WO2008024496A2 - Analytic plates with markable portions and methods of use - Google Patents
Analytic plates with markable portions and methods of use Download PDFInfo
- Publication number
- WO2008024496A2 WO2008024496A2 PCT/US2007/018786 US2007018786W WO2008024496A2 WO 2008024496 A2 WO2008024496 A2 WO 2008024496A2 US 2007018786 W US2007018786 W US 2007018786W WO 2008024496 A2 WO2008024496 A2 WO 2008024496A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- coating
- substrate
- developable
- opaque
- hydrophobic
- Prior art date
Links
- 238000000034 method Methods 0.000 title description 30
- 238000000576 coating method Methods 0.000 claims abstract description 297
- 239000011248 coating agent Substances 0.000 claims abstract description 256
- 239000000758 substrate Substances 0.000 claims abstract description 123
- 230000002209 hydrophobic effect Effects 0.000 claims description 68
- 239000007788 liquid Substances 0.000 claims description 64
- 239000011521 glass Substances 0.000 claims description 27
- 239000000463 material Substances 0.000 claims description 20
- 229920003023 plastic Polymers 0.000 claims description 11
- 239000004033 plastic Substances 0.000 claims description 11
- 230000002940 repellent Effects 0.000 claims description 7
- 239000005871 repellent Substances 0.000 claims description 7
- 229910010293 ceramic material Inorganic materials 0.000 claims 3
- 229920006334 epoxy coating Polymers 0.000 description 15
- 238000012545 processing Methods 0.000 description 15
- 239000000976 ink Substances 0.000 description 14
- 238000005530 etching Methods 0.000 description 10
- 238000004519 manufacturing process Methods 0.000 description 8
- 239000000523 sample Substances 0.000 description 8
- 239000004593 Epoxy Substances 0.000 description 7
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 7
- 239000000853 adhesive Substances 0.000 description 7
- 230000001070 adhesive effect Effects 0.000 description 7
- 230000004888 barrier function Effects 0.000 description 7
- 239000012472 biological sample Substances 0.000 description 7
- 238000001531 micro-dissection Methods 0.000 description 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
- 239000000049 pigment Substances 0.000 description 6
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 5
- 230000004913 activation Effects 0.000 description 5
- 230000008859 change Effects 0.000 description 5
- 239000003153 chemical reaction reagent Substances 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 238000001001 laser micro-dissection Methods 0.000 description 5
- 239000003921 oil Substances 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 4
- 241001510071 Pyrrhocoridae Species 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 229910002092 carbon dioxide Inorganic materials 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 238000010329 laser etching Methods 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- -1 siloxanes Chemical class 0.000 description 4
- 238000010186 staining Methods 0.000 description 4
- 238000012800 visualization Methods 0.000 description 4
- 239000000654 additive Substances 0.000 description 3
- 150000001298 alcohols Chemical class 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 238000009500 colour coating Methods 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 239000000975 dye Substances 0.000 description 3
- 230000005670 electromagnetic radiation Effects 0.000 description 3
- 238000010330 laser marking Methods 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 238000007639 printing Methods 0.000 description 3
- 239000004065 semiconductor Substances 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- 239000004408 titanium dioxide Substances 0.000 description 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 2
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 230000001464 adherent effect Effects 0.000 description 2
- 239000006229 carbon black Substances 0.000 description 2
- 239000000919 ceramic Substances 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 239000003599 detergent Substances 0.000 description 2
- 229920002313 fluoropolymer Polymers 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 238000002372 labelling Methods 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 239000002480 mineral oil Substances 0.000 description 2
- 239000012454 non-polar solvent Substances 0.000 description 2
- 239000000346 nonvolatile oil Substances 0.000 description 2
- 230000002186 photoactivation Effects 0.000 description 2
- 239000002798 polar solvent Substances 0.000 description 2
- 229920000647 polyepoxide Polymers 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- 229920000136 polysorbate Polymers 0.000 description 2
- 230000001846 repelling effect Effects 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 150000004756 silanes Chemical class 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- 239000000341 volatile oil Substances 0.000 description 2
- 239000008096 xylene Substances 0.000 description 2
- FWBHETKCLVMNFS-UHFFFAOYSA-N 4',6-Diamino-2-phenylindol Chemical compound C1=CC(C(=N)N)=CC=C1C1=CC2=CC=C(C(N)=N)C=C2N1 FWBHETKCLVMNFS-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 229910052684 Cerium Inorganic materials 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 238000000018 DNA microarray Methods 0.000 description 1
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 description 1
- PLXBWHJQWKZRKG-UHFFFAOYSA-N Resazurin Chemical compound C1=CC(=O)C=C2OC3=CC(O)=CC=C3[N+]([O-])=C21 PLXBWHJQWKZRKG-UHFFFAOYSA-N 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 1
- 229920006397 acrylic thermoplastic Polymers 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 229910052787 antimony Inorganic materials 0.000 description 1
- WATWJIUSRGPENY-UHFFFAOYSA-N antimony atom Chemical compound [Sb] WATWJIUSRGPENY-UHFFFAOYSA-N 0.000 description 1
- 239000007900 aqueous suspension Substances 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- ZMIGMASIKSOYAM-UHFFFAOYSA-N cerium Chemical compound [Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce] ZMIGMASIKSOYAM-UHFFFAOYSA-N 0.000 description 1
- 229910017052 cobalt Inorganic materials 0.000 description 1
- 239000010941 cobalt Substances 0.000 description 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 239000006059 cover glass Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000002224 dissection Methods 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 125000003700 epoxy group Chemical group 0.000 description 1
- 239000003822 epoxy resin Substances 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 238000007667 floating Methods 0.000 description 1
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 1
- 239000004811 fluoropolymer Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 230000002055 immunohistochemical effect Effects 0.000 description 1
- 238000012744 immunostaining Methods 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 238000009533 lab test Methods 0.000 description 1
- 238000000608 laser ablation Methods 0.000 description 1
- 239000011133 lead Substances 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 239000006060 molten glass Substances 0.000 description 1
- 239000012120 mounting media Substances 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 230000008447 perception Effects 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000010408 sweeping Methods 0.000 description 1
- ISXSCDLOGDJUNJ-UHFFFAOYSA-N tert-butyl prop-2-enoate Chemical compound CC(C)(C)OC(=O)C=C ISXSCDLOGDJUNJ-UHFFFAOYSA-N 0.000 description 1
- MPLHNVLQVRSVEE-UHFFFAOYSA-N texas red Chemical compound [O-]S(=O)(=O)C1=CC(S(Cl)(=O)=O)=CC=C1C(C1=CC=2CCCN3CCCC(C=23)=C1O1)=C2C1=C(CCC1)C3=[N+]1CCCC3=C2 MPLHNVLQVRSVEE-UHFFFAOYSA-N 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
- ACOJCCLIDPZYJC-UHFFFAOYSA-M thiazole orange Chemical compound CC1=CC=C(S([O-])(=O)=O)C=C1.C1=CC=C2C(C=C3N(C4=CC=CC=C4S3)C)=CC=[N+](C)C2=C1 ACOJCCLIDPZYJC-UHFFFAOYSA-M 0.000 description 1
- 229910052718 tin Inorganic materials 0.000 description 1
- 239000011135 tin Substances 0.000 description 1
- 239000010936 titanium Substances 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- VXUYXOFXAQZZMF-UHFFFAOYSA-N titanium(IV) isopropoxide Chemical compound CC(C)O[Ti](OC(C)C)(OC(C)C)OC(C)C VXUYXOFXAQZZMF-UHFFFAOYSA-N 0.000 description 1
- 229910052720 vanadium Inorganic materials 0.000 description 1
- GPPXJZIENCGNKB-UHFFFAOYSA-N vanadium Chemical compound [V]#[V] GPPXJZIENCGNKB-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/54—Labware with identification means
- B01L3/545—Labware with identification means for laboratory containers
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D5/00—Coating compositions, e.g. paints, varnishes or lacquers, characterised by their physical nature or the effects produced; Filling pastes
- C09D5/32—Radiation-absorbing paints
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0822—Slides
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/508—Containers for the purpose of retaining a material to be analysed, e.g. test tubes rigid containers not provided for above
- B01L3/5082—Test tubes per se
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/54—Labware with identification means
- B01L3/545—Labware with identification means for laboratory containers
- B01L3/5453—Labware with identification means for laboratory containers for test tubes
Definitions
- a chemically resistant coating for providing indicia on a substrate such as an analytic plate, such as a microscope slide, wherein the coating used to make the indicia can still substantially repel aqueous, non-aqueous, hydrophobic, lipophobic, processing liquids, other liquids, and biological liquids, and wherein the coating can be etched or developed by various means to produce the indicia on the analytic plate thereon.
