WO2004018465A2 - Benzonaphthyridines with pde 3/4 inhibiting activity - Google Patents
Benzonaphthyridines with pde 3/4 inhibiting activity Download PDFInfo
- Publication number
- WO2004018465A2 WO2004018465A2 PCT/EP2003/008996 EP0308996W WO2004018465A2 WO 2004018465 A2 WO2004018465 A2 WO 2004018465A2 EP 0308996 W EP0308996 W EP 0308996W WO 2004018465 A2 WO2004018465 A2 WO 2004018465A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- alkyl
- alkoxy
- methyl
- phenyl
- hydrogen
- Prior art date
Links
- 0 CN(C)C(N(C)*)=N* Chemical compound CN(C)C(N(C)*)=N* 0.000 description 4
- PFRCKDKKJIACLS-UHFFFAOYSA-N CC(C)NC(N(CC1)CCN1c1ccccc1)=N Chemical compound CC(C)NC(N(CC1)CCN1c1ccccc1)=N PFRCKDKKJIACLS-UHFFFAOYSA-N 0.000 description 1
- LBKPZDZOFSIILH-UHFFFAOYSA-N CC(C)NC(N1CCSCC1)=N Chemical compound CC(C)NC(N1CCSCC1)=N LBKPZDZOFSIILH-UHFFFAOYSA-N 0.000 description 1
- SRUGWSFEPMKUAK-UHFFFAOYSA-N CC(C)NC(NC#N)=N Chemical compound CC(C)NC(NC#N)=N SRUGWSFEPMKUAK-UHFFFAOYSA-N 0.000 description 1
- JIHRXHYFBFKBMP-UHFFFAOYSA-N CC(C)NC(NCCN1CCOCC1)=N Chemical compound CC(C)NC(NCCN1CCOCC1)=N JIHRXHYFBFKBMP-UHFFFAOYSA-N 0.000 description 1
- OBQZAOXHLNJPOJ-UHFFFAOYSA-N CNC(N(CC1)CCN1c1cccc(C(F)(F)F)c1)=N Chemical compound CNC(N(CC1)CCN1c1cccc(C(F)(F)F)c1)=N OBQZAOXHLNJPOJ-UHFFFAOYSA-N 0.000 description 1
- ICBRRUHLIDWEOP-UHFFFAOYSA-N N=C(NC(I)I)Nc1ccccc1 Chemical compound N=C(NC(I)I)Nc1ccccc1 ICBRRUHLIDWEOP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Definitions
- the invention relates to novel 6-phenylbenzonaphthyridines which are used in the pharmaceutical industry for the production of pharmaceutical compositions.
- the invention thus relates to compounds of formula 1 ,
- R1 is 1-4C-alkyl
- R2 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy, or 1-4C-alkoxy which is completely or predominantly substituted by fluorine
- R3 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy, or 1-4C-alkoxy which is completely or predominantly substituted by fluorine, or in which
- R2 and R3 together are a 1-2C-alkyIenedioxy group
- R4 is hydrogen, halogen, nitro, 1-4C-alkyl, trifluoromethyl or 1-4C-alkoxy
- R5 is a radical of the formulae (a), (b) or (c)
- R6, R7, R8 and R9 independently of one another are hydrogen, 1-7C-alkyl, 3-7C-cycloalkyl, 3-7C-cycloalkylmethyl, cyano, hydroxy-2-4C-alkyl, 1-4C-alkoxy-2-4C-alkyl or R26, with the proviso that at least one of R6, R7, R8 and R9 is 1-4C-alkoxy-2-4C-alkyl, or
- R6 is hydrogen, 1-7C-alkyl, 3-7C-cycloalkyl, 3-7C-cycloalkylmethyl, hydroxy-2-4C-alkyl, 1-4C- alkoxy-2-4C-alkyl or R26,
- R7 is hydrogen, 1-7C-alkyl, 3-7C-cycloalkyl, 3-7C-cycloalkylmethyl, hydroxy-2-4C-alkyl, 1-4C- aikoxy-2-4C-alkyl or R26, and
- R8 and R9 together and including the nitrogen atom to which both are bonded, are a piperazin-
- 1-yl radical substituted in 4-position by R17 a azocan-1-yl, azonan-1-yl, azecan-1-yl, tetrahydro- isoquinolin-2-yl, tetrahydro-6,7-dimethoxyisoquinolin-2-yl, 3,5-dimethyl-pyrazol-1-yl, pyrazol-1-yl,
- R6 is hydrogen, 1-7C-alkyl, 3-7C-cycloalkyl, 3-7C-cycloalkylmethyl, hydroxy-2-4C-alkyl, 1-4C- alkoxy-2-4C-alkyl or R26,
- R7 is hydrogen, 1-7C-alkyl, 3-7C-cycloalkyl, 3-7C-cycloalkylmethyl, hydroxy-2-4C-alkyl, 1-4C- alkoxy-2-4C-alkyl or R26,
- R8 is hydrogen, 1 ⁇ 7C-alkyl, 3-7C-cycloalkyl, 3-7C-cycloalkylmethyi; hydro ⁇ y-2-4C-alkyl, 1-4C- alkoxy-2-4C-alkyl or R26, arid R9 is cyano, Aryll, R26, naphthyl, phenyl, phenyl substituted by R18 and/or R19, phenyl-1-4C- alkyl or phenyl-1-4C-alkyl substituted in the phenyl moiety by R20 and/or R21 ,
- R10 and R11 independently of one another are hydrogen, 1-7C-alkyl, 3-7C-cycloalkyl, 3-7C-cy- cloalkylmethyl, hydroxy-2-4C-alkyl, 1-4C-alkoxy-2-4C-alkyl or R26, and
- R12 and R13 are a pipera- zin-1-yl radical substituted in 4-position by R17, a azocan-1-yl, azonan-1-yl, azecan-1-yl, tetrahy- droisoquinolin-2-yl, tetrahydro-6,7-dimethoxyisoquinolin-2-yl, 3,5-dimethyl-pyrazol-1-yl, pyrazol- 1-yl, 2,6-dimethyl-morpholin-4-yl, 2,6-dimethyl-piperidin-1-yl, 4-benzyl-piperidin-1-yl, thiomorpholin-4-yl or 1H-1,2,4-triazol-1-yl radical, or
- R10 and R11 together and including the nitrogen atom to which both are bonded, are a 2,6- dimethyl-morpholin-4-yl, 2,6-dimethyl-piperidin-1-yl, 4-benzyl-piperidin-1-yl or thiomorpholin-4-yl radical, and
- R12 and R13 together and including the nitrogen atom to which both are bonded, are a pyrroli- din-1-yl, piperidin-1-yl, hexahydroazepin-1-yl, morpholin-4-yl, 4-(1-4C-alkyl-)-piperazin-1-yl, 2,6-dimethyl-morpholin-4-yl, 2,6-dimethyl-piperidin-1-yl, 4-benzyl-piperidin-1-yl or thiomorpholin- 4-yl radical,
- R14 is hydrogen, 1-7C-alkyl, 3-7C-cycloalkyl, 3-7C-cycloalkylmethyl, hydroxy-2-4C-alkyl, 1-4C- alkoxy-2-4C-alkyl or R26, and
- Aryll is 4-methylthiazol-2-yl, benzimidazol-2-yl, 5-nitrobenzimidazol-2-yl, 5-chlorobenzimidazol-2-yl, 5-methylbenzimidazol-2-yl, 4-methylquinazolin-2-yl, benzothiazol-2-yl, benzoxazol-2-yl or pyrimi- din-2-yl,
- Aryl2 is 1-methyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl, imidazol-2-yl, 4,5-dicyano-imidazol-2-yl, 4-me- thyl-imidazol-2-yl, 4-ethyl-benzimidazol-2-yl, 4-acetyl-imidazol-2-yl, 1H-[1,2,4]triazol-3-yl, benz- imidazol-2-yl, 1-methyl-benzimidazol-2-yl, 1-ethyl-benzimidazol-2-yl, 5,6-dimethyl-benzimidazol- 2-yl, purin-8-yl, 6-amino-7-methyi-7H-purine-8-yl, 1 ,6-dimethylimidazo[4,5-b]pyridin-2-yl, 1 ,5,6- trimethylimidazo[4,5-b]pyridin-2-yl, 1
- R18 is halogen, nitro, carboxyl, 1-4C-alkyl, trifluoromethyl or 1-4C-alkoxy,
- R19 is halogen, 1-4C-alkyl or 1-4C-alkoxy
- R20 is halogen, nitro, carboxyl, 1-4C-alkyl, trifluoromethyl or 1-4C-alkoxy,
- R21 is halogen, 1-4C-alkyl or 1-4C-alkoxy
- R22 is halogen, nitro, carboxyl, 1-4C-alkyl, 1-4C-alkylcarbonyl, trifluoromethyl or 1-4C-alkoxy,
- R23 is halogen, 1-4C-alkyl or 1-4C-alkoxy
- R24 is halogen, nitro, carboxyl, 1-4C-alkyl, trifluoromethyl or 1-4C-alkoxy,
- R25 is halogen, 1-4C-alkyl or 1-4C-alkoxy
- R26 is R27(R28)N-2-4C-alkyl wherein
- R27 and R28 together and including the nitrogen atom to which both are bonded, are a pyrrolidin-1-yl, piperidin-1-yl, piperazin-1-yl, 4-(1-4C-alkyl-)piperazin-1-yl, azepan-1yl, azocan-1-yl, azonan-1-yl, azecan-1-yl, tetrahydroisoquinolin-2-yI, tetrahydro-6,7-dimethoxyisoquinolin-2-yl, 3,5-dimethyl- pyrazol-1-yl, pyrazol-1-yl, morpholin-4-yl, 2,6-dimethyl-morpholin-4-yl, 2,6-dimethyl-piperidin-1-yl, 4-benzyl-piperidin-1-yl, thiomorpholin-4-yl or 1 H-1,2,4-triazoI-1-yl radical, the salts of these compounds, as well as the N-oxid
- 1-4C-Alkyl represents a straight-chain or branched alkyl radical having 1 to 4 carbon atoms. Examples which may be mentioned are the butyl, isobutyl, sec-butyl, tert-butyl, propyl, isopropyl and, preferably, the ethyl and methyl radicals.
- 2-4C-Alkyl represents a straight-chain or branched alkyl radical having 2 to 4 carbon atoms. Examples which may be mentioned are the butyl, isobutyl, sec-butyl, tert-butyl, propyl, isopropyl and, preferably, the ethyl radicals.
- 1-4C-Alkoxy represents radicals which, in addition to the oxygen atom, contain a straight-chain or branched alkyl radical having 1 to 4 carbon atoms. Examples which may be mentioned are the butoxy, isobutoxy, sec-butoxy, tert-butoxy, propoxy, isopropoxy and, preferably, the ethoxy and methoxy radicals.
