies are not visible in a fundus image; instead the pathology may only be visible when a volume of retinal tissue is imaged, that is the retinal tissue is viewed in section.
- three-dimensional volume imaging information obtained using three dimensional imaging equipment is scanned by the operator to select points of interest.
- the corresponding points are then mapped to a corresponding en- face image of the fundus or regions of interest.
- Optical coherence tomography is ideally suited for gathering this type of volume information.
- any other technology that can gather retinal volume information can be used; for example MRI would also work.
- OCT Optical Coherence Tomography
- Micro-perimetry needs some sort of fundus image in order to track patient eye movement so stimulus presentation is consistently located in the same location. After the operator has looked through the volume information to find points of interest to test with micro- perimetry and selected these areas of interest in the retinal volume image, and then mapped these point to corresponding locations on the fundus, the micro-perimetry examination can begin. To do this a fundus image that is aligned perfectly, or at least very well, with underlying retinal volume image is required. The mapping can be performed automatically by the computer or manually by the operator.
- a fundus photo or fundus video image would work well for this.
- An SLO image from a combined SLO-OCT machine would be ideal for its high detail and nearly automatic registration to a retinal volume OCT image.
- Figure 1 is a dual SLO/OCT image showing volume information together with an overlying fundus image
- FIG. 2 is a flow diagram illustration the operation of the method in accordance with the invention.
- Figure 1 shows an en-face image of the fundus of an eye, with sectional images obtained by OCT shown beside and below the en-face image.
- the image to the right is a cross section taken along the vertical axis
- the image below is a cross section taken along the horizontal axis.
- Such an image can be displayed on the display screen of OCT equipment.
- the en-face image is obtained using SLO (scanning laser ophthalmoscope), whereas the sectional images are obtained by OCT.
- SLO scanning laser ophthalmoscope
- the operator looks at the sectional OCT images to the right and below the main image to find points of interest, for example, particular points where some pathological condition may be noted. He or she then selects these points, for example, by pointing to them and clicking with a mouse.
- the computer forming part of the OCT equipment then automatically places marks (indicated by an X) at these points in the sectional images, and makes corresponding points appear on the en-face fundus image. This can be achieved with a computer in standard OCT/SLO equipment, for example the dual OCT/SLO analyzer sold by Ophthalmic Technologies Inc (OTI).
- Ophthalmic Technologies Inc Ophthalmic Technologies Inc
- Figure 2 illustrates the steps involved in performing a micro-perimetry examination.
- the operator creates an SLO en- face image of the retina using the dual OCT/SLO equipment.
- the operator uses the mouse to locate the section lines on the en- face image.
- the dual OCT equipment then shows a corresponding sectional view alongside the en-face image.
- the vertical section is shown to the right and the horizontal section is shown below. Moving the mouse moves the section lines horizontally and vertically over the image.
- the operator views the corresponding OCT images in alignment with the en- face image to look for points of interest.
- the operators then moves the section lines, looking at the corresponding sectional images, to identify additional points of interest, marking the points on the en-face image so that they are mapped to the points identified on the sectional images.
- the operator then performs a conventional perimetry test be presenting stimuli to the points that have been identified as being of interest on the en-face image, using the sectional images.
- the operator may map the points in the sectional images manually to the corresponding points in the en-face image.
- the operator then uses the perimetry marks surrounding the region of interest in the en- face image as a basis for performing a standard perimetry test.
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- Ophthalmology & Optometry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Eye Examination Apparatus (AREA)
Abstract
Description
Claims
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN200880119878.XA CN101969833B (en) | 2007-12-10 | 2008-12-10 | A method for performing micro-perimetry exams based on a retinal volume image and a well registered fundus image |
JP2010537219A JP5568725B2 (en) | 2007-12-10 | 2008-12-10 | Method for performing microfield measurement tests based on large volume retinal images and well-recorded fundus images |
CA2708332A CA2708332C (en) | 2007-12-10 | 2008-12-10 | A method for performing micro-perimetry exams based on a retinal volume image and a well registered fundus image |
EP08859934.5A EP2219512B1 (en) | 2007-12-10 | 2008-12-10 | A method for performing micro-perimetry exams based on a retinal volume image and a well registered fundus image |