- Figure 4 is a side view of an analytic plate having a coating thereon in accordance with an alternate embodiment of the present invention.
- 2 slide below the etched opaque epoxy coating.
- the colored coating on the lower surface can be seen through the upper etched portion as a contrasting color to further enhance the visualization of the indicium resulting from the etched portion of the topside epoxy coating etched away.
- These slides are manufactured for example by Erie Scietific Company, Portsmouth NH, and sold under the trade name ColorMark®
- Such slides having epoxy opaque coatings are useful for routine processing when the coated surface is to be totally immersed in processing chemicals and staining baths.
- the slide is used in a horizontal position for application of aqueous and non-aqueous liquids or liquid samples, the liquid sample often simply flows over the opaque epoxy coatings thereby resulting in a loss of liquid and /or sample applied to the slide.
- Coatings in the slides shown in U.S. Patent Numbers 4,481 ,246 and 4,624,882 have a raised surface of 0.0003 inches to 0.0008 inches. These heights have a very limited mechanical liquid barrier effect and do not prevent movement of the liquid over the slide.
- a chemically resistant coating for providing indicia on a substrate such as an analytic plate, such as a microscope slide, wherein the coating used to make the indicia can still substantially repel aqueous, non-aqueous, hydrophobic, lipophobic, processing liquids, other liquids, and biological liquids, and wherein the coating can be etched or developed by various means to produce the indicia on the analytic plate thereon.
- Figure 1 is a side view of an analytic plate having a coating thereon in accordance with an embodiment of the present invention.
- Figure 2 is a side view of an analyitc plate having first and second coatings thereon in accordance with an alternate embodiment of the invention.
- Figure 3 is a side view of an analyitc plate having first and second coatings thereon in accordance with an alternate embodiment of the invention.
- Figure 4 is a side view of an analytic plate having a coating thereon in accordance with an alternate embodiment of the present invention.
- Figure 5 is a side view of an analyitc plate having first and second coatings thereon in accordance with an alternate embodiment of the invention.
- Figure 6 is a side view of an analyitc plate having first and second coatings thereon in accordance with an alternate embodiment of the invention.
- Figure 7 is a side view of an analyitc plate having first and second coatings thereon in accordance with an alternate embodiment of the invention.
- Figure 8 is a side view of an analyitc plate having first and second coatings thereon in accordance with an alternate embodiment of the invention.
- Figure 9 is a side view of an analytic plate having a first, second.and third coating thereon in accordance with an alternate embodiment of the invention.
- Figure 10 is a side view of an analytic plate having a first, second.and third coating thereon in accordance with an alternate embodiment of the invention.
- Figure 11 is a side view of an analytic plate having a coating thereon in accordance with an alternate embodiment of the present invention.
- Figure 12 is a side view of an analyitc plate having first and second coatings thereon in accordance with an alternate embodiment of the invention.
- Figure 16 is a side view of an analyitc plate having first and second coatings thereon in accordance with an alternate embodiment of the invention.
- Figure 17 is a side view of an analyitc plate having first and second coatings thereon in accordance with an alternate embodiment of the invention.
- Figure 18 is a side view of an analytic plate having a first, second.and third coating thereon in accordance with an alternate embodiment of the invention.
- Such coatings generally referred to herein as "hydrophobic coatings" and which have these liquid containment (repellant) properties may comprise Teflon®, silicones, silanes, siloxanes, fluorosilanes, fluoropolymers, liquid repellent polymers, and combinations thereof present in a laboratory solvent resistant coating base comprising epoxies, acrylics, fluropolymers, elasotmers, or other types of coating bases know in the art of coatings.
- Other coatings having such liquid containment (repellant) properties based inks or coatings that are either opaque (e.g., such as shown in U.S.
- Indicia can be unique or non-unique symbols, numbers, codes, pattern(s), bar codes, 2-D codes, lines, holographic image, iridescent image and any other visually readable and or machine readable symbols or characters known in the art.
- barcodes contemplated for use in the present invention include but are not limited to symbologies having square, rectangular, circular, or irregular shapes and more specifically may include symbologies known as EAN-13, EAN-8, EAN-128, UPC-A, UPC-E, Code 11 , Code 39, Code 93, Code 25, Code 128, Codabar, MSI, 5
- a laser instrument which can be used in laser marking the opaque epoxy coatings used in the present invention as used in the laboratory setting is the Thermo Fisher Scientific Laser MicroWriterTM (e.g., catalog number B35300014) commercially available from Thermo Fisher Scientific Corp., 81 Wyma ⁇ Street Waltham, MA 02454.
- Other commercial sources of laser instruments are known and contemplated for use herein such as instruments from Hamar Laser Instruments, Inc., 5 Ye Olde Road Danbury, CT 06810 USA, Evergreen Laser Corpration, 9G Commerce Circle, Durham, CT 06422., and Universal Laser Systems, Inc.16008 North 81st Street Scottsdale, Arizona 85260.