- 3-7C-Cycloalkoxy represents, for example, cyclopropyloxy, cyclobutyloxy, cyclopentyloxy, cyclohexyloxy and cycloheptyloxy, of which cyclopropyloxy, cyclobutyloxy and cyclopentyloxy are preferred.
- 3-7C-Cycloalkylmethoxy represents, for example, cyclopropylmethoxy, cyclobutylmethoxy, cyclopentyl- methoxy, cyclohexylmethoxy and cycloheptylmethoxy, of which cyclopropylmethoxy, cyclobutylmethoxy and cyclopentylmethoxy are preferred.
- the 2,2,3,3,3-pentafluoro- propoxy As 1-4C-Alkoxy which is completely or predominantly substituted by fluorine, the 2,2,3,3,3-pentafluoro- propoxy, the perfluoroethoxy, the 1,1 ,2,2-tetrafluoroethoxy, the 1 ,2,2-trifluoroethoxy, the trifluorometh- oxy, in particular the 2,2,2-trifluoroethoxy, and preferably the difluoromethoxy radicals, for example, may be mentioned.
- "predominantly" means that more than half of the hydrogen atoms of the 1-4C-alkoxy groups are replaced by fluorine atoms.
- 1-2C-Alkylenedioxy represents, for example, the methylenedioxy (-0-CH 2 -0-) or the ethylenedioxy (-0-CH 2 -CH 2 -0-) radical.
- 1-7C-Alkyl represents straight-chain or branched alkyl radicals having 1 to 7 carbon atoms. Examples which may be mentioned are the heptyl, isoheptyl (5-methylhexyl), hexyl, isohexyl (4-methylpentyl), neohexyl (3,3-dimethylbutyl), pentyl, isopentyl (3-methylbutyl), neopentyl (2,2-dimethyIpropyl), butyl, isobutyl, sec-butyl, tert-butyl, propyl, isopropyl, ethyl or methyl radical.
- 3-7C-Cycloalkyl represents the cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl or cycloheptyl radical.
- 3-7C-Cycloalkylmethyl represents a methyl radical which is substituted by one of the abovementioned 3-7C-cycloalkyl radicals.
- Examples which may be mentioned are the cycloalkylmethyl radicals cyclopro- pylmethyl, cyclobutylmethyl and cyclopentylmethyl.
- Hydroxy-2-4C-alkyl represent a 2-4C-a!kyl radical which is substituted by a hydroxyl group. Examples which may be mentioned are the 2-hydroxyethyl and the 3-hydroxy ropyl radicals.
- hydroxy-2-4C-alkoxy-2-4C-alkyl radical is the (2- hydroxyethoxy)ethyl radical.
- An example of a 1-4C-alkoxy-2-4C-alkoxy-2-4C-alkyl radical is the (2-methoxyethoxy)ethyl radical.
- Halogen within the meaning of the invention is fluorine, chlorine or bromine.
- 1-4C-Alkylcarbonyl is a carbonyl group to which one of the abovementioned 1-4C-alkyl radicals is bonded.
- An example is the acetyl radical [CH 3 C(0)-].
- 1-4C-Alkoxycarbonyl is a carbonyl group to which one of the abovementioned 1-4C-alkoxy radicals is bonded.
- examples are the methoxycarbonyl [CH 3 0-C(0)-] and the ethoxycarbonyl [CH 3 CH 2 0-C(0)-] radical.
- 1-4C-Alkoxycarbonyl-1-4C-alkyl stands for one of the abovementioned 1-4C-alkyl radicals, which is substituted by one of the abovementioned 1-4C-alkoxycarbonyl radicals.
- An example is the ethoxycarbonylmethyl radical [CH 3 CH 2 OC(0)CH2-].
- 1-4C-Alkoxy-2-4C-alkyl represents a 2-4C-alkyl radical, which is substituted by one of the abovementioned 1-4C-alkoxy radicals. Examples which may be mentioned are the methoxyethyl and the ethoxyethyl radical.
- Phenyl-1-4C-alkyl radicals stand for one of the abovementioned 1-4C-alkyl radicals substituted by an phenyl group. Examples which may be mentioned are the phenylethyl and the benzyl radical.
- R27(R28)N-2-4C-alkyl radicals stand for one of the above-mentioned 2-4C-alkyl radicals substituted by an R27(R28)N- group. Examples which may be mentioned are mo ⁇ holin-4-ylethyl and the thiomorpholin-4-ylethy! radicals.
- N-oxides of these compounds stands for any single or multiple N-oxide(s), which can be formed starting from the compounds of formula 1. Preferred are the single N-oxides at the nitrogen atom in 2-position of the benzonaphthyridine ring system.
- R5 is bonded to the carbonyl group in formula 1 via the bond that bears the horizontal dotted line.
- the additional dotted lines in formula (c) indicate that there can be in the indicated positions a single or a double bond.
- the substituents R4 and -C(0)R5 of the compounds of formula 1 can be attached in the ortho, meta or para position with respect to the binding position in which the 6-phenyl ring is bonded to the benzonaphthyridine ring system. Preference is given to compounds of formula 1, in which R4 is hydrogen and -C(0)R5 is attached in the meta or in the para position; most preferred is the para position.
- Suitable salts of compounds of formula 1 - depending on substitution - are all acid addition salts or all salts wit j bases.
- the pharmacologically tolerable salts of the inorganic and organic acids and bases customarily used, in pharmacy may be particularly mentioned.
- water-soluble and water-insoluble acid addition salts witlracids such as, for example, hydrochloric-acid, hydrobromic acid, phosphoric acid, nitric acid, sulfuric acid, acetic acid, citric acid, D-gluconic acid, benzoic acid, 2-(4-hydroxybenzoyl)benzoic acid, butyric acid, sulfosalicylic acid, maleic acid, lauric acid, malic acid, fumaric acid, succinic acid, oxalic acid, tartaric acid, embonic acid, stearic acid, toluene- sulfonic acid, methanesulfonic acid or 3-hydroxy-2-naphthoic acid, where the acids are employed in salt preparation - depending on whether a mono- or polybasic acid is concerned and depending on which salt is desired - in an equimolar quantitative ratio or one differing therefrom.
- salts with bases are also suitable.
- examples of salts with bases which may be mentioned are alkali metal (lithium, sodium, potassium) or calcium, aluminum, magnesium or titanium salts, where here too the bases are employed in salt preparation in an equimolar quantitative ratio or one differing therefrom.
- Pharmacologically intolerable salts which can be obtained first, for example, as process products in the preparation of the compounds according to the invention on an industrial scale, are converted into pharmacologically tolerable salts by methods known to the person skilled in the art.
- the compounds according to the invention and their salts may comprise varying amounts of solvents. Accordingly, the invention also embraces all solvates and in particular all hydrates of the compounds of formula 1, and also all solvates and in particular all hydrates of the salts of the compounds of formula 1.
- R1 is 1-4C-alkyl
- R2 is 1-4C-alkoxy, 3-6C-cycloa)koxy, 3-6C-cycloalkylmethoxy, or 1-4C-alkoxy which is completely or predominantly substituted by fluorine
- R3 is 1-4C-alkoxy, 3-6C-cycloalkoxy, 3-6C-cycloalkylmethoxy, or 1-4C-alkoxy which is completely or predominantly substituted by fluorine
- R4 is hydrogen, halogen, nitro, 1-4C-alkyl, trifluoromethyl or 1-4C-alkoxy
- R5 is a radical of the formulae (a), (b) or (c)
- R7 is hydrogen
- R8 is hydrogen, 1-4C-alkyl, 3-7C-cycloalkyl, 3-7C-cycloalkylmethyl or 1-4C-alkoxy-2-4C-alkyl, and
- R9 is hydrogen, 1-4C-aIkyl, 3-7C-cycloalkyl, 3-7C-cycloalkylmethyl or 1-4C-alkoxy-2-4C-alkyl, with the proviso that at least one of R8 or R9 is 1-4C-alkoxy-2-4C-alkyl, or
- R6 is hydrogen
- R7 is hydrogen, 1-4C-alkyl, 3-7C-cycloalkyl or 3-7C-cycloalkylmethyl, and
- R8 and R9 together and including the nitrogen atom to which both are bonded, are a piperazin-
- 1-yl radical substituted in 4-position by R17 a azocan-1-yl, azonan-1-yl, azecan-1-yl, tetrahydro- isoquinolin-2-yl, tetrahydro-6,7-dimethoxyisoquinolin-2-yl, 3,5-dimethyl-pyrazol-1-yl, pyrazol-1-yl,
- R6 is hydrogen
- R7 is hydrogen, 1-7C-alkyl, 3-7C-cycloalkyl or 3-7C-cycloalkylmethyl,
- R8 is hydrogen, 1-7C-alkyl, 3-7C-cycloalkyl or 3-7C-cycloalkylmethyl, and
- R9 is cyano, Aryll, R26, naphthyl, phenyl, phenyl substituted by R18 and/or R19, phenyl-1-4C- alkyl or phenyl-1-4C-alkyl substituted in the phenyl moiety by R20 and/or R21,
- R10 and R11 independently of one another are hydrogen, 1-4C-alkyl, 3-7C-cycloalkyl or 3-7C-cycloalkylmethyl, and
- R12 and R13 are a pipera- zin-1-yl radical substituted in 4-position by R17, a azocan-1-yl, azonan-1-yl, azecan-1-yl, tetrahy- droisoquinolin-2-yl, tetrahydro-6,7-dimethoxyisoquinolin-2-yl, 3,5-dimethyl-pyrazol-1-yl, pyrazol- 1-yl, 2,6-dimethyl-morpholin-4-yl, 4-benzyl-piperidin-1-yl or 2,6-dimethyl-piperidin-1-yl radical, or
- R10 and R11 together and including the nitrogen atom to which both are bonded, are a 2,6-di- methyl-morpholin-4-yl, 4-benzyl-piperidin-1-yl or 2,6-dimethyl-piperidin-1-yl radical, and R12 and R13, together and including the nitrogen atom to which both are bonded, are a pyrroli- din-1-yl, piperidin-1-yl, hexahydroazepin-1-yl, morpholin-4-yl, 4-(1-4C-alkyl-)-piperazin-1-yl, 2,6-dimethyl-morpholin-4-yl, 4-benzyl-piperidinyl or 2,6-dimethyl-piperidin-1-yl radical,
- R5 is a radical of the formula (c)
- R14 is hydrogen
- R15 and R16 together and with inclusion of the N-C(-)-N structure to which they are bonded are Aryl2
- Aryll is 4-methylthiazol-2-yl, benzimidazol-2-yl, 5-nitrobenzimidazol-2-yl, 5-chlorobenzimidazol-2-yl, 5-methylbenzimidazol-2-yl, benzothiazol-2-yl or benzoxazol-2-yl,
- Aryl2 is 1-methyl-4-oxo-4,5-dihydro-1 H-imidazol-2-yl, imidazol-2-yl, 4,5-dicyano-imidazol-2-yl, 4-me- thyl-imidazol-2-yl, 4-ethyl-benzimidazol-2-yl, 4-acetyl-imidazol-2-yi, 1H-[1,2,4]triazol-3-yl, benz- imidazol-2-yl, 1-methyl-benzimidazol-2-yl, 1-ethyl-benzimidazol-2-yl, 5,6-dimethyl-benzimidazol- 2-yl, purin-8-yl, 6-amino-7-methyl-7H-purine-8-yl, 1,6-dimethylimidazo[4,5-b]pyridin-2-yl, 1 ,5,6- trimethylimidazo[4,5-b]pyridin-2-yl, 1 ,3-d
- R17 is formyl, 3-7C-cycloalkyl, 3-7C-cycloalkylmethyl, 1-4C-alkoxycarbonyl-1-4C-alkyl, 1-4C- alkylcarbonyl, hydroxyethyl, 1-2C-alkoxyethyl, hydroxy-2-4C-alkoxyethyl, 1-2C-alkoxy-2-4C- alkoxyethyl, phenyl, phenyl substituted by R22 and/or R23, [benzo(1,3)dioxol]-5-ylmethyl, phenyl-1 -4C-alkyl or phenyl-1-4C-alkyl substituted in the phenyl moiety by R24 and/or R25,
- R18 is halogen, nitro, 1-4C-alkyI, trifluoromethyl or 1-4C-alkoxy,
- R19 is halogen, 1-4C-alkyl or 1-4C-alkoxy
- R20 is halogen, nitro, 1-4C-alkyl, trifluoromethyl or 1-4C-alkoxy,
- R21 is halogen, 1-4C-alkyl or 1-4C-alkoxy
- R22 is halogen, nitro, 1-4C-alkyl, 1-4C-alkylcarbonyl, trifluoromethyl or 1-4C-alkoxy,
- R23 is halogen, 1-4C-alkyl or 1-4C-alkoxy
- R24 is halogen, nitro, 1-4C-alkyl, trifluoromethyl or 1-4C-alkoxy,
- R25 is halogen, 1-4C-alkyl or 1-4C-alkoxy
- R26 is R27(R28)N-2-4C-alkyl wherein
- R27 and R28 together and including the nitrogen atom to which both are bonded, are a pyrrolidin-1-yl, piperidin-1-yl, piperazin-1-yl, 4-(1-4C-alkyl-)piperazin-1-yl, azepan-1yl, azocan-1-yl, azonan-1-yl, azecan-1-yl, morpholin-4-yl or thiomorpholin-4-yl radical, the salts of these compounds, as well as the N-oxides, enantiomers, E/Z isomers and tautomers of these compounds and their salts.