US12/866,953 US8639004B2 (en) | 2007-12-10 | 2008-12-10 | Method for performing micro-perimetry exams based on a retinal volume image and a well registered fundus image |
HK11101190.3A HK1147050A1 (en) | 2007-12-10 | 2011-02-08 | A method for performing micro-perimetry exams based on a retinal volume image and a well registered fundus image |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1252607P | 2007-12-10 | 2007-12-10 | |
US61/012,526 | 2007-12-10 |
Publications (1)
Publication Number | Publication Date |
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WO2009073970A1 true WO2009073970A1 (en) | 2009-06-18 |
Family
ID=40755213
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CA2008/002144 WO2009073970A1 (en) | 2007-12-10 | 2008-12-10 | A method for performing micro-perimetry exams based on a retinal volume image and a well registered fundus image |
Country Status (7)
Country | Link |
---|---|
US (1) | US8639004B2 (en) |
EP (1) | EP2219512B1 (en) |
JP (1) | JP5568725B2 (en) |
CN (1) | CN101969833B (en) |
CA (1) | CA2708332C (en) |
HK (1) | HK1147050A1 (en) |
WO (1) | WO2009073970A1 (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2361547A1 (en) * | 2010-02-25 | 2011-08-31 | Oculus Optikgeräte GmbH | Perimetric method |
EP2449957A1 (en) * | 2010-11-05 | 2012-05-09 | Nidek Co., Ltd. | Control method of a fundus examination apparatus |
JP2012100713A (en) * | 2010-11-05 | 2012-05-31 | Nidek Co Ltd | Ophthalmologic apparatus |
CN103222848A (en) * | 2012-01-25 | 2013-07-31 | 佳能株式会社 | Image processing apparatus, and image processing method |
EP2672879A4 (en) * | 2011-01-28 | 2016-06-15 | Optovue Inc | Computer-aided diagnosis of retinal pathologies using frontal en-face views of optical coherence tomography |
EP2609851A4 (en) * | 2010-08-24 | 2017-08-16 | Kowa Company, Ltd. | Visual field examination system |
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JP6281177B2 (en) * | 2013-01-23 | 2018-02-21 | 株式会社ニデック | Ophthalmic imaging equipment |
US9872647B2 (en) * | 2015-04-17 | 2018-01-23 | The Curators Of The University Of Missouri | Detection of early stage alzheimer's disease and mild cognitive impairment |
JP6788397B2 (en) * | 2016-07-05 | 2020-11-25 | キヤノン株式会社 | Image processing device, control method of image processing device, and program |
CN107169309B (en) * | 2017-07-26 | 2018-04-13 | 北京为凡医疗信息技术有限公司 | Visual field detection method, system and detection device based on wear-type detection device |
JP7030455B2 (en) * | 2017-09-06 | 2022-03-07 | キヤノン株式会社 | Image processing equipment, image processing methods and programs |
CN115170503B (en) * | 2022-07-01 | 2023-12-19 | 上海市第一人民医院 | Fundus image visual field classification method and device based on decision rule and deep neural network |
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2008
- 2008-12-10 WO PCT/CA2008/002144 patent/WO2009073970A1/en active Application Filing
- 2008-12-10 CA CA2708332A patent/CA2708332C/en not_active Expired - Fee Related
- 2008-12-10 US US12/866,953 patent/US8639004B2/en active Active
- 2008-12-10 JP JP2010537219A patent/JP5568725B2/en active Active
- 2008-12-10 EP EP08859934.5A patent/EP2219512B1/en active Active
- 2008-12-10 CN CN200880119878.XA patent/CN101969833B/en active Active
-
2011
- 2011-02-08 HK HK11101190.3A patent/HK1147050A1/en unknown
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Cited By (11)
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EP2361547A1 (en) * | 2010-02-25 | 2011-08-31 | Oculus Optikgeräte GmbH | Perimetric method |
US8425039B2 (en) | 2010-02-25 | 2013-04-23 | Oculus Optikgeraete Gmbh | Perimetric method |
EP2609851A4 (en) * | 2010-08-24 | 2017-08-16 | Kowa Company, Ltd. | Visual field examination system |
EP2449957A1 (en) * | 2010-11-05 | 2012-05-09 | Nidek Co., Ltd. | Control method of a fundus examination apparatus |
JP2012100713A (en) * | 2010-11-05 | 2012-05-31 | Nidek Co Ltd | Ophthalmologic apparatus |
US8931904B2 (en) | 2010-11-05 | 2015-01-13 | Nidek Co., Ltd. | Control method of a fundus examination apparatus |
US9649022B2 (en) | 2010-11-05 | 2017-05-16 | Nidek Co., Ltd. | Control method of a fundus examination apparatus |
EP2672879A4 (en) * | 2011-01-28 | 2016-06-15 | Optovue Inc | Computer-aided diagnosis of retinal pathologies using frontal en-face views of optical coherence tomography |
CN103222848A (en) * | 2012-01-25 | 2013-07-31 | 佳能株式会社 | Image processing apparatus, and image processing method |
CN103222848B (en) * | 2012-01-25 | 2016-04-06 | 佳能株式会社 | Image processing equipment and image processing method |
US9566002B2 (en) | 2012-01-25 | 2017-02-14 | Canon Kabushiki Kaisha | Image processing apparatus, image processing method, and program |
Also Published As
Publication number | Publication date |
---|---|
EP2219512A1 (en) | 2010-08-25 |
JP2011505926A (en) | 2011-03-03 |
EP2219512A4 (en) | 2012-06-27 |
US8639004B2 (en) | 2014-01-28 |
CA2708332C (en) | 2015-03-24 |
US20120002856A1 (en) | 2012-01-05 |
CN101969833A (en) | 2011-02-09 |
HK1147050A1 (en) | 2011-07-29 |
CA2708332A1 (en) | 2009-06-18 |
CN101969833B (en) | 2015-04-22 |
JP5568725B2 (en) | 2014-08-13 |
EP2219512B1 (en) | 2013-09-25 |
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