- the substrate contemplated herein can be test tubes, plastic or glass microscope slides, glass plates, glass cover slips, petri-dishes, plastic cover slips, cover glass, analytic plates, ceramic plates, micro-titer plates, biochips, vials, and any other biologically associated container or substrate for processing biological specimens that require uniquely and non-uniquely identifiable indicia thereon.
- the preferred way to produce indicia on the etchable opaque hydrophobic coating as contemplated herein is to remove only a portion of the opaque hydrophobic coating to expose the clear glass below.
- the partially removed areas of the opaque coating form an indicium which can be used to uniquely or non-uniquely identify the substrate.
- at least a portion of the opaque hydrophobic coating extends completely from one edge of the plate to an opposite edge thus forming a liquid border across a portion of the substrate.
- the opaque hydrophobic coating can be partially removed to form the indicium by instruments known in the art as mentioned previously.
- the preferred method is etching and/or laser ablation.
- the photosensitive layer (developable coating) and opaque hydrophobic coating or hydrophobic coating can be 1 x 10 '10 , 1 x lO "9 , 1 x 1O -8 , 1 x 10 '7 , 1 x 10 "6 , 1 x 10 "5 , 1 x 10 "4 , 1 x 10 "3 , 1 x 10 "2 inches in thickness, for example. These thicknesses can alternately represent both the opaque coating and the developable coating together, or individually.
- the analytic plates described herein would be advantageously used with automated immunohistochemical instruments such as the Ventana® Benchmark® LT and XT stainers, Biogenex® Optimax® stainer, and Dako® Autostainer for example. These stainers have a problem with keeping the processing liquids within a discrete area on the slide due to the "wicking effect" of the processing liquid chemicals.
- the Ventana instruments reduce this "wicking effect" by placing a raised hydrophobic bar code labeled sticker on one end of the microscope slide. The sticker produces a physical barrier to reduce the liquid from flowing over the slide. This technique is cumbersome, requiring the production of a bar code label as well as the attachment of it to the slide thus covering up the marking surface portion of the slide.
- the proprietary bar code for use on the commercially available instruments instead can be directly automatically etched into the opaque hydrophobic coating of the present invention by commercially available marking and etching instruments thus producing a ready to use permanently labeled slide having a liquid containment border thereon, usable on processing instruments, without the need for the application of a liquid border sticker or label.
- a further advantage of the analytic plates of the present invention when used with the Ventana® staining instruments is that the oil evaporation prevention layer which is generally used in that system, which is a mixture of an oil and a surfactant, is repelled by the hydrophobic coating on the slide of the present invention.
- the markable coating on the substrate is an opaque, transparent, translucent, or invisible developable coating which contains at least one photoactivable agent or pigment that can darken or become opaque, change color, develop, expose, change molecularly, fluoresce, or otherwise become visually different in contrast to the rest of the developable coating when activated by laser light or any other type of effective electromagnetic radiation.
- the developable coating is present on the substrate (e.g., microscope slide) but is opaque, transparent, translucent, or invisible.
- the areas of the developable coating which are contacted by the laser light are activated, developed, and or exposed and darken or become opaque, change color, or become contrastingly visible to the eye as noted above. Only the light activated areas of the developable coating are darkened, turned opaque, develop, or visually change in contrast in relationship to the non-activated or non-developed parts of the developable coating.
- the developable coating is also referred to as a "photoactive coating.” These types of light activated agents are commercially available as discussed previously. The photoactivation of the developable coating can be caused by methods mentioned above to activate the photoagent present.
- the opaque, transparent, translucent, and or invisible developable coatings of the present invention retain their 9 hydrophobic or liquid repellant properties even if the exposed or developed "dark areas" retain or don't retain their hydrophobic or liquid repellant properties after laser light development by or exposure to the activation light.
- the hydrophobic developable coating on the substrate comprises a heat activated agent for converting portions of the coating to a visually different color, intensity or contrast that can be activated or developed by a heat source.
- the hydrophobic coatings contemplated herein for producing indicia can be opaque, opaque with color, transparent, translucent, or invisible.
- the coatings can be treated by mechanical etching, laser etching, laser light, other types of electromagnetic radiation, and/or heat printing devices to render the coating with indicia (visible identification markings) for labeling of an analytic plate like a microscope slide or other substrate using in the laboratory sciences or technologies as discussed elsewhere herein.
- the indicia rendered herein can be black, colored, visible through the coating (e.g., etched), or even different shades of color in contrast to the basic coating whether the basic coating is transparent, translucent, opaque, transparent and colored, translucent and colored, or opaque and colored.
- the developable coating may be light blue (or other color) before activation, and after activation, the identification markings (indicia) become either black or a darker shade of blue (or darker other color), to become visibly distinct and thus readable by the naked eye or by a machine readable instrument.
- the etchable or developable coating can be opaque and colored.
- the etchable or developable coating may contain an ink with pigment, with or without texture additives.
- the developable coating may have other activators therein to change the visually perception by prior mentioned devices and methods, preferably including laser activated pigments, compounds, and elements like mercury, cobalt, iron, copper, nickel, lead, and vanadium. Automation is also contemplated for the etching, developing, or activation of indicia on or in the coating.
- These inks or coatings can be screen printed, roll coated, bar coated, spray coated, pad printed, or applied anyway known in the art of applying coatings to substrates made of glass, plastic, or ceramic.
- the coating can be cured by UV, heat, air, and other known ways of curing ink coatings.
- the present invention comprises a microscope slide having an upper surface and a lower surface.
- the upper surface is for the placement of a biological specimen.
- the upper surface preferably has a first transparent, translucent, or invisible hydrophobic for example as described in U.S. Patent Numbers 5,948,685, 6,372,507, and 6,818,451 (each of which is hereby expressly incorporated herein by reference).
- the first coating is normally located in a marginal (e.g. leftward) area of the slide.
- the upper surface can have other liquid containment borders present on its surface as 10 described in the above mention patents.
- the upper surface of this embodiment of the present invention does not have an opaque coating thereon.
- the lower surface of the slide comprises a second transparent, translucent, or invisible developable coating adherent to the glass surface directly underneath or adjacent the first coating on the upper surface of the slide, the first coating (on the upper surface) is of a size and area typical of a prior art epoxy coated marking area (e.g., about 2.5 cm X 2.5 cm), the lower surface also comprises an opaque third coating disposed over the transparent, translucent, or invisible coating on said lower surface.
- the transparent, translucent, or invisible second coating on the lower surface is a developable coating able to be developed or otherwise turn a contrasting color or black when exposed with a laser or other means as described elsewhere herein. Only the area the laser comes in contact with is developed producing a dark or otherwise contrasting color or blackened indicium.
- the opaque third layer disposed over the laser developed coating on the lower surface serves as a contrasting color to the developed layer when viewed through the upper surface of the slide.
- the opaque third coating on the lower surface can be of any type of the known prior art opaque epoxy coatings for example.