- R1 is methyl
- R2 is 1-4C-alkoxy
- R3 is 1-4C-alkoxy
- R4 is hydrogen
- R5 is a radical of the formulae (a), (b) or (c)
- R6 is hydrogen
- R7 is hydrogen
- R8 is hydrogen or methoxy-2-4C-alkyl
- R9 is methoxy-2-4C-alkyl
- R6 is hydrogen
- R7 is hydrogen
- R8 and R9 together and including the nitrogen atom to which both are bonded, are a piperazin-
- 1-yl radical substituted in 4-position by R17 a tetrahydroisoquinolin-2-yl, tetrahydro-6,7- dimethoxyisoquinolin-2-yl, 3,5-dimethyl-pyrazol-1-yl, pyrazol-1-yl, azocan-1-yl, azonan-1-yl, azecan-1-yl, 4-benzyl-piperidin-1-yl or thiomorpholin-4-yl radical, or
- R6 is hydrogen
- R7 is hydrogen
- R8 is hydrogen
- R9 is cyano, Aryll , morpholin-4-ylethyl, naphthyl, phenyl, phenyl-1-2C-alkyl, 3,4- dimethoxybenzyl or 3,4-dimethoxyphenylethyl,
- R5 is a radical of the formula (b)
- R10 is hydrogen
- R11 is hydrogen
- R12 and R13 together and including the nitrogen atom to which both are bonded, are a pipera- zin-1-yl radical substituted in 4-position by R17, a tetrahydroisoquinolin-2-yl, tetrahydro-6,7- dimethoxyisoquinolin-2-yl, 4-benzyl-piperidin-1-yl, 3,5-dimethyl-pyrazol-1-yl, pyrazol-1-yl, azocan-1-yl, azonan-1-yl or azecan-1-yl radical,
- R5 is a radical of the formula (c)
- R14 is hydrogen
- R15 and R16 together and with inclusion of the N-C(-)-N structure to which they are bonded
- Aryl2 is 4-methylthiazol-2-yl, benzimidazol-2-yl or benzothiazol-2-yI
- Aryl2 is 1-methyl-4-oxo-4,5-dihydro-1 H-imidazol-2-yl, imidazol-2-yl or benzimidazol-2-yl
- R17 is acetyl, (2-hydroxyethoxy)ethyl, cyclohexyl, ethoxycarbonylmethyl, phenyl, [benzo(1 ,3)dioxol]-
- Preferred compounds of formula 1 are those in which
- R1 is methyl
- R2 is methoxy or ethoxy
- R3 is methoxy
- R4 is hydrogen
- R5 is a radical selected from
- R1 is 1-4C-alkyl
- R2 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy, or 1-4C-a)koxy which is completely or predominantly substituted by fluorine
- R3 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy, or 1-4C-alkoxy which is completely or predominantly substituted by fluorine, or in which
- R2 and R3 together are a 1-2C-alkylenedioxy group
- R4 is hydrogen, halogen, nitro, 1-4C-alkyl, trifluoromethyl or 1-4C-alkoxy
- R5 is a radical of the formulae (a), (b) or (c)
- R6 is hydrogen, 1-7C-alkyl, 3-7C-cycloalkyi, 3-7C-cycloalkylmethyl or hydroxy-2-4C-alkyl
- R7 is hydrogen, 1-7C-alkyl, 3-7C-cycloalkyl, 3-7C-cycloalkylmethyl or hydroxy-2-4C-alkyl
- R8 and R9, together and including the nitrogen atom to which both are bonded, are a piperazin- 1-yl radical substituted in 4-position by R17, a azocan-1-yl, azonan-1-yl, azecan-1-yl, tetrahydro- isoquinolin-2-yl, 3,5-dimethyl-pyrazol-1-yl, pyrazol-1-yl, 2,6-dimethyl-morpholin-4-yl, 2,6-dime- thyl-piperidin-1-yl, thiomorpholin-4-yl or 1 H-1,2,4-triazol-1-y
- R6 is hydrogen, 1-7C-alkyl, 3-7C-cycloalkyl, 3-7C-cycloalkylmethyl or hydroxy-2-4C-alkyi
- R7 is hydrogen, 1-7C-alkyl, 3-7C-cycloaIkyl, 3-7C-cycloalkylmethyl or hydroxy-2-4C-alkyl
- R8 is hydrogen, 1-7C-alkyl, 3-7C-cycloalkyl, 3-7C-cycloalkylmethyl or hydroxy-2-4C-alkyl
- R9 is Aryll, naphthyl, phenyl, phenyl substituted by R18 and/or R19, phenyl-1-4C-alkyl or phenyl-1-4C-alkyl substituted in the phenyl moiety by R20 and/or R21 ,
- R10 and R11 independently of one another are hydrogen, 1-7C-alkyl, 3-7C-cycloalkyl, 3-7C-cy- cloalkylmethyl or hydroxy-2-4C-alkyl, and
- R12 and R13 are a pipera- zin-1-yl radical substituted in 4-position by R17, a azocan-1-yl, azonan-1-yl, azecan-1-yl, tetrahydroisoquinolin-2-yl, 3,5-dimethyl-pyrazo!-1 -yl, pyrazol-1 -yl, 2,6-dimethyl-morpholin-4-yl, 2,6-dimethyl-piperidin-1-yl, thiomorpholin-4-yl or 1H-1 ,2,4-triazol-1-yl radical, or
- R10 and R11 together and including the nitrogen atom to which both are bonded, are a 2,6-di- methyl-morpholin-4-yl, 2,6-dimethyl-piperidin-1-yl or thiomorpholin-4-yl radical
- R12 and R13 together and including the nitrogen atom to which both are bonded, are a pyrroli- din-1-yl, piperidin-1-yl, hexahydroazepin-1-yl, morpholin-4-yl, 4-(1-4C-alkyl-)-piperazin-1-yl, 2,6-dimethyl-morpholin-4-yl, 2,6-dimethyl-piperidin-1-yl or thiomorpholin-4-yl radical,
- R14 is hydrogen, 1-7C-alkyl, 3-7C-cycloalkyl, 3-7C-cycloalkylmethyl or hydroxy-2-4C-alkyl, and
- Aryll is 4-methylthiazol-2-yl, benzimidazol-2-yl, 5-nitrobenzimidazol-2-yl, 5-chiorobenzimidazol-2-yl,
- Aryl2 is 1-methyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl, imidazol-2-yl, 4,5-dicyano-imidazol-2-yl, 4-me- thyl-imidazol-2-yl, 4-ethyl-benzimidazol-2-yl, 4-acetyl-imidazol-2-yl, 1H-[1 ,2,4]triazol-3-yl, benz- imidazol-2-yl, 1 -methyl-benzimidazol-2-yl, 1 -ethyl-benzimidazol-2-yl, 5,6-dimethyl-benzimidazol- 2-yl, purin-8-yl, 6-amino-7-methyl-7H-
- R17 is formyl, 1-4C-alkylcarbonyl, 2-hydroxyethyl, phenyl, phenyl substituted by R22 and/or R23, phenyI-1-4C-alkyl or phenyl-1-4C-alkyl substituted in the phenyl moiety by R24 and/or R25,
- R18 is halogen, nitro, carboxyl, 1-4C-alkyl, trifluoromethyl or 1-4C-alkoxy,
- R19 is halogen, 1-4C-alkyl or 1-4C-alkoxy
- R20 is halogen, nitro, carboxyl, 1-4C-alkyl, trifluoromethyl or 1-4C-alkoxy,
- R21 is halogen, 1-4C-alkyl or 1-4C-alkoxy
- R22 is halogen, nitro, carboxyl, 1-4C-alkyl, trifluoromethyl or 1-4C-alkoxy,
- R23 is halogen, 1-4C-alkyl or 1-4C-alkoxy
- R24 is halogen, nitro, carboxyl, 1-4C-alkyl, trifluoromethyl or 1-4C-alkoxy,
- R25 is halogen, 1-4C-alkyl or 1-4C-alkoxy, the salts of these compounds, as well as the N-oxides, enantiomers, E/Z isomers and tautomers of these compounds and their salts.
