WO2006034451A2 - Crystalline clopidogrel hydrobromide and processes for preparation thereof - Google Patents
Crystalline clopidogrel hydrobromide and processes for preparation thereof Download PDFInfo
- Publication number
- WO2006034451A2 WO2006034451A2 PCT/US2005/034149 US2005034149W WO2006034451A2 WO 2006034451 A2 WO2006034451 A2 WO 2006034451A2 US 2005034149 W US2005034149 W US 2005034149W WO 2006034451 A2 WO2006034451 A2 WO 2006034451A2
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- WIPO (PCT)
- Prior art keywords
- crystalline form
- powder
- ray diffraction
- diffraction pattern
- theta
- Prior art date
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- QKLHYWAZTQRTBR-RSAXXLAASA-N methyl (2s)-2-(2-chlorophenyl)-2-(6,7-dihydro-4h-thieno[3,2-c]pyridin-5-yl)acetate;hydrobromide Chemical compound Br.C1([C@H](N2CC=3C=CSC=3CC2)C(=O)OC)=CC=CC=C1Cl QKLHYWAZTQRTBR-RSAXXLAASA-N 0.000 title claims abstract description 139
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- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
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- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
Description
Claims
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05798184A EP1704152A2 (en) | 2004-09-21 | 2005-09-21 | Crystalline clopidogrel hydrobromide and processes for preparation thereof |
JP2006541522A JP2007513889A (en) | 2004-09-21 | 2005-09-21 | Crystalline clopidogrel bromide and process for its preparation |
IL181867A IL181867A0 (en) | 2004-09-21 | 2007-03-12 | Crystalline clopidogrel hydrobromide and processes for preparation thereof |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US61199504P | 2004-09-21 | 2004-09-21 | |
US60/611,995 | 2004-09-21 | ||
US61577104P | 2004-10-04 | 2004-10-04 | |
US60/615,771 | 2004-10-04 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006034451A2 true WO2006034451A2 (en) | 2006-03-30 |
WO2006034451A3 WO2006034451A3 (en) | 2006-08-10 |
Family
ID=35500763
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2005/034149 WO2006034451A2 (en) | 2004-09-21 | 2005-09-21 | Crystalline clopidogrel hydrobromide and processes for preparation thereof |
Country Status (6)
Country | Link |
---|---|
US (4) | US20060154957A1 (en) |
EP (1) | EP1704152A2 (en) |
JP (1) | JP2007513889A (en) |
KR (1) | KR20070052780A (en) |
IL (1) | IL181867A0 (en) |
WO (1) | WO2006034451A2 (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1970054A2 (en) | 2007-03-14 | 2008-09-17 | Ranbaxy Laboratories Limited | Clopidogrel tablets |
EP2107061A1 (en) | 2008-04-02 | 2009-10-07 | Krka Tovarna Zdravil, D.D., Novo Mesto | Process for the preparation of optically enriched clopidogrel |
CN101427992B (en) * | 2007-11-07 | 2011-02-09 | 浙江华海药业股份有限公司 | Clopidogrel hydrobromate preparation and method of producing the same |
EP3287447A1 (en) | 2010-07-23 | 2018-02-28 | Grünenthal GmbH | Salts or co-crystals of 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol |
US11065237B2 (en) | 2013-11-15 | 2021-07-20 | Akebia Therapeutics, Inc. | Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid, compositions, and uses thereof |
Families Citing this family (9)
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KR100692934B1 (en) * | 2000-12-25 | 2007-03-12 | 상꾜 가부시키가이샤 | Medicinal compositions containing aspirin |