- the opaque third coating can be white or have any color know in the prior art epoxy coated microscope slides or other colors.
- the upper surface first coating can be transparent or translucent with color or invisible, as long as it is liquid repellant.
- the activatable layer on the lower surface is a developable coating as described above. This embodiment thus features a transparent, translucent, or invisible developable second coating overlaid with an opaque epoxy third coating or coating which is transparent or translucent with color.
- a portion of the upper surface of the substrate can be coated with a colored transparent developable coating that is developable by a laser or other means.
- a hydrophobic coating such as described in U.S. Patent Numbers 5,948,685, 6,372,507, or 6,818,451 can be placed as an overcoat directly on top of the colored transparent developable coating. The laser passes through the uppermost transparent hydrophobic coating and develops an indicium in the colored transparent developable coating underneath.
- a 11 standard microscope slide, analytic plate, glass cover slip, and plastic cover slip can be completely coated or at least partially coated on the lower surface with a transparent or invisible developable coating.
- these substrates are known herein as "plates".
- the lower surface of the "substrate” is completely or substantially coated from one end to the other with a transparent, translucent or invisible developable coating thereon.
- the present embodiment modifies this technique by marking or developing or pointing to the areas removed by the micro-dissections. Once the micro-dissections are complete, in the prior art, there is plain glass around the "dissected" specimen. However, with the present novel embodiment, the once plain glass is now developed, e.g., indicated by a visible color, and the user can thus see the specific area of dissection. The indicia thus marked could be seen with the naked eye and also easily identified under the microscope. [0049] Laser microdissection, laser capture microdisection (LCM), and laser microdissection and pressure catapulting (LMPC) are used in medical and research laboratories to collect specific biological specimens, specific types of tissue, and biological cells. These methods cut out or separate portions of biological specimens.
- LCM laser capture microdisection
- LMPC laser microdissection and pressure catapulting
- the laser used 12 can be a carbon dioxide laser having an intensity of less than about 50 millliwatts(mW) to about 100 watts and a pulse duration between less than 1 to 1000 milliseconds(mS).
- the laser can also be an AIGaAs laser diode.
- the developed area would completely and specifically identify the original locations of the "dissected portion(s)" prior to microdissection, therefore eliminating not knowing where the "dissected portion(s)" were located originally before microdissection.
- the entire lower and/or upper surfaces of a substrate such as a glass or plastic cover slip are coated with a transparent or invisible developable coating.
- the transparent or invisible developable layer can be developed to mark or indicate positions relating to the slide or the biological specimen.
- a person would mark the areas of interest with an ink pen, felt tip marker, or other ink devices. These prior are ink markings are exposed on the upper surface of the cover slip and can become removed with handling; the ink may become brittle, and or fade over time resulting in the loss of the markings.
- This embodiment can be used for example with the coverslip as disclosed in U.S. Published Application 20070092408 (expressly incorporated by reference herein), which has 13 unique and non-unique indicia thereon.
- the transparent developable coating could be on the lower surface of the cover slip, and a dry film adhesive applied over the developable coating.
- an indicium can now be marked or developed in the developable coating on the undersurface of the coverslip with a laser or other means.
- the indicia can be a line, number, pattern, drawing, dot, barcode, 2-D code, or machine readable symbol or character, for example which uniquely or non-uniquely identifies the microscope slide or biological specimen thereon.
- raw panes of glass from which coverslips are cut can be coated on one surface with the transparent or invisible developable coating of the present invention and then the dry film adhesive could be applied directly over the developable coating.
- Individual cover slips could then have their unique or non-unique indicia developed by a laser from the upper or lower surfaces of the panes of glass before each cover slip is separately cut from the glass pane.
- Mass production of individual cover slips with or without dry film adhesive present on one side could be produced with unique or non-unique indicia effectively and efficiently all on the raw panes of glass before production of each individual coverslip.
- the non- hydrophobic developable coating can be mixed with the opaque epoxy coatings such as known in the prior art or with a transparent or translucent colored coating and placed on the upper surface of a microscope slide.
- the developable coating could be mixed with the molten glass during production of the glass either before or during the floating process or production of the glass, wherein the entire microscope slide can be developed at any location thereon.
- the slide could have a contrasting color coating anywhere on the slide that is required to enhance visualization of the developed area, preferably on the lower surface.
- Toner particles known in the prior art, which are made from plastics and pigments, like styrene acrylate copolymer, iron oxide (CAS 1317-61-9), carbon black (CAS 1333-86-4), amorphous silica (CAS 7631-86-9), and titanium dioxide (CAS 13463-67-7) in various combinations and percentage amounts are given an electric charge so that the toner particles cling to the charge image on the photoconductor.
- This pattern of toner particles are then transferred to the coating on the microscope slide electrostaticly and are fused to the coating on the microscope slide with heat and pressure. This process is well known in the art of laser printers printing on paper.
- Figure 1 shows a coated analytic plate 10 which is constructed of a substrate 12 having an upper surface 14, a lower surface 16, a right end 18, and a left end 20, and an etchabte hydrophobic coating 22 disposed on the upper surface 14 of the substrate 12 near the left end 20 thereof.
- the etchable hydrophobic coating 22 has liquid repellent properties as described elsewhere herein and may be comprised for example of an opaque heat cured epoxy resin having liquid repellent constituents.
- Figure 2 shows a coated analytic plate 30 which is constructed of a substrate 32 having an upper surface 34, a lower surface 36, a right end 38, and a left end 40, and an etchable hydrophobic first coating 42 disposed on the upper surface 34 of the substrate 32 near the left end 40 thereof, and an opaque second coating 44 disposed on the lower surface 36 of the substrate 32 near the left end 40 thereof and beneath the first coating 42.
- First coating 42 is preferably construced of an etchable opaque material having hydrophobic properties, wherein when an indicium is etched in the first coating 42, the substrate 32 is revealed and the opaque second coating 44 is visible therethrough.
- Figure 3 shows a coated analytic plate 50 which is constructed of a substrate 52 having an upper surface 54, a lower surface 56, a right end 58, and a left end 60, and an etchable hydrophobic first coating 62 disposed on the upper surface 54 of the substrate 52 near the left end 60 thereof and a colored transparent or translucent second coating 64 disposed on the lower surface 56 of the substrate 52 near the left end 60 thereof and below the first coating 62.
- the analytic plate 50 is similar to analytic plate 30 except the second coating 64 is colored and transparent or translucent rather than opaque.
- Figure 4 shows a coated analytic plate 70 which is constructed of a substrate 72 having an upper surface 74, a lower surface 76, a right end 78, and a left end 80, and a hydrophobic developable coating 82 disposed on the upper surface 74 of the substrate 72 near the left end 80 thereof.
- the material from which the developable coating 82 is made is described above.