- R1 is 1-4C-alkyl
- R2 is 1-4C-alkoxy, 3-6C-cycloalkoxy, 3-6C-cycloalkylmethoxy, or 1-4C-alkoxy which is completely or predominantly substituted by fluorine
- R3 is 1-4C-alkoxy, 3-6C-cycloalkoxy, 3-6C-cycloalkylmethoxy, or 1-4C-alkoxy which is completely or predominantly substituted by fluorine
- R4 is hydrogen, halogen, nitro, 1-4C-alkyl, trifluoromethyl or 1-4C-alkoxy
- R5 is a radical of the formulae (a), (b) or (c)
- R6 is hydrogen
- R7 is hydrogen, 1-4C-alkyl, 3-7C-cycloalkyl or 3-7C-cycloalkylmethyl
- R8 and R9 are a piperazin- 1-yl radical substituted in 4-position by R17, a azocan-1-yl, azonan-1-yl, azecan-1-yl, tetrahydro- isoquinolin-2-yl, 3,5-dimethyl-pyrazol-1-yl, pyrazol-1-yl, 2,6-dimethyl-morpholin-4-yl or 2,6-dime- thyl-piperidin-1-yl radical, or
- R6 is hydrogen
- R7 is hydrogen, 1-7C-alkyl, 3-7C-cycloalkyl or 3-7C-cycloalkylmethyl,
- R8 is hydrogen, 1-7C-alkyl, 3-7C-cycloalkyl or 3-7C-cycloalkylmethyl, and
- R9 is Aryll, naphthyl, phenyl, phenyl substituted by R18 and/or R19, phenyl-1-4C-alkyl or phenyl-1-4C-alkyl substituted in the phenyl moiety by R20 and/or R21 ,
- R10 and R11 independently of one another are hydrogen, 1-4C-alkyl, 3-7C-cycloalkyl or
- R12 and R13 together and including the nitrogen atom to which both are bonded, are a pipera- zin-1-yl radical substituted in 4-position by R17, a azocan-1-yl, azonan-1-yl, azecan-1-yl, tetrahy- droisoquinolin-2-yl, 3,5-dimethyl-pyrazol-1-yl, pyrazol-1-yl, 2,6-dimethyl-morpholin-4-y! or 2,6-di- methyl-piperidin-1-yl radical, or
- R10 and R11 together and including the nitrogen atom to which both are bonded, are a 2,6-di- methyl-morpholin-4-yl or 2,6-dimethyl-piperidin-1-yl radical, and
- R12 and R13 together and including the nitrogen atom to which both are bonded, are a pyrroli- din-1-yl, piperidin-1-yl, hexahydroazepin-1-yl, morpholin-4-yl, 4-(1-4C-alkyl-)-piperazin-1-yl,
- R5 is a radical of the formula (c)
- R14 is hydrogen
- R15 and R16 together and with inclusion of the N-C(-)-N structure to which they are bonded are Aryl2,
- Aryll is 4-methylthiazol-2-yl, benzimidazol-2-yl, 5-nitrobenzimidazol-2-yl, 5-chlorobenzimidazol-2-yl, 5-methylbenzimidazol-2-yl, benzothiazol-2-yl or benzoxazol-2-yl,
- Aryl2 is 1-methyl-4-oxo-4,5-dihydro-1 H-imidazol-2-yl, imidazol-2-yl, 4,5-dicyano-imidazol-2-yl, 4-me- thyl-imidazol-2-yl, 4-ethyl-benzimidazol-2-yl, 4-acetyl-imidazol-2-yl, 1H-[1,2,4]triazol-3-yl, benz- imidazol-2-yl, 1 -methyl-benzimidazol-2-yl, 1 -ethyl-benzimidazol-2-yl, 5,6-dimethyl-benzimidazol- 2-yl, purin-8-yl, 6-amino-7-methyl-7H-purine-8-yl, 1 ,6-dimethylimidazo[4,5-b]pyridin-2-yl, 1,5,6- trimethylimidazo[4,5-b]pyridin-2-yl, 1
- R17 is formyl, 1-4C-alkylcarbonyl, 2-hydroxyethyl, phenyl, phenyl substituted by R22 and/or R23, phenyl-1-4C-alkyl or phenyl-1-4C-alkyl substituted in the phenyl moiety by R24 and/or R25
- R18 is halogen, nitro, 1-4C-alkyl or 1-4C-alkoxy
- R19 is halogen, 1-4C-aikyl or 1-4C-alkoxy
- R20 is halogen, nitro, 1-4C-alkyl or 1-4C-alkoxy
- R21 is halogen, 1-4C-alkyl or 1-4C-aIkoxy
- R22 is halogen, nitro, 1-4C-alkyl or 1-4C-alkoxy
- R23 is halogen, 1-4C-alkyl or 1-4C-alkoxy
- R17 is formyl, 1-4C-
- R1 is methyl
- R2 is 1-4C-alkoxy
- R3 is 1-4C-alkoxy
- R4 is hydrogen
- R5 is a radical of the formulae (a), (b) or (c)
- R6 is hydrogen
- R7 is hydrogen
- R8 and R9 together and including the nitrogen atom to which both are bonded, are a piperazin-
- R6 is hydrogen
- R7 is hydrogen
- R8 is, hydrogen or 1-4C-alkyl
- R9 is Aryll , naphthyl or phenyl-1-2C-aikyl
- R10 is hydrogen or 1-4C-alkyl
- R11 is hydrogen or 1-4C-alkyl
- R12 and R13 together and including the nitrogen atom to which both are bonded, are a pipera- zin-1-yl radical substituted in 4-position by R17, a tetrahydroisoquinolin-2-yl, 3,5-dimethyl-pyra- zol-1-yl, pyrazol-1-yl, azocan-1-yl, azonan-1-yl or azecan-1-yl radical,
- R14 is hydrogen
- Aryl2 is 4-methylthiazol-2-yl or benzothiazol-2-yl
- Aryl2 is 1-methyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl, imidazol-2-yl, 4-methyl-imidazol-2-yl, 4-ethyl- benzimidazol-2-yl, 4-acetyl-imidazol-2-yl, benzimidazol-2-yl, 1-methyl-benzimidazol-2-yl, 1-ethyl- benzimidazol-2-yl or 5,6-dimethyl-benzimidazol-2-yl
- R17 is acetyl, 2-methoxyphenyl or benzyl, the salts of these compounds, as well as the N-oxides, enantiomers, E/Z isomers and tautomers of these compounds and their salts.
- Preferred compounds of formula 1 of embodiment A are those in which
- R1 is methyl
- R2 is methoxy or ethoxy
- R3 is methoxy
- R4 is hydrogen
- R5 is N-(1-methyl-4-oxo-4,5-dihydro-1 H-imidazol-2-yl)-amino, N-(1-amino-1-azocan-1-yl-methyle- ne)-amino, N-[1-(4-acetylpiperazine-1-yl)-1-amino-methylene]-amino, N-(N'-(R)-1-phenylethyl)- guanidinyl, N-(N'-(S)-1-phenylethyl)guanidinyl, N-[1 -amino-1 -(4-benzylpiperazine-1-yl)-methyle- ne]-amino, N-[1 -amino-1 -(2-methoxy-phenyl-piperazin-1-yl)-methylene]-amino, N-[1-(3,5-dimeth- yl-pyrazoI-1 -yl
- R1 is 1-4C-alkyl
- R2 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy, or 1-4C-alkoxy which is completely or predominantly substituted by fluorine
- R3 is hydroxyl, 1-4C-alkoxy, 3-7C-cycloalkoxy, 3-7C-cycloalkylmethoxy, or 1-4C-alkoxy which is completely or predominantly substituted by fluorine, or in which
- R2 and R3 together are a 1-2C-alkylenedioxy group
- R4 is hydrogen, halogen, nitro, 1-4C-alkyl, trifluoromethyl or 1-4C-alkoxy
- R5 is a radical of the formula (a)
- R6, R7, R8 and R9 independently of one another are hydrogen, 1-7C-alkyl, 3-7C-cycloalkyl,
- R6 is hydrogen, 1-7C-alkyl, 3-7C-cycloalkyl, 3-7C-cycloalkylmethyl, hydroxy-2-4C-alkyl, 1-4C- alkoxy-2-4C-alkyl or R26,
- R7 is hydrogen, 1-7C-alkyl, 3-7C-cycloalkyl, 3-7C-cycloalkylmethyl, hydroxy-2-4C-alkyl, 1-4C- alkoxy-2-4C-alkyl or R26, and
- R8 and R9 together and including the nitrogen atom to which both' are bonded, are a piperazin-
- R6 is hydrogen, 1-7C-alkyl, 3-7C-cycloalkyl, 3-7C-cycloalkylmethyl, hydroxy-2-4C-alkyl, 1-4C- alkoxy-2-4C-alkyl or R26,
- R7 is hydrogen, 1-7C-alkyl, 3-7C-cycloalkyl, 3-7C-cycloalkylmethyl, hydroxy-2-4C-alkyl, 1-4C- alkoxy-2-4C-alkyl or R26,
- R8 is hydrogen, 1-7C-alkyl, 3-7C-cycloalkyl, 3-7C-cycloalkylmethyl, hydroxy-2-4C-alkyl, 1-4C- alkoxy-2-4C-alkyl or R26, and
- R9 is cyano or R26
- R17 is 3-7C-cycloalkyl, 3-7C-cycloalkylmethyl, 1-4C-alkoxycarbonyl-1-4C-alkyl, 1-4C-alkoxy-2-4C- alkyl, hydroxy-2-4C-alkoxy-2-4C-alkyl, 1-4C-alkoxy-2-4C-alkoxy-2-4C-alkyl, 1-4C- alkylcarbonylphenyl or [benzo(1,3)dioxol]-5-ylmethyl, R26 is R27(R28)N-2-4C-alkyl wherein
- R27 and R28 together and including the nitrogen atom to which both are bonded, are a pyrrolidin-1-yl, piperidin-1-yl, piperazin-1-yl, 4-(1-4C-alkyl-)piperazin-1-yl, azepan-1yl, azocan-1-yl, azonan-1-yl, azecan-1-yl, tetrahydroisoquinolin-2-yl, tetrahydro-6,7-dimethoxyisoquinolin-2-yl, 3,5-dimethyl- pyrazol-1-yl, pyrazol-1-yl, morpholin-4-yl, 2,6-dimethyl-morpholin-4-yl, 2,6-dimethyl-piperidin-1-yl, 4-benzyl-piperidin-1-yl, thiomorphoIin-4-yl or 1 H-1 ,2,4-triazol-1-yl radical, the salts of these compounds, as well as the
- R1 is 1-4C-a)kyl
- R2 is 1-40-alkoxy, 3-60-cycloalkoxy, 3-60-cycloalkylmethoxy, or 1-40-alkoxy which is completely or predominantly substituted by fluorine
- R3 is 1-40-alkoxy, 3-60-cycloalkoxy, 3-60-cycloalkylmethoxy, or 1-40-alkoxy which is completely or predominantly substituted by fluorine
- R4 is hydrogen, halogen, nitro, 1-4C-alkyl, trifluoromethyl or 1-40-alkoxy
- R5 is a radical of the formula (a)
- R6 is hydrogen
- R7 is hydrogen
- R8 is hydrogen, 1-4C-alkyl, 3-7C-cycloalkyl, 3-7C-cycloalkylmethyl or 1-4C-alkoxy-2-4C-alkyl, and
- R9 is hydrogen, 1-4C-alkyl, 3-7C-cycloalkyl, 3-7C-cycloalkylmethyl or 1-4C-alkoxy-2-4C-alkyl, with the proviso that at least one of R8 or R9 is 1-4C-alkoxy-2-4C-alkyl, or
- R6 is hydrogen
- R7 is hydrogen, 1-4C-alkyl, 3-7C-cycloalkyl or 3-7C-cycloalkylmethyl, and
- R8 and R9 together and including the nitrogen atom to which both are bonded, are a piperazin-
- R6 is hydrogen
- R7 is hydrogen, 1-7C-alkyl, 3-7C-cycloalkyl or 3-7C-cycloalkylmethyl
- R8 is hydrogen, 1-7C-alkyl, 3-7C-cycloalkyl or 3-7C-cycloalkylmethyl
- R9 is cyano or R26
- R17 is 3-7C-cycloalkyl, 3-7C-cycloalkylmethyl, 1-4C-alkoxycarbonyl-1-4C-aIkyl, 1-2C-alkoxyethyl, hydroxy-2-4C-alkoxyethyl, 1-2C-alkoxy-2-4C-alkoxyethyl, 1-4C-alkylcarbonylphenyl or
- R26 is R27(R28)N-2-4C-alkyl wherein R27 and R28, together and including the nitrogen atom to which both are bonded, are a pyrrolidin-1-yl, piperidin-1-yl, piperazin-1-yl, 4-(1-4C-alkyl-)piperazin-1-yl, azepan-1yl, azocan-1-yl, azonan-1-yl, azecan-1-yl, morpholin-4-yl or thiomorpholin-4-yl radical, the salts of these compounds, as well as the N-oxides, enantiomers, E/Z isomers and tautomers of these compounds and their salts.