WO2005063708A2 (en) * | 2003-11-03 | 2005-07-14 | Cadila Healthcare Limited | Processes for preparing different forms of (s)-(+)- clopidogrel bisulfate |
WO2006034451A2 (en) * | 2004-09-21 | 2006-03-30 | Teva Pharmaceutical Industries Ltd. | Crystalline clopidogrel hydrobromide and processes for preparation thereof |
CA2594763A1 (en) * | 2005-02-24 | 2006-08-31 | Teva Pharmaceutical Industries Ltd. | Clopidogrel base suitable for pharmaceutical formulation and preparation thereof |
WO2008019053A2 (en) * | 2006-08-03 | 2008-02-14 | Teva Pharmaceutical Industries Ltd. | Process for preparing clopidogrel bisulphate |
DK2152078T3 (en) | 2007-04-27 | 2021-02-08 | Cydex Pharmaceuticals Inc | FORMULATIONS CONTAINING CLOPIDOGREL AND SULFOALKYLETHERCYCLODEXTRINE AND USE PROCEDURES |
DK3100728T3 (en) | 2009-05-13 | 2020-02-17 | Cydex Pharmaceuticals Inc | PHARMACEUTICAL COMPOSITIONS COMPREHENSIVE PRASUGREL AND CYCLODEXTRIN DERIVATIVES AND METHODS FOR PREPARING AND USING SAME |
CN101766573B (en) | 2010-02-05 | 2013-02-13 | 上海安必生制药技术有限公司 | Preparation process of clopidogrel bisulfate solid preparation |
WO2012123958A1 (en) | 2011-02-14 | 2012-09-20 | Cadila Healthcare Limited | Highly pure salts of clopidogrel free of genotoxic impurities |
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US600875A (en) * | 1898-03-22 | Earth-auger | ||
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FR2530247B1 (en) * | 1982-07-13 | 1986-05-16 | Sanofi Sa | NOVEL THIENO (3, 2-C) PYRIDINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THERAPEUTIC APPLICATION |
FR2623810B2 (en) | 1987-02-17 | 1992-01-24 | Sanofi Sa | ALPHA SALTS- (TETRAHYDRO-4,5,6,7 THIENO (3,2-C) PYRIDYL-5) (2-CHLORO-PHENYL) -THETHYL ACETATE DEXTROGYRE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME |
FR2652575B1 (en) * | 1989-09-29 | 1992-01-24 | Sanofi Sa | PROCESS FOR THE PREPARATION OF ALPHA-BROMO PHENYLACETIC ACIDS. |
FR2664276B1 (en) * | 1990-07-04 | 1992-10-23 | Sanofi Sa | GLYCIDIC THIENYL-2 DERIVATIVE, ITS PREPARATION METHOD AND ITS USE AS A SYNTHESIS INTERMEDIATE. |
US5576328A (en) * | 1994-01-31 | 1996-11-19 | Elf Sanofi | Method for the secondary prevention of ischemic events |
FR2760456B1 (en) * | 1997-03-05 | 2000-05-12 | Sanofi Sa | PROCESS FOR THE PREPARATION OF 2-THIENYL-ETHYLAMINE DERIVATIVES |
HU225503B1 (en) * | 1997-05-13 | 2007-01-29 | Sanofi Aventis | Novel 2-(2-halophenyl)-2-(2-(2-thienyl)-ethylamino)-acetamides and process for producing them |
HU225504B1 (en) * | 1997-05-13 | 2007-01-29 | Sanofi Aventis | Novel halophenyl-(2-(2-thienyl)-ethylamino)-acetonitriles and process for producing them |
HU222283B1 (en) * | 1997-05-13 | 2003-05-28 | Sanofi-Synthelabo | Novel process for producing thieno[3,2-c]pyridine derivatives |
FR2779726B1 (en) * | 1998-06-15 | 2001-05-18 | Sanofi Sa | POLYMORPHIC FORM OF CLOPIDOGREL HYDROGENOSULFATE |
US6767913B2 (en) * | 2001-12-18 | 2004-07-27 | Teva Pharmaceutical Industries Ltd. | Crystal forms iii, iv, v, and novel amorphous form of clopidogrel hydrogensulfate, processes for their preparation, processes for the preparation of form i, compositions containing the new forms and methods of administering the new forms |