- Figure 7 shows a coated analytic plate 130 which is constructed of a substrate 132 having an upper surface 134, a lower surface 136, a right end 138, and a left end 140, and a developable first coating 142 disposed on the lower surface 136 of the substrate 132 near the left end 140 thereof, and an opaque second coating 144 disposed on the first coating 142 near the left end 140 of the substrate 132 and beneath the first coating 142.
- Figure 9 shows a coated analytic plate 170 which is constructed of a substrate 172 having an upper surface 174, a lower surface 176, a right end 178, and a left end 180, and a hydrophobic first coating 182 disposed on the upper surface 174 of the substrate 172 near the left end 180 thereof and a developable second coating 184 disposed on the lower surface 176 of the substrate 172 near the left end 180 thereof, and an opaque third coating 186 disposed underneath the second coating 184.
- Figure 11 shows a coated analytic plate 210 which is constructed of a substrate 212 having an upper surface 214, a lower surface 216, a right end 218, and a left end 220, and a coating 222 disposed on the upper surface 214 of the substrate 212 near the left end 220 thereof.
- the coating 222 may be opaque or transparent and developable and hydrophobic, or coating 222 may be opaque, hydrophobic and non-developable.
- the coating 222 alternatively may be opaque, developable or non-developable, and non- hydrophobic.
- Figure 12 shows a coated analytic plate 230 which is constructed of a substrate 232 having an upper surface 234, a lower surface 236, a right end 238, and a left end 240, and an etchable hydrophobic first coating 242 disposed on the upper surface 234 of the substrate 232 near the left end 240 thereof and a transparent developable second coating 244 disposed on the lower surface 236 of the substrate 232 substantially over the entire lower surface 236.
- First coating 242 may be an opaque non-hydrophobic coating.
- Figure 13 shows a coated analytic plate 250 which is constructed of a substrate 252 having an upper surface 254, a lower surface 256, a right end 258, and a left end 260, and a transparent developable coating 262 disposed on the lower surface 256 of the substrate 252 substantially over the entire lower surface 256.
- Substrate 252 preferably also has a marking surface on the upper surface 254 near the left end 260. When the substrate 252 is a coverslip it generally has no marking surface but preferably has an indicium which indicates which side of the substrate 252 has the developable coating 262.
- Figure 14 shows a coated analytic plate 270 which is constructed of a substrate 272 having an upper surface 274, a lower surface 276, a right end 278, and a left end 280, and a transparent developable coating 282 disposed on the upper surface 274 of the substrate 272 substantially over the entire upper surface 256 thereof.
- Substrate 272 preferably has a marking surface on the upper ssurface 274 near left end 280.
- Figure 15 shows an analytic plate system 290 which is constructed of a first substrate 292 having an upper surface 294, a lower surface 296, a right end 298, and a left end 300, and a second substrate 302 having an upper surface 304, a lower surface 306, a right end 308 and a left end 310.
- a transparent developable coating 312 is disposed between the lower surface 296 of first substrate 292 and the upper surface 304 of second substrate 302, wherein the first substrate 292, coating 312, and second substrate 302 are laminated together.
- Figure 16 shows a coated analytic plate 320 which is constructed of a substrate 322 having an upper surface 324, a lower surface 326, a right end 328, and a left end 330, and a transparent developable first coating 332 disposed over the lower surface 326 of the substrate 322 substantially over the intire lower surface 326 and a transparent adhesive 18 second coating 334 disposed on the first coating 332 generally substantially covering the entire first coating 332.
- Figure 17 shows a coated analytic plate 340 which is constructed of a substrate 342 having an upper surface 344, a lower surface 346, a right end 348, and a left end 350, and a transparent developable first coating 352 disposed substantially over the upper surface 344 of the substrate 342 and an adhesive second coating 354 disposed on the lower surface 346 of the substrate 342 disposed on the lower surface 346 of the substrate 342 over substantially the entire lower surface 346.
- the substrate 342 is preferably a coverslip.
- Figure 18 shows a coated analytic plate 360 which is constructed of a substrate 362 having an upper surface 364, a lower surface 366, a right end 368, and a left end 370, and a transparent developable first coating 372 disposed over substantially the entire upper surface 364 of the substrate 362 and a transparent developable second coating 374 disposed over substantially the entire lower surface 366 of the substrate 362, and an adhesive third coating 376 disposed over substantially the entire second coating 374.
- the substrate 362 is preferably a coverslip.
- Figure 20 shows a coated analytic plate 400 which is constructed of a substrate 402 having an upper surface 404, a lower surface 406, a right end 408, and a left end 410, and a first coating 412 disposed on the upper surface 404 of the substrate 402 near the left end 410 thereof and a transparent developable second coating 414 disposed on the lower surface 406 of the substrate 402 over substantially the entire lower surface 406.
- the first coating may comprise a hydrophobic material, an opaque material, an etchable opaque material or an opaque or colored developable material, any of which may be hydrophobic or non-hydrophobic.
- Figure 21 shows a coated analytic plate 420 which is constructed of a substrate 422 having an upper surface 424, a lower surface 426, a right end 428, and left end 430, and a transparent developable first coating 432 disposed on the upper surface of the substrate 422 over substantially the entire upper surface 424, and a second coating 434 disposed on the first coating 432 near the left end 430 of the substrate 422.
- the second coating 434 may comprise a hydrophobic material, an opaque material, an etchable opaque material, or an opaque or developable material, any of which may be hydrophobic or non- hydrophobic and may or may not be used for marking. 19
- Figure 22 shows a coated analytic plate 440 which is constructed of a substrate 442 having an upper surface 444, a lower surface 446, a right end 448, and a left end 450, and a hydrophobic developable first coating 452 disposed on the upper surface 444 of the substrate 442 near the left end 450 thereof and a second coating 454 disposed on the lower surface 446 of the substrate 442 near the left end 450 thereof, and beneath the first coating 452.
- the second coating may be an opaque, or colored transparent or translucent material.
- Figure 23 shows a coated analytic plate 460 which is constructed of a substrate 462 having an upper surface 464, a lower surface 466, a right end 468, and a left end 470, and a developable first coating 472 disposed on the upper surface 464 of the substrate 462 near the left end 470 thereof, and a hydrophobic second coating 474 disposed on the first coating 472 near the left end 470 of the substrate 462, and an opaque third coating 476 disposed on the lower surface 466 beneath the first coating 472 and second coating 474.
- Figure 24 shows a coated analytic plate 480 which is constructed of a substrate 482 having an upper surface 484, a lower surface 486, a right end 488, and a left end 490, and a developable first coating 492 disposed on the upper surface 484 of the substrate 482 near the left end 490 thereof, and a hydrophobic second coating 494 disposed on the first coating 492 near the left end 490 of the substrate 482 and a transparent or translucent colored third coating 496 disposed on the lower surface 486 and beneath the first coating 492 and second coating 494.
- Figure 25 shows an analytic plate 500 comprising a substrate 502 (e.g., a microscope slide) having an upper surface 504 and a markable end 506.