- R1 is methyl
- R2 is 1-40-alkoxy
- R3 is 1-40-alkoxy
- R4 is hydrogen
- R5 is a radical of the formula (a)
- R6 is hydrogen
- R7 is hydrogen
- R8 is hydrogen or methoxy-2-4C-alkyl
- R9 is methoxy-2-4C-alkyl
- R6 is hydrogen
- R7 is hydrogen
- R8 and R9 together and including the nitrogen atom to which both are bonded, are a piperazin-
- R7 is hydrogen
- R8 is hydrogen
- R9 is cyano or morpholin-4-ylethyl
- R17 is (2-hydroxyethoxy)ethyl, cyclohexyl, ethoxycarbonylmethyl, [benzo(1 ,3)dioxol]-5-ylmethyl or 4- acetylphenyl, the salts of these compounds, as well as the N-oxides, enantiomers, E/Z isomers and tautomers of these compounds and their salts.
- a special embodiment of the compounds of the present invention include those compounds of formula 1 , in which R1 is methyl, R2 is ethoxy and R3 is methoxy.
- Another special embodiment of the compounds of the present invention include those compounds of formula 1 in which R1 is methyl, R2 is ethoxy, R3 is methoxy and R4 is hydrogen. Still another special embodiment of the compounds of the present invention include those compounds of formula 1 in which R1 is methyl, R2 is ethoxy, R3 is methoxy, R4 is hydrogen and the radical -C(0)-R5 is attached to the 6-phenyl-ring in para-position.
- a further special embodiment of the compounds of the present invention include those compounds of formula 1 in which R1 is methyl, R2 is ethoxy, R3 is methoxy, R4 is hydrogen, the radical -C(0)-R5 is attached to the 6-phenyl-ring in para-position and R5 is a radical of formulae (a) or (b).
- Still a further special embodiment of the compounds of the present invention include those compounds of formula 1 in which R1 is methyl, R2 is ethoxy, R3 is methoxy, R4 is hydrogen, the radical -C(0)-R5 is attached to the 6-phenyl-ring in para-position and R5 is a radical of formula (c).
- the compounds of formula 1 are chiral compounds having chiral centers in positions 4a and 10b
- the invention therefore includes all conceivable pure diastereomers and pure enantiomers and mixtures thereof in any mixing ratio, including the racemates. Preference is given to compounds of formula 1 in which the hydrogen atoms in positions 4a and 10b are in the cis position relative to one another. The pure cis enantiomers and their mixtures in any mixing ratio and including the racemates are particularly preferred.
- the enantiomers can be separated in a known manner (for example by preparing and separating corresponding diastereoisomeric compounds) or by stereoselective synthesis methods. Such separation processes and synthesis methods are described, for example, in EP 247 971 and in DE 42 17401.
- the compounds according to the invention can be prepared, for example, as shown in the reaction schemes below.
- Reaction scheme 1 In a first reaction step, compounds of formula 7, in which R1 , R2 and R3 have the meanings given above, are reacted with compounds of formula 6, in which R4 has the meaning given above, R is, for example, 1-4C-alkyl and X is a suitable leaving group, for example a chlorine atom.
- R is, for example, 1-4C-alkyl
- X is a suitable leaving group, for example a chlorine atom.
- the compounds of formula 4 are obtained by cyclocondensation of the compounds of formula 5 obtained in the first reaction step.
- cyclocondensation is carried out in a manner known per se to the person skilled in the art according to Bischler-Napieralski (e.g. as described in J. Chem. Soc, 1956, 4280-4282) in the presence of a suitable condensing agent, such as, for example, polyphosphoric acid, phosphorus pentachloride, phosphorus trichloride, phosphorus pentoxide, thionyl chloride or preferably phosphorus oxytrichloride, in a suitable inert solvent, e.g.
- a chlorinated hydrocarbon such as chloroform
- a cyclic hydrocarbon such as toluene or xylene
- another inert solvent such as acetonitrile
- an excess of condensing agent preferably at elevated temperature, in particular at the boiling point of the solvent or condensing agent used.
- the compounds of formula 1 can be obtained by different routes.
- the compounds of formula 1 can be obtained from the compounds of formula 4 by direct reaction with compounds of formula R5-H, in which R5 has the meanings given above.
- reaction scheme 2 An alternative synthesis route for compounds of formula 1 is shown in reaction scheme 2.
- the acid halide (compounds of formula 6) is then reacted with compounds of the formula R5-H, in which R5 has the meanings given above.
- the ester group of the resulting guanidine derivatives (compounds of formula 11) is hydrolyzed and the resulting acids (compounds of formula 10) are activated, for example by conversion into an acid halide (compounds of formula 9).
- Suitably substituted phthalic acid, isophthalic acid or terephthalic acid monoester derivatives are either known or can be prepared by methods known to the person skilled in the art.
- Exemplary compounds of formula 6 which may be mentioned are methyl 4-chloro- carbonylbenzoate (preparation described in J. Amer. Chem. Soc. 79, (1957), 96 or in Bioorg. Med. Chem. Lett. 1999, 227-232) and methyl 3-chlorocarbonylbenzoate (preparation described in J. Med. Chem. 1999, 2621-2632).
- the substances according to the invention are isolated and purified in a manner known per se, for example by distilling off the solvent under reduced pressure and recrystallizing the residue obtained from a suitable solvent or subjecting it to one of the customary purification methods, such as, for example, column chromatography on a suitable support material.
- Salts are obtained by dissolving the free compound in a suitable solvent (e.g. a ketone, such as acetone, methyl ethyl ketone or methyl isobutyl ketone, an ether, such as diethyl ether, tetrahydrofuran or dioxane, a chlorinated hydrocarbon, such as methylene chloride or chloroform, or a low-molecular- weight aliphatic alcohol, such as ethanol or isopropanol) which contains the desired acid or base, or to which the desired acid or base is then added.
- a suitable solvent e.g. a ketone, such as acetone, methyl ethyl ketone or methyl isobutyl ketone, an ether, such as diethyl ether, tetrahydrofuran or dioxane, a chlorinated hydrocarbon, such as methylene chloride or chloroform, or a low-molecular- weight
- m.p. stands for melting point
- h for hour(s)
- RT room temperature
- EF empirical formula
- MW molecular weight
- This solution is added to a suspension of 0.41 g of creatinine in a mixture of 50 ml acetonitrile and 2.6 ml of diisopropyl amine.
- the reaction mixture is stirred at RT overnight and filtered.
- the filtrate is substantially concentrated under reduced pressure, and the highly viscous residue is partitioned between dichlorometha- ne and saturated sodium bicarbonate solution.
- the organic phase is washed with water, dried over sodium sulfate and concentrated.
- the resin-like residue is purified by silica gel chromatography, and the product fraction is separated off and concentrated. This gives 0.33 g of the title compound as solid foam.
- the compounds according to the invention have valuable pharmacological properties which make them commercially utilizable.
- selective inhibitors of type 4 or type 3 and 4 of cyclic nucleotide phosphodiesterase PDE4, PDE3/4
- they are suitable on the one hand as bronchial therapeutics (for the treatment of airway obstructions on account of their dilating action and cilia-stimulating action but also on account of their respiratory rate- and respiratory drive-increasing action), but on the other hand especially for the treatment of disorders of inflammatory nature, e.g.
- mediators such as interferons, members of the tumour necrosis factor family, interleukins, chemokines, colony- stimulating factors, growth factors, lipid mediators (e.g., inter alia, PAF, platelet-activating factor), bacterial factors (e.g. LPS), immunoglobulins, oxygen free radicals and related free radicals (e.g. nitrogen monoxide NO), biogenic amines (e.g. histamine, serotonin), kinins (e.g.
- bradykinin neurogenic mediators (such as substance P, neurokinin), proteins such as, for example, granular contents of leukocytes (inter alia cationic proteins of eosinophils) and adherence proteins (e.g. integrins).