US7074928B2 (en) * | 2002-01-11 | 2006-07-11 | Teva Pharmaceutical Industries, Ltd. | Polymorphs of clopidogrel hydrogensulfate |
US6800759B2 (en) * | 2002-08-02 | 2004-10-05 | Teva Pharmaceutical Industries Ltd. | Racemization and enantiomer separation of clopidogrel |
IL166593A0 (en) * | 2002-08-02 | 2006-01-15 | Racemization and enantiomer separation of clopidogrel | |
US20060258677A1 (en) * | 2003-02-15 | 2006-11-16 | Teva Pharmaceutical Industries Ltd. | Novel crystalline forms of gatifloxacin and processes for preparation |
GB0321256D0 (en) | 2003-09-11 | 2003-10-08 | Generics Uk Ltd | Novel crystalline compounds |
KR20070012675A (en) * | 2004-04-20 | 2007-01-26 | 사노피-아벤티스 | Polymorphic forms of methyl (+)-(s)-alpha-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4h) acetate hydrobromide, clopidogrel hydrobromide |
WO2006034451A2 (en) * | 2004-09-21 | 2006-03-30 | Teva Pharmaceutical Industries Ltd. | Crystalline clopidogrel hydrobromide and processes for preparation thereof |
CA2594763A1 (en) * | 2005-02-24 | 2006-08-31 | Teva Pharmaceutical Industries Ltd. | Clopidogrel base suitable for pharmaceutical formulation and preparation thereof |
-
2005
- 2005-09-21 WO PCT/US2005/034149 patent/WO2006034451A2/en active Application Filing
- 2005-09-21 JP JP2006541522A patent/JP2007513889A/en active Pending
- 2005-09-21 KR KR1020077005407A patent/KR20070052780A/en not_active Application Discontinuation
- 2005-09-21 EP EP05798184A patent/EP1704152A2/en not_active Withdrawn
- 2005-09-21 US US11/233,491 patent/US20060154957A1/en not_active Abandoned
-
2007
- 2007-03-12 IL IL181867A patent/IL181867A0/en unknown
-
2008
- 2008-07-31 US US12/221,257 patent/US20090187022A1/en not_active Abandoned
- 2008-07-31 US US12/221,350 patent/US20080306268A1/en not_active Abandoned
- 2008-07-31 US US12/221,349 patent/US20080300409A1/en not_active Abandoned
Non-Patent Citations (1)
Title |
---|
See references of EP1704152A2 * |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1970054A2 (en) | 2007-03-14 | 2008-09-17 | Ranbaxy Laboratories Limited | Clopidogrel tablets |
CN101427992B (en) * | 2007-11-07 | 2011-02-09 | 浙江华海药业股份有限公司 | Clopidogrel hydrobromate preparation and method of producing the same |
EP2107061A1 (en) | 2008-04-02 | 2009-10-07 | Krka Tovarna Zdravil, D.D., Novo Mesto | Process for the preparation of optically enriched clopidogrel |
EP3287447A1 (en) | 2010-07-23 | 2018-02-28 | Grünenthal GmbH | Salts or co-crystals of 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol |
US11065237B2 (en) | 2013-11-15 | 2021-07-20 | Akebia Therapeutics, Inc. | Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid, compositions, and uses thereof |
US11690836B2 (en) | 2013-11-15 | 2023-07-04 | Akebia Therapeutics, Inc. | Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid, compositions, and uses thereof |
Also Published As
Publication number | Publication date |
---|---|
JP2007513889A (en) | 2007-05-31 |
WO2006034451A3 (en) | 2006-08-10 |
US20080306268A1 (en) | 2008-12-11 |
KR20070052780A (en) | 2007-05-22 |
US20060154957A1 (en) | 2006-07-13 |
US20080300409A1 (en) | 2008-12-04 |
IL181867A0 (en) | 2007-07-04 |
EP1704152A2 (en) | 2006-09-27 |
US20090187022A1 (en) | 2009-07-23 |
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