- the substrate 502 has a transparent developable coating thereon either on the upper surface 504 or the lower surface of the substrate 502, for example as shown in the analytic plates of Figures 12, 20 or 21.
- the substrate 502 has a biological sample 510 disposed on the upper surface 504 thereof and is covered by a plate 508 such as a cover slip.
- the user has marked a variety of indicia 512 in the transparent developable coating which is disposed on the substrate 502.
- the indicia 512 can be referred to later by the user or a technician to identify specific positions on the biological sample 510.
- the transparent developable coating could be on a surface of the plate 508, as shown for exampe in the embodiments of Figures 16-19.
- the indicia 512 may be dark, colored, fluorescent, or any other visible markings.
- Indicium 512a represents a location on the biological sample 510 which has been marked by marking a perimeter.
- Indicium 512b represents a location on the biological sample 510 which has been dissected away, the "box" portion of the developable coating under the sample having been completely blackened.
- Figure 26 shows an analytic plate 520 comprising a substrate 522 having an upper surface 524 and a markable coating 526 as described elsewhere herein.
- the 20 substrate 522 has a transparent developable coating thereon, on upper surface 524 or on a lower surface thereof.
- a photactivator is used to develop a grid of lines 528 in the developable coating, either before or after a biological sample 530 is applied to the substrate 522.
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Organic Chemistry (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Clinical Laboratory Science (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Sampling And Sample Adjustment (AREA)
- Microscoopes, Condenser (AREA)
- Printing Methods (AREA)
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002661490A CA2661490A1 (en) | 2006-08-25 | 2007-08-25 | Analytic plates with markable portions and methods of use |
AU2007287027A AU2007287027A1 (en) | 2006-08-25 | 2007-08-25 | Analytic plates with markable portions and methods of use |
EP07837343A EP2062045A4 (en) | 2006-08-25 | 2007-08-25 | Analytic plates with markable portions and methods of use |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US84040706P | 2006-08-25 | 2006-08-25 | |
US60/840,407 | 2006-08-25 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2008024496A2 true WO2008024496A2 (en) | 2008-02-28 |
WO2008024496A3 WO2008024496A3 (en) | 2008-08-28 |
Family
ID=39107451
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2007/018786 WO2008024496A2 (en) | 2006-08-25 | 2007-08-25 | Analytic plates with markable portions and methods of use |
Country Status (6)
Country | Link |
---|---|
US (6) | US20080056952A1 (en) |
EP (1) | EP2062045A4 (en) |
CN (1) | CN101529247A (en) |
AU (1) | AU2007287027A1 (en) |
CA (1) | CA2661490A1 (en) |
WO (1) | WO2008024496A2 (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010032045A1 (en) * | 2008-09-19 | 2010-03-25 | Raymond A Lamb Limited | Method of marking a laboratory slide |
EP2226671A1 (en) * | 2009-03-03 | 2010-09-08 | Switch bvba | Microscope slide with diode-laser markable region |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1748144A (en) * | 2002-12-23 | 2006-03-15 | 尤尼森斯繁殖技术公司 | Be used for non-invasive measurement mechanism and method to the individual metabolic rate of substantially spherical metabolizing particle |
US8789756B2 (en) * | 2006-02-25 | 2014-07-29 | Roche Diagnostics Operations, Inc. | Test element coding apparatuses, systems and methods |
EP2282210A1 (en) * | 2006-06-16 | 2011-02-09 | Unisense Fertilitech A/S | Embryo quality assessment based on blastomere division and movement |
ATE503000T1 (en) | 2007-06-29 | 2011-04-15 | Unisense Fertilitech As | DEVICE, SYSTEM AND METHOD FOR OBSERVING AND/OR CULTIVING MICROSCOPIC OBJECTS |
CN102083954B (en) * | 2008-07-05 | 2014-09-03 | 尤尼森斯繁殖技术公司 | One to one identification system |
US9280641B2 (en) | 2011-04-22 | 2016-03-08 | Vaporprint, Llc | Mechanism for remotely facilitating authorization and activation of laboratory print media labeling |
US8951614B2 (en) * | 2011-04-22 | 2015-02-10 | Vaporprint, Llc | Mechanism for coating laboratory media with photo-sensitive material |
US9126422B2 (en) | 2011-04-22 | 2015-09-08 | Vaporprint, Llc | Mechanism for labeling laboratory print media |
DE102012214664A1 (en) * | 2012-08-17 | 2014-02-20 | Leica Microsystems Cms Gmbh | Slides with reference points |
EP2823889B1 (en) * | 2013-07-10 | 2016-10-19 | Roche Diagniostics GmbH | Device and method for biological sample collection and inspection |
CN105848917B (en) * | 2013-10-14 | 2019-12-06 | 康宁股份有限公司 | Method for printing decorative pattern on substrate |
EP2896458A1 (en) * | 2014-01-16 | 2015-07-22 | Euroimmun Medizinische Labordiagnostika AG | Transparent object holder with labelling |
DE102014202860B4 (en) * | 2014-02-17 | 2016-12-29 | Leica Microsystems Cms Gmbh | Providing sample information with a laser microdissection system |
GB2523774B (en) * | 2014-03-04 | 2019-07-17 | Calamat Ltd | Microscope slide |
US9370956B2 (en) * | 2014-05-02 | 2016-06-21 | The Johns Hopkins University | High resolution laser labeling of microscopic glass slides and histological sections |
WO2016044539A1 (en) * | 2014-09-18 | 2016-03-24 | Ortho-Clinical Diagnostics, Inc. | Fluorescent standard device and method of use |
WO2016123602A1 (en) * | 2015-01-31 | 2016-08-04 | Leica Biosystems Richmond, Inc. | Coating compositions and methods of making and using same |
US9796191B2 (en) | 2015-03-20 | 2017-10-24 | Corning Incorporated | Method of inkjet printing decorations on substrates |
DE102015108017A1 (en) * | 2015-05-20 | 2016-11-24 | Leica Microsystems Cms Gmbh | Method and examination system for examining and processing a microscopic sample |
EP3095517B1 (en) * | 2015-05-22 | 2020-01-08 | ibidi GmbH | Sample carrier with a reference structure and method for producing a sample carrier with a reference structure |
DE102017008619A1 (en) * | 2016-09-15 | 2018-03-15 | Asahi Glass Company, Limited | Method for producing a glass article and a glass article |