- the compounds according to the invention have smooth muscle-relaxant action, e.g. in the region of the bronchial system, of the blood circulation, and of the efferent urinary passages. Furthermore, they have cilia frequency-increasing action, for example in the bronchial system.
- the compounds according to the invention can be employed as therapeutics in human and veterinary medicine, where they can be used, for example, for the treatment and prophylaxis of the following diseases: acute and chronic (in particular inflammatory and allergen-induced) respiratory disorders of various origins (bronchitis, allergic bronchitis, bronchial asthma, emphysema, COPD); disorders associated with impaired cilia function or increased demands on ciliar clearance (bronchitis, mucoviscidosis), dermatoses (especially of proliferative, inflammatory and allergic type) such as, for example, psoriasis (vulgaris), toxic and allergic contact eczema, atopic eczema, seborrheic eczema, lichen simplex, sunburn, pruritus in the anogenital area, alopecia areata, hypertrophic scars, discoid lupus erythematosus, folli
- acute and chronic respiratory disorders of various origins
- the compounds according to the invention can also be used for the treatment of high blood pressure disorders of various origins such as, for example, pulmonary high blood pressure and the concomitant symptoms associated therewith, for the treatment of erectile dysfunction or colics of the kidneys and the ureters in connection with kidney stones.
- PDE inhibitors such as, for example, cardiac insufficiency, and also as anti- thrombotic, platelet aggregation-inhibiting substances.
- the invention further relates to a method for the treatment of mammals including humans who are suffering from one of the abovementioned diseases.
- the method comprises administering a therapeuti- cally effective and pharmacologically acceptable amount of one or more of the compounds according to the invention to the sick mammal.
- the invention further relates to the compounds according to the invention for use in the treatment and/or prophylaxis of diseases, in particular the diseases mentioned.
- the invention also relates to the use of the compounds according to the invention for the production of pharmaceutical compositions which are employed for the treatment and/or prophylaxis of the diseases mentioned.
- the invention furthermore relates to pharmaceutical compositions for the treatment and/or prophylaxis of the diseases mentioned and which contain one or more of the compounds according to the invention.
- a further subject of the invention is a commercial product, consisting of a customary secondary pack, a primary pack containing the pharmaceutical composition (for example an ampoule or a blister pack) and, if desired, an information leaflet, the pharmaceutical composition exhibiting antagonistic action against cyclic nucleotide phosphodiesterases of type 4 or types 3 and 4 and leading to the attenuation of the symptoms of illnesses which are connected with cyclic nucleotide phosphodiesterases of type 4 or types 3 and 4, and the suitability of the pharmaceutical composition for the prophylaxis or treatment of illnesses which are connected with cyclic nucleotide phosphodiesterases of type 4 or types 3 and 4 being indicated on the secondary pack and/or on the information leaflet of the commercial product, and the pharmaceutical composition containing one or more compounds of formula 1 according to the invention.
- the substances according to the invention are also suitable for combination with other substances which bring about stimulation of cAMP, such as prostaglandins (PGE2, PGI2 and prostacy- clin) and their derivatives, direct adenylate cyclase stimulators such as forskolin and related substances, or substances indirectly stimulating adenylate cyclase, such as catecholamines and adrenergic receptor agonists, in particular beta-mimetics.
- PGE2 prostaglandins
- PGI2 prostacy- clin
- prostacy- clin adenylate cyclase stimulators
- adenylate cyclase such as catecholamines and adrenergic receptor agonists, in particular beta-mimetics.
- they in this case display a synergistic, superadditive activity. This comes to bear, for example, in their use in combination with PGE2 for the treatment of pulmonary hypertension.
- compositions are prepared by processes which are known per se and familiar to the person skilled in the art.
- the compounds according to the invention are either employed as such, or preferably in combination with suitable pharmaceutical auxiliaries and/or excipients, e.g. in the form of tablets, coated tablets, capsules, caplets, suppositories, patches (e.g. as TTS), emulsions, suspensions, gels or solutions, the active compound content advantageously being between 0.1 and 95% and where, by the appropriate choice of the auxiliaries and/or excipients, a pharmaceutical administration form (e.g. a delayed release form or an enteric form) exactly suited to the active compound and/or to the desired onset of action can be achieved.
- suitable pharmaceutical auxiliaries and/or excipients e.g. in the form of tablets, coated tablets, capsules, caplets, suppositories, patches (e.g. as TTS), emulsions, suspensions, gels or solutions, the active compound content advantageously being between
- auxiliaries or excipients which are suitable for the desired pharmaceutical formulations on account of his/her expert knowledge.
- solvents for example antioxidants, dispersants, emulsifiers, preservatives, solubilizers, colorants, complexing agents or permeation promoters, can be used.
- compositions according to the invention may be performed in any of the generally accepted modes of administration available in the art.
- suitable modes of administration include intravenous, oral, nasal, parenteral, topical, transdermal and rectal delivery. Oral delivery is preferred.
- the compounds according to the invention are preferably also administered by inhalation in the form of an aerosol; the aerosol particles of solid, liquid or mixed composition preferably having a diameter of 0.5 to 10 ⁇ m, advantageously of 2 to 6 ⁇ m.
- Aerosol generation can be carried out, for example, by pressure-driven jet atomizers or ultrasonic atomizers, but advantageously by propellant-driven metered aerosols or propellant-free administration of micronized active compounds from inhalation capsules.
- the administration forms additionally contain the required excipients, such as, for example, propellants (e.g. Frigen in the case of metered aerosols), surface-active substances, emulsifiers, stabilizers, preservatives, flavorings, fillers (e.g. lactose in the case of powder inhalers) or, if appropriate, further active compounds.
- propellants e.g. Frigen in the case of metered aerosols
- surface-active substances e.g. Frigen in the case of metered aerosols
- emulsifiers emulsifiers
- stabilizers emulsifiers
- preservatives e.g., emulsifiers, stabilizers, preservatives
- flavorings e.g. lactose in the case of powder inhalers
- fillers e.g. lactose in the case of powder inhalers
- the compounds according to the invention are in particular administered in the form of those pharmaceutical compositions which are suitable for topical application.
- suitable pharmaceutical formulations are, for example, powders, emulsions, suspensions, sprays, oils, ointments, fatty ointments, creams, pastes, gels or solutions.
- compositions according to the invention are prepared by methods known per se.
- the dosage of the active compounds takes place in the order of magnitude customary for PDE inhibitors.
- topical application forms (such as, for example, ointments) for the treatment of dermatoses contain the active compounds in a concentration of, for example, 0.1-99%.
- the dose for administration by inhalation is customarily between 0.1 and 3 mg per day.
- the customary dose in the case of systemic therapy p.o. or i.v.
- the second messenger cyclic AMP (cAMP) is known for inhibiting inflammatory cells and cells responsible for the immunological response.
- the PDE4 isoenzyme is widely distributed in cells associated with the initiation and spreading of inflammatory diseases (H Tenor and C Schudt, in "Phosphodiesterase Inhibitors", 21-40, “The Handbook of Immunopharmacology", Academic Press 1996); its inhibition results in the increase of the intracellular cyclic AMP concentration and thus in the inhibition of cellular activation (JE Souness et al., Immunopharmacology 47: 127-162, 2000).
- neutrophilic C Schudt et al., Arch Pharmacol 344: 682-690, 1991
- eosinophilic A Hatzel- mann et al., Brit J Pharmacol 114: 821-831 , 1995
- granulocytes which can be measured as luminol- enhanced chemiluminescence, or the synthesis of tumor necrosis factor alpha (TNF ⁇ ) in monocytes, macrophages or dendritic cells (Gantner et al., Brit J Pharmacol 121: 221-231, 1997 and Pulmonary Pharmacol Therap 12: 377-386, 1999).
- TNF ⁇ tumor necrosis factor alpha
- the immunomodulatory potential of the PDE4 inhibitors furthermore becomes apparent by inhibition of T-cell responses such as cytokine synthesis or proliferation (DM Essayan, Biochem Pharmacol 57: 965-973, 1999).
- PDE4 inhibition by the substances according to the invention is thus a central indicator of the suppression of inflammatory processes.
- Some of the cells involved in inflammatory processes contain, in addition to PDE4, also the PDE3 isoenzyme which likewise contributes to the total cAMP metabolism of these cells. Examples are endothelial cells, mast cells, T-cells, macrophages and dendritic cells.
- the inhibitory action of PDE4 inhibitors can be enhanced by additional PDE3 inhibition.
- inhibition of the PDE3 activity is furthermore important for (broncho)relaxation (A Hatzelmann et al., in "Phosphodiesterase Inhibitors", 147-160, “The Handbook of Immunopharmacology", Academic Press, 1996).
- the PDE activity was determined according to Thompson et al. (Adv Cycl Nucl Res 10: 69-92, 1979) with some modifications (Bauer and Schwabe, Naunyn-Schmiedeberg's Arch Pharmacol 311 : 193-198, 1980).
- the test samples contained 20 mM Tris (pH 7.4), 5 mM MgCI 2 , 0.5 ⁇ M cAMP or cGMP,
- [ 3 H]cAMP or [ 3 H]cGMP (about 30 000 cpm/sample), the PDE isoenzyme-specific additives described in greater detail below, the indicated concentrations of inhibitor and an aliquot of the enzyme solution in a total sample volume of 200 ⁇ l.
- Dilution series of the compounds according to the invention were prepared in DMSO and further diluted in the samples [1:100 (v/v)], to give the desired end concentration of the inhibitors at a DMSO concentration of 1% (v/v), which for its part has only a minute effect on PDE activity.
- the reaction was started by addition of the substrate (cAMP or cGMP).
- the samples were incubated at 37°C for a further 15 min.
- the reaction was terminated by addition of 50 ⁇ l 0.2 N HCI.
- 25 ⁇ g ⁇ '-nucleotidase (snake venom from Crotalus atrox)
- the mixture was again incubated at 37°C for 10 min and the samples were then applied to QAE Sephadex A-25 columns (sample volume 1 ml). The columns were eluted with 2 ml of 30 mM ammonium formate (pH 6.0).
- the radioactivity of the eluate was measured and corrected by the corresponding blank values (measured in the presence of denatured protein); the blank values were less than 5% of the total radioactivity. In no case did the proportion of hydrolyzed nucleotide exceed 30% of the original substrate concentration.
- PDE3 cGMP-inhibited was investigated in homogenates of human platelets (see Schudt et al., Biochem Pharmacol 1991: 42, 153-162) using cAMP or cGMP as substrate.
- PDE4 cAMP-specific was investigated in the cytosol of human polymorphonuclear leukocytes (PMNL) [isolated from leukocyte concentrates, see Schudt et al., Arch Pharmacol 1991 : 344, 682-690] using cAMP as substrate.
- PMNL human polymorphonuclear leukocytes
- the cDNA for PDE3A1 (GB no. U36798) was isolated in 2 steps using PCR.
- a 3' terminal cDNA fragment of PDE3A1 was amplified from fat cells cDNA (Clontech, Palo Alto) using primers OZ 458 (5'- AAAGTCGACTCACTGGTCTGGCTTTTGG -3') and OZ 457 (5'- GTCGACCAGGTGCCCTCGCTA - 3').
- the 5' terminal cDNA fragment of PDE3A1 was amplified from Placenta cDNA (Clontech, Palo Alto) using primers OZ 455 (5'- ATGGCAGTGCCCGGCGACGCT -3') and OZ 456 (5'- GTCGACTTTGCTTTTTAGCCT -3').
- the PCR products were cloned into pCR2.1-Topo (Invitrogen, Groningen, NL) under standard conditions (the manufacturer's instructions).
- the 3' fragment was cut out with Hindll and cloned into the Hindll site of the construct carrying the 5' fragment.
- the whole ORF was subcloned into pBacPak ⁇ (Clontech, Palo Alto) using EcoRI.
- Aminoacid 12 is Aspartic Acid like in sequence GB no. AJ005036, aa 69 and aa 110 are respective Serine and Glycine like in both sequences GB no. AJ005036 and GB no. M91667.
- the PDE4B2 (GB no. M97515) was a gift of Prof. M. Conti (Stanford University, USA). It was amplified from the original plasmid (pCMV5) via PCR with primers Rb9 (5'- GCCAGCGTGCAAATAATGAAGG - 3') and Rb10 (5'- AGAGGGGGATTATGTATCCAC -3') and cloned into the pCR-Bac vector (Invitrogen, Groningen, NL).
- the recombinant baculovirus was prepared by means of homologous recombination in SF9 insect cells.
- the expression plasmids were cotransfected with Bac-N-Blue (Invitrogen, Groningen, NL) or Baculo-Gold DNA (Pharmingen, Hamburg) using a standard protocol (Pharmingen, Hamburg).
- Wt virus-free recombinant virus supernatants were selected using plaque assay methods. After that, high- titre virus supernatants were prepared by amplifying 3 times.
- PDEs were expressed in SF21 cells by infecting 2x10 6 cells/ml with an MOI (multiplicity of infection) between 1 and 10 in serum-free SF900 medium (Life Technologies, Paisley, UK). The cells were cultured at 28°C for 48 - 72 hours, after which they were pelleted for 5-10 min at 1000 g and 4°C.
- the SF21 insect cells were resuspended, at a concentration of approx. 10 7 cells/ml, in ice-cold (4°C) homogenization buffer (20 mM Tris, pH 8.2, containing the following additions: 140 mM NaCI, 3.8 mM KOI, 1 mM EGTA, 1 mM MgCI 2 , 10 mM ⁇ -mercaptoethanol, 2 mM benzamidine, 0.4 mM Pefablock, 10 ⁇ M leupeptin, 10 ⁇ M pepstatin A, 5 ⁇ M trypsin inhibitor) and disrupted by ultrasonication. The homogenate was then centrifuged for 10 min at 1000 ⁇ g and the supernatant was stored at -80°C until subsequent use (see below). The protein content was determined by the Bradford method (BioRad, Kunststoff) using BSA as the standard.
- PDE3A1 and PDE4B2 activities were inhibited by the said compounds in a modified SPA (scintillation proximity assay) test, supplied by Amersham Biosciences (see procedural instructions "phosphodiesterase [3H]cAMP SPA enzyme assay, code TRKQ 7090"), carried out in 96-well microtitre plates (MTP's).
- modified SPA sintillation proximity assay
- the test volume is 100 ⁇ l and contains 20 mM Tris buffer (pH 7.4), 0.1 mg of BSA (bovine serum albumin)/ml, 5 mM Mg 2+ , 0.5 ⁇ M cAMP (including about 50,000 cpm of [3H]cAMP), 1 ⁇ l of the respective substance dilution in DMSO and sufficient recombinant PDE (1000 ⁇ g supernatant, see above) to ensure that 10-20% of the cAMP is converted under the said experimental conditions.
- the final concentration of DMSO in the assays (1 % v/v) does not substantially affect the activity of the PDEs investigated.
- the reaction is started by adding the substrate (cAMP) and the assays are incubated for a further 15 min; after that, they are stopped by adding SPA beads (50 ⁇ l).
- the SPA beads had previously been resuspended in water, but were then diluted 1 :3 (v/v) in water; the diluted solution also contains 3 mM IBMX to ensure a complete PDE activity stop.
- the MTP's are analyzed in commercially available luminescence detection devices.
- the corresponding IC 50 values of the compounds for the inhibition of PDE activities are determined from the concentration-effect curves by means of non-linear regression.
- inhibitory concentrations [inhibitory concentrations as -log IC 50 (mol/l)] according to section "Method for measuring inhibition of PDE3 and PDE4 activities" are indicated for a number of compounds according to the invention for the PDE3 and the PDE4 isoenzyme.
- the number of the compounds corresponds to the numbers of the examples in the section End products.
- the inhibitory concentrations of the compounds 1-7 and 14-28 have been determined according to the above-described Method A.
- the inhibitory concentrations of the compounds 8-13 have been determined according to the above described Method B.
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Inverter Devices (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Description
Claims
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
YUP-2005/0117A RS20050117A (en) | 2002-08-17 | 2003-08-13 | Novel benzonaphthyridines |
US10/524,638 US20060113968A1 (en) | 2002-08-17 | 2003-08-13 | Novel benzonaphthyridines |
AU2003263216A AU2003263216A1 (en) | 2002-08-17 | 2003-08-13 | Benzonaphthyridines with PDE 3/4 inhibiting activity |
EP03792314A EP1581533A2 (en) | 2002-08-17 | 2003-08-13 | Novel benzonaphthyridines |
JP2004530142A JP2005537313A (en) | 2002-08-17 | 2003-08-13 | New benzonaphthyridine |
CA002495603A CA2495603A1 (en) | 2002-08-17 | 2003-08-13 | Benzonaphthyridines with pde 3/4 inhibiting activity |
IS7729A IS7729A (en) | 2002-08-17 | 2005-03-08 | Benzonyridine with PDE 3/4 inhibitory activity |
HR20050227A HRP20050227A2 (en) | 2002-08-17 | 2005-03-09 | Novel benzonaphthyridines |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02018529 | 2002-08-17 | ||
EP02018529.4 | 2002-08-17 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2004018465A2 true WO2004018465A2 (en) | 2004-03-04 |
WO2004018465A3 WO2004018465A3 (en) | 2004-05-27 |
WO2004018465A9 WO2004018465A9 (en) | 2005-09-15 |
Family
ID=31896838
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2003/008996 WO2004018465A2 (en) | 2002-08-17 | 2003-08-13 | Benzonaphthyridines with pde 3/4 inhibiting activity |
Country Status (10)
Country | Link |
---|---|
US (1) | US20060113968A1 (en) |
EP (1) | EP1581533A2 (en) |
JP (1) | JP2005537313A (en) |
AU (1) | AU2003263216A1 (en) |
CA (1) | CA2495603A1 (en) |
HR (1) | HRP20050227A2 (en) |
IS (1) | IS7729A (en) |
PL (1) | PL373598A1 (en) |
RS (1) | RS20050117A (en) |
WO (1) | WO2004018465A2 (en) |
Cited By (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006056471A1 (en) | 2004-11-29 | 2006-06-01 | Novartis Ag | 5-hydroxy-benzothiazole derivatives having beta-2-adrenorecptor agonist activity |
WO2007071400A1 (en) | 2005-12-22 | 2007-06-28 | Novartis Ag | Pyrazine derivatives as epithelial sodium channel blocker |
WO2007121920A2 (en) | 2006-04-21 | 2007-11-01 | Novartis Ag | Purine derivatives for use as adenosin a2a receptor agonists |
WO2008037477A1 (en) | 2006-09-29 | 2008-04-03 | Novartis Ag | Pyrazolopyrimidines as p13k lipid kinase inhibitors |
WO2008052734A1 (en) | 2006-10-30 | 2008-05-08 | Novartis Ag | Heterocyclic compounds as antiinflammatory agents |
US7470704B2 (en) | 2002-09-04 | 2008-12-30 | Nycomed Gmbh | Benzonaphthyridines |
WO2009087224A1 (en) | 2008-01-11 | 2009-07-16 | Novartis Ag | Pyrimidines as kinase inhibitors |
WO2009150137A2 (en) | 2008-06-10 | 2009-12-17 | Novartis Ag | Organic compounds |
US7718668B2 (en) | 2005-03-02 | 2010-05-18 | Nycomed Gmbh | Salts of 6-heterocycle substituted hexahydrophenanthridine derivatives |
EP2206499A1 (en) | 2004-11-02 | 2010-07-14 | Novartis AG | Quinuclidine derivatives and their use as muscarinic m3 receptor antagonists |
WO2010088335A1 (en) | 2009-01-29 | 2010-08-05 | Novartis Ag | Substituted benzimidazoles for the treatment of astrocytomas |
EP2253612A1 (en) | 2005-04-14 | 2010-11-24 | Novartis AG | Organic compounds |
EP2270008A1 (en) | 2005-05-20 | 2011-01-05 | Novartis AG | 1,3-dihydro-imidazo[4,5-c]quinolin-2-ones as lipid kinase and/or pi3 kinases inhibitors |
EP2279777A2 (en) | 2007-01-10 | 2011-02-02 | Irm Llc | Compounds and compositions as channel activating protease inhibitors |
EP2281819A1 (en) | 2004-01-21 | 2011-02-09 | Novartis AG | Benzimidazolyl or benzoxazolyl derivatives |
WO2011015652A1 (en) | 2009-08-07 | 2011-02-10 | Novartis Ag | 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives as c-met tyrosine kinase modulators |
WO2011018454A1 (en) | 2009-08-12 | 2011-02-17 | Novartis Ag | Heterocyclic hydrazone compounds and their uses to treat cancer and inflammation |
EP2286813A2 (en) | 2006-01-31 | 2011-02-23 | Novartis AG | Use of naphthyridine derivatives as medicaments |
WO2011020861A1 (en) | 2009-08-20 | 2011-02-24 | Novartis Ag | Heterocyclic oxime compounds |