US11662564B2 (en) | 2017-06-15 | 2023-05-30 | Shenzhen Prs Limited | Paraffin shield coating for microscope slide |
WO2018228574A1 (en) * | 2017-06-15 | 2018-12-20 | Sunstone Scientific Limited. | Microscope slide with integrated black and white target |
EP3904112A1 (en) * | 2020-04-29 | 2021-11-03 | Fa-Tech Diagnostics Italia S.R.L. | Process for the inscription of glass microscope slides and glass microscope slides obtained thereby |
Family Cites Families (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3481659A (en) * | 1965-10-20 | 1969-12-02 | Harold James Rosenberg | Microscope slide |
US3482898A (en) * | 1967-02-06 | 1969-12-09 | Francois J G Van Den Bosch | Microscope system and reservoir for chemical preparations |
US3579540A (en) * | 1968-11-01 | 1971-05-18 | Howard G Ohlhausen | Method for protecting nonporous substrates and for rendering them water repellent |
US3736042A (en) * | 1971-05-05 | 1973-05-29 | Clinical Sciences Inc | Microscope slide assembly |
US3834823A (en) * | 1972-05-25 | 1974-09-10 | Gillette Co | Marking boards and erasable ink compositions therefor |
CA989652A (en) * | 1972-06-29 | 1976-05-25 | Gerhard Menzel | Glass slides with matted areas |
US3883398A (en) * | 1973-05-07 | 1975-05-13 | Bellco Glass Inc | Microculture slide chamber |
US3928142A (en) * | 1973-07-24 | 1975-12-23 | Dennis B Smith | Culture chamber for the study of biological systems and method of fabrication thereof |
US4017318A (en) * | 1976-01-02 | 1977-04-12 | Corning Glass Works | Photosensitive colored glasses |
US4516398A (en) * | 1980-10-08 | 1985-05-14 | Cooper Lasersonics, Inc. | Method of use of an ultrasonic surgical pre-aspirator having a orifice by-pass |
US4447140A (en) * | 1982-09-29 | 1984-05-08 | Campbell Jeptha E | Microscope slides |
US4481246A (en) * | 1982-11-15 | 1984-11-06 | Sybron Corporation | Microscope slide with raised marking surface |
US4624882A (en) * | 1982-11-15 | 1986-11-25 | Sybron Corporation | Microscope slide with raised marking surface |
DE3515160A1 (en) * | 1985-04-26 | 1986-11-06 | Klaus J. Dr.med. 7800 Freiburg Bross | METHOD FOR THE PRODUCTION OF SLIDES WITH DETERMINED REACTION FIELDS AND THE OBTAIN OBTAINED THEREFORE |
US4679914A (en) * | 1985-09-13 | 1987-07-14 | Erie Scientific Company | Microscope slide with top and bottom marking surfaces |
US4790640A (en) * | 1985-10-11 | 1988-12-13 | Nason Frederic L | Laboratory slide |
US5485527A (en) * | 1985-11-04 | 1996-01-16 | Becton Dickinson And Company | Apparatus and method for analyses of biological specimens |
US4725565A (en) * | 1986-06-26 | 1988-02-16 | Gte Laboratories Incorporated | Method of diffusing conductivity type imparting material into III-V compound semiconductor material |
US4867628A (en) * | 1988-01-15 | 1989-09-19 | Ammon J Preston | Dispenser storage system |
US4974952A (en) * | 1988-03-31 | 1990-12-04 | Focht Daniel C | Live cell chamber for microscopes |
DE3830721A1 (en) | 1988-09-09 | 1990-03-22 | Michael Dr Menton | Slide for use in laboratories, especially in medical laboratories |
CH677756A5 (en) * | 1989-01-26 | 1991-06-28 | Ciba Geigy Ag | |
US4967940A (en) * | 1989-02-21 | 1990-11-06 | Minnesota Mining And Manufacturing Co. | Method and apparatus for precision squeeze tube valving, pumping and dispensing of work fluid(s) |
EP0391848B1 (en) * | 1989-04-06 | 1993-09-01 | Ciba-Geigy Ag | Laser lettering of ceramic materials, glazes, glass ceramics and glasses |
US5111344A (en) * | 1989-06-16 | 1992-05-05 | Chase Instruments Corp. | Ceramic-coated microscope slide |
US5089315A (en) * | 1989-10-03 | 1992-02-18 | Erie Scientific Company | Glass slide |
US5061341A (en) * | 1990-01-25 | 1991-10-29 | Eastman Kodak Company | Laser-ablating a marking in a coating on plastic articles |
EP0478753B1 (en) * | 1990-04-06 | 1997-07-02 | The Perkin-Elmer Corporation | Automated molecular biology laboratory |
US5192503A (en) * | 1990-05-23 | 1993-03-09 | Mcgrath Charles M | Probe clip in situ assay apparatus |
JP2677734B2 (en) * | 1992-03-25 | 1997-11-17 | 三菱鉛筆株式会社 | Aqueous ballpoint pen ink volatilization prevention composition |
JPH0662958U (en) | 1993-02-12 | 1994-09-06 | 秋男 安藤 | Three-dimensional vacuum cleaner |
US5571721A (en) * | 1994-05-05 | 1996-11-05 | Erie Scientific Company | Improved biological culture slide and method of making same |
US5598295A (en) * | 1995-07-21 | 1997-01-28 | Erie Scientific Company | Microscope slide with contrasting surfaces on opposite sides |
US5838361A (en) * | 1996-01-11 | 1998-11-17 | Micron Technology, Inc. | Laser marking techniques |
EP0788745A1 (en) * | 1996-02-09 | 1997-08-13 | Societe Des Produits Nestle S.A. | Ice crystal growth inhibitor |
US5683786A (en) * | 1996-04-25 | 1997-11-04 | Health Card Technologies, Inc. | Microscope slide having bar code indicia inscribed thereon |
JPH09320952A (en) * | 1996-05-29 | 1997-12-12 | Nikon Corp | Aligner |
US6745067B1 (en) * | 1998-09-14 | 2004-06-01 | Lucid, Inc. | System for marking the locations of imaged tissue with respect to the surface of the tissue |
US5853894A (en) * | 1997-02-03 | 1998-12-29 | Cytonix Corporation | Laboratory vessel having hydrophobic coating and process for manufacturing same |
US6143496A (en) * | 1997-04-17 | 2000-11-07 | Cytonix Corporation | Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly |
JP3334611B2 (en) * | 1997-06-24 | 2002-10-15 | 日本板硝子株式会社 | Method for producing water-repellent article, water-repellent article and solution for forming water-repellent coating |
US5989692A (en) * | 1997-09-02 | 1999-11-23 | Cytonix Corporation | Porous surface for laboratory apparatus and laboratory apparatus having said surface |
US6075223A (en) * | 1997-09-08 | 2000-06-13 | Thermark, Llc | High contrast surface marking |
DE19742775B4 (en) | 1997-09-27 | 2005-03-17 | Wolfhard Zittwitz | entrapment |
US6037168A (en) * | 1997-12-31 | 2000-03-14 | Cytonix Corporation | Microbiological assembly comprising resealable closure means |
US6181811B1 (en) * | 1998-01-13 | 2001-01-30 | Neopath, Inc. | Method and apparatus for optimizing biological and cytological specimen screening and diagnosis |
US6818451B2 (en) * | 1998-02-10 | 2004-11-16 | Lee H. Angros | Analytic plate with containment border |
US5948685A (en) * | 1998-02-10 | 1999-09-07 | Angros; Lee | Analytic plate with containment border and method of use |
US6713304B2 (en) * | 1998-02-10 | 2004-03-30 | Lee H. Angros | Method of forming a containment border on an analytic plate |
US6723290B1 (en) * | 1998-03-07 | 2004-04-20 | Levine Robert A | Container for holding biologic fluid for analysis |
US6327507B1 (en) * | 1999-04-13 | 2001-12-04 | Glenn M. Buchan | Multiple extendable leadwire device |
US7011940B1 (en) * | 1999-04-14 | 2006-03-14 | Medical Discovery Partners Llc | Quality control for cytochemical assays |
US6759011B1 (en) * | 1999-11-22 | 2004-07-06 | Ventana Medical Systems, Inc. | Stackable non-stick coverslip |
US6615763B2 (en) * | 2000-05-12 | 2003-09-09 | Innovative Science Limited | Printing on microscope slides and histology cassettes |
DE10048376C2 (en) * | 2000-09-29 | 2002-09-19 | Fraunhofer Ges Forschung | Micro valve with a normally closed state |
US7118908B2 (en) * | 2000-10-25 | 2006-10-10 | Bor-Iuan Jan | On-spot selectively activated hydrophobic slide and preparation thereof |
US6673315B2 (en) * | 2001-06-29 | 2004-01-06 | Biomachines, Inc. | Method and apparatus for accessing a site on a biological substrate |
AU2003219936A1 (en) * | 2002-03-01 | 2003-09-16 | Markem Corporation | Marking substrates |
JP3991853B2 (en) * | 2002-09-12 | 2007-10-17 | セイコーエプソン株式会社 | ink cartridge |
KR101041970B1 (en) | 2004-06-11 | 2011-06-16 | 삼성전자주식회사 | Liquid crystal display device |
BRPI0617836A2 (en) * | 2005-10-26 | 2011-08-09 | Lee H Angros | microscope slide cover plate, microscope slide cover plate set, and method of forming a microscope slide cover plate set |
US7595874B1 (en) * | 2006-02-08 | 2009-09-29 | Sciperio, Inc. | Method of condensed cell slide preparation and detection of rarely occurring cells on microscope slides |
US20070187251A1 (en) * | 2006-02-14 | 2007-08-16 | Anthony Ward | Variable geometry electrophoresis chips, modules and systems |
-
2007
- 2007-08-24 US US11/895,544 patent/US20080056952A1/en not_active Abandoned
- 2007-08-25 WO PCT/US2007/018786 patent/WO2008024496A2/en active Application Filing
- 2007-08-25 US US11/895,501 patent/US20080056951A1/en not_active Abandoned
- 2007-08-25 CN CNA2007800399147A patent/CN101529247A/en active Pending
- 2007-08-25 EP EP07837343A patent/EP2062045A4/en not_active Withdrawn
- 2007-08-25 CA CA002661490A patent/CA2661490A1/en not_active Abandoned
- 2007-08-25 AU AU2007287027A patent/AU2007287027A1/en not_active Abandoned
-
2009
- 2009-07-29 US US12/511,754 patent/US20090291195A1/en not_active Abandoned
-
2014
- 2014-11-05 US US14/533,953 patent/US20150064712A1/en not_active Abandoned
-
2019
- 2019-11-19 US US16/688,807 patent/US11333587B2/en active Active
-
2022
- 2022-05-16 US US17/663,535 patent/US20220276138A1/en active Pending
Non-Patent Citations (1)
Title |
---|
See references of EP2062045A4 * |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2010032045A1 (en) * | 2008-09-19 | 2010-03-25 | Raymond A Lamb Limited | Method of marking a laboratory slide |
AU2009294400B2 (en) * | 2008-09-19 | 2014-02-06 | Shandon Diagnostics Limited | Method of marking a laboratory slide |
US8780150B2 (en) | 2008-09-19 | 2014-07-15 | Thomas Fergus Hughes | Method of making a laboratory slide |
EP2226671A1 (en) * | 2009-03-03 | 2010-09-08 | Switch bvba | Microscope slide with diode-laser markable region |
Also Published As
Publication number | Publication date |
---|---|
WO2008024496A3 (en) | 2008-08-28 |
US20080056951A1 (en) | 2008-03-06 |
US20220276138A1 (en) | 2022-09-01 |
US11333587B2 (en) | 2022-05-17 |
US20080056952A1 (en) | 2008-03-06 |
CA2661490A1 (en) | 2008-02-28 |
EP2062045A4 (en) | 2010-05-05 |
US20200088613A1 (en) | 2020-03-19 |
AU2007287027A1 (en) | 2008-02-28 |
EP2062045A2 (en) | 2009-05-27 |
US20090291195A1 (en) | 2009-11-26 |
US20150064712A1 (en) | 2015-03-05 |
CN101529247A (en) | 2009-09-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US11333587B2 (en) | Analytic plates with markable portions and methods of use | |
EP1055123B1 (en) | Analytic plate and method | |
CA2626459C (en) | Microscope coverslip and uses thereof | |
US9176029B2 (en) | Method of applying a biological specimen to an analytic plate | |
CN107597217A (en) | A kind of paper substrate micro-fluidic chip of result visualization and preparation method thereof | |
DK1803110T3 (en) | Tissue container and method for placing data on a tissue container | |
US6818451B2 (en) | Analytic plate with containment border | |
US6713304B2 (en) | Method of forming a containment border on an analytic plate | |
US20100110541A1 (en) | Microscope slide coverslip and uses thereof | |
US20100184629A1 (en) | Cell tray systems and methods | |
JP2002539478A (en) | Adhesive safety film as identification carrier | |
US6982828B2 (en) | Microscope slide having a marking region | |
US20140255274A1 (en) | Method of printing location markings on surfaces for microscopic research | |
US20230280579A1 (en) | Microscope slide | |
JP2022531956A (en) | Microfluidic arrays, manufacturing methods, measurement systems including microfluidic arrays, and use | |
GR1008931B (en) | Reference and callibration grid for improved real time detection of biological entities in microscopy diagnostic techniques |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WWE | Wipo information: entry into national phase |
Ref document number: 200780039914.7 Country of ref document: CN |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 07837343 Country of ref document: EP Kind code of ref document: A2 |
|
DPE2 | Request for preliminary examination filed before expiration of 19th month from priority date (pct application filed from 20040101) | ||
WWE | Wipo information: entry into national phase |
Ref document number: 2661490 Country of ref document: CA |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2007287027 Country of ref document: AU |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2007837343 Country of ref document: EP |
|
NENP | Non-entry into the national phase |
Ref country code: RU |
|
ENP | Entry into the national phase |
Ref document number: 2007287027 Country of ref document: AU Date of ref document: 20070825 Kind code of ref document: A |