WO2011022439A1 (en) | 2009-08-17 | 2011-02-24 | Intellikine, Inc. | Heterocyclic compounds and uses thereof |
EP2292619A1 (en) | 2004-10-22 | 2011-03-09 | Novartis AG | Purine derivatives for use as adenonsin A-2A receptor agonists |
WO2011050325A1 (en) | 2009-10-22 | 2011-04-28 | Vertex Pharmaceuticals Incorporated | Compositions for treatment of cystic fibrosis and other chronic diseases |
EP2332933A1 (en) | 2007-05-07 | 2011-06-15 | Novartis AG | Epithelial sodium channel (ENaC) inhibitors |
US8003798B2 (en) | 2004-03-03 | 2011-08-23 | Nycomed Gmbh | Hydroxy-6-heteroarylphenanthridines and their use as PDE4 inhibitors |
WO2011113894A1 (en) | 2010-03-19 | 2011-09-22 | Novartis Ag | Pyridine and pyrazine derivative for the treatment of cf |
WO2012034091A1 (en) | 2010-09-09 | 2012-03-15 | Irm Llc | Imidazo [1, 2] pyridazin compounds and compositions as trk inhibitors |
WO2012034095A1 (en) | 2010-09-09 | 2012-03-15 | Irm Llc | Compounds and compositions as trk inhibitors |
WO2012035158A1 (en) | 2010-09-17 | 2012-03-22 | Novartis Ag | Pyrazine derivatives as enac blockers |
EP2444120A1 (en) | 2007-12-10 | 2012-04-25 | Novartis AG | Spirocyclic amiloride analogues as ENac blockers |
WO2012107500A1 (en) | 2011-02-10 | 2012-08-16 | Novartis Ag | [1, 2, 4] triazolo [4, 3 -b] pyridazine compounds as inhibitors of the c-met tyrosine kinase |
WO2012116217A1 (en) | 2011-02-25 | 2012-08-30 | Irm Llc | Compounds and compositions as trk inhibitors |
WO2012116237A2 (en) | 2011-02-23 | 2012-08-30 | Intellikine, Llc | Heterocyclic compounds and uses thereof |
EP2532679A1 (en) | 2005-10-21 | 2012-12-12 | Novartis AG | Human antibodies against il13 and therapeutic uses |
WO2013030802A1 (en) | 2011-09-01 | 2013-03-07 | Novartis Ag | Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension |
WO2013038381A1 (en) | 2011-09-16 | 2013-03-21 | Novartis Ag | Pyridine/pyrazine amide derivatives |
WO2013038362A1 (en) | 2011-09-15 | 2013-03-21 | Novartis Ag | 6 - substituted 3 - (quinolin- 6 - ylthio) - [1,2,4] triazolo [4, 3 -a] pyradines as tyrosine kinase |
WO2013038373A1 (en) | 2011-09-16 | 2013-03-21 | Novartis Ag | Pyridine amide derivatives |
WO2013038390A1 (en) | 2011-09-16 | 2013-03-21 | Novartis Ag | N-substituted heterocyclyl carboxamides |
WO2013038386A1 (en) | 2011-09-16 | 2013-03-21 | Novartis Ag | Heterocyclic compounds for the treatment of cystic fibrosis |
WO2013038378A1 (en) | 2011-09-16 | 2013-03-21 | Novartis Ag | Pyridine amide derivatives |
WO2013140319A1 (en) | 2012-03-19 | 2013-09-26 | Novartis Ag | Crystalline form of a succinate salt |
WO2013149581A1 (en) | 2012-04-03 | 2013-10-10 | Novartis Ag | Combination products with tyrosine kinase inhibitors and their use |
WO2014132220A1 (en) | 2013-03-01 | 2014-09-04 | Novartis Ag | Solid forms of bicyclic heterocyclic derivatives as pdgf receptor mediators |
WO2014151147A1 (en) | 2013-03-15 | 2014-09-25 | Intellikine, Llc | Combination of kinase inhibitors and uses thereof |
WO2015084804A1 (en) | 2013-12-03 | 2015-06-11 | Novartis Ag | Combination of mdm2 inhibitor and braf inhibitor and their use |
WO2015162459A1 (en) | 2014-04-24 | 2015-10-29 | Novartis Ag | Amino pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors |
WO2015162456A1 (en) | 2014-04-24 | 2015-10-29 | Novartis Ag | Amino pyridine derivatives as phosphatidylinositol 3-kinase inhibitors |
WO2015162461A1 (en) | 2014-04-24 | 2015-10-29 | Novartis Ag | Pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors |
WO2016011956A1 (en) | 2014-07-25 | 2016-01-28 | Novartis Ag | Combination therapy |
WO2016016822A1 (en) | 2014-07-31 | 2016-02-04 | Novartis Ag | Combination therapy |
WO2018069210A1 (en) | 2016-10-10 | 2018-04-19 | Takeda Gmbh | Tetrahydrofuro[3,4-c]isoquinolines as inhibitors of pde4 |
EP3603634A1 (en) | 2004-05-18 | 2020-02-05 | Novartis AG | Pharmaceutical composition containing glycopyrrolate and a beta2 adrenoceptor agonist |
WO2020250116A1 (en) | 2019-06-10 | 2020-12-17 | Novartis Ag | Pyridine and pyrazine derivative for the treatment of cf, copd, and bronchiectasis |
WO2021038426A1 (en) | 2019-08-28 | 2021-03-04 | Novartis Ag | Substituted 1,3-phenyl heteroaryl derivatives and their use in the treatment of disease |
US11174223B2 (en) | 2010-05-11 | 2021-11-16 | Lantheus Medical Imaging, Inc. | Compositions, methods, and systems for the synthesis and use of imaging agents |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2005223386A1 (en) * | 2004-03-17 | 2005-09-29 | Nycomed Gmbh | Novel N- (alkoxyalkyl) carbamoyl - substituted 6-phenyl-benzonaphthyridine derivatives and their use as PDE3/4 inhibitors |
DE102005047551A1 (en) * | 2005-09-30 | 2007-04-12 | Siemens Ag | Exciter device for an electrical machine |
EP2549638A1 (en) * | 2011-07-19 | 2013-01-23 | AEG Power Solutions B.V. | Power supply assembly for a reactor for polysilicon production with a frequency converter |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0490823A1 (en) * | 1990-12-13 | 1992-06-17 | Sandoz Ltd. | Dihydro-isoquinoline derivates |
WO1998021208A1 (en) * | 1996-11-11 | 1998-05-22 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Benzonaphthyridines as bronchial therapeutics |
WO1999057118A1 (en) * | 1998-05-05 | 1999-11-11 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Novel n-oxides |
WO2002066476A1 (en) * | 2001-02-21 | 2002-08-29 | Altana Pharma Ag | 6-phenylbenzonaphthyridines |
EP1270577A1 (en) * | 2000-03-23 | 2003-01-02 | Takeda Chemical Industries, Ltd. | Furoisoquinoline derivatives, process for producing the same and use thereof |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU6825898A (en) * | 1997-03-07 | 1998-09-29 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Novel tetrazoles |
ATE269331T1 (en) * | 1998-08-31 | 2004-07-15 | Altana Pharma Ag | BENZONAPHTHYRIDINE N-OXIDES WITH PDE3 AND PDE4 INHIBITING ACTIVITY |
-
2003
- 2003-08-13 US US10/524,638 patent/US20060113968A1/en not_active Abandoned
- 2003-08-13 RS YUP-2005/0117A patent/RS20050117A/en unknown
- 2003-08-13 JP JP2004530142A patent/JP2005537313A/en not_active Withdrawn
- 2003-08-13 EP EP03792314A patent/EP1581533A2/en not_active Withdrawn
- 2003-08-13 PL PL03373598A patent/PL373598A1/en not_active Application Discontinuation
- 2003-08-13 AU AU2003263216A patent/AU2003263216A1/en not_active Abandoned
- 2003-08-13 WO PCT/EP2003/008996 patent/WO2004018465A2/en active Application Filing
- 2003-08-13 CA CA002495603A patent/CA2495603A1/en not_active Abandoned
-
2005
- 2005-03-08 IS IS7729A patent/IS7729A/en unknown
- 2005-03-09 HR HR20050227A patent/HRP20050227A2/en not_active Application Discontinuation
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0490823A1 (en) * | 1990-12-13 | 1992-06-17 | Sandoz Ltd. | Dihydro-isoquinoline derivates |
WO1998021208A1 (en) * | 1996-11-11 | 1998-05-22 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Benzonaphthyridines as bronchial therapeutics |
WO1999057118A1 (en) * | 1998-05-05 | 1999-11-11 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Novel n-oxides |
EP1270577A1 (en) * | 2000-03-23 | 2003-01-02 | Takeda Chemical Industries, Ltd. | Furoisoquinoline derivatives, process for producing the same and use thereof |
WO2002066476A1 (en) * | 2001-02-21 | 2002-08-29 | Altana Pharma Ag | 6-phenylbenzonaphthyridines |
Cited By (74)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8198295B2 (en) | 2002-09-04 | 2012-06-12 | Nycomed Gmbh | Benzonaphthyridines |
US7470704B2 (en) | 2002-09-04 | 2008-12-30 | Nycomed Gmbh | Benzonaphthyridines |
EP2281819A1 (en) | 2004-01-21 | 2011-02-09 | Novartis AG | Benzimidazolyl or benzoxazolyl derivatives |
US9387205B2 (en) | 2004-03-03 | 2016-07-12 | Takeda Gmbh | Hydroxy-6-heteroarylphenanthridines and their use as PDE4 inhibitors |
US8455653B2 (en) | 2004-03-03 | 2013-06-04 | Takeda Gmbh | Hydroxy-6-heteroarylphenanthridines and their use as PDE4 inhibitors |
US8318944B2 (en) | 2004-03-03 | 2012-11-27 | Nycomed Gmbh | Hydroxy-6-heteroarylphenanthridines and their use as PDE4 inhibitors |
US8883818B2 (en) | 2004-03-03 | 2014-11-11 | Takeda Gmbh | Hydroxy-6-heteroarylphenanthridines and their use as PDE4 inhibitors |
US9149479B2 (en) | 2004-03-03 | 2015-10-06 | Takeda Gmbh | Hydroxy-6-heteroarylphenanthridines and their use as PDE4 inhibitors |
US8003798B2 (en) | 2004-03-03 | 2011-08-23 | Nycomed Gmbh | Hydroxy-6-heteroarylphenanthridines and their use as PDE4 inhibitors |
US9962377B2 (en) | 2004-03-03 | 2018-05-08 | Takeda Gmbh | Hydroxy-6-heteroarylphenanthridines and their use as PDE4 inhibitors |
US8324391B2 (en) | 2004-03-03 | 2012-12-04 | Nycomed Gmbh | Hydroxy-6-heteroarylphenanthridines and their use as PDE4 inhibitors |
EP3603634A1 (en) | 2004-05-18 | 2020-02-05 | Novartis AG | Pharmaceutical composition containing glycopyrrolate and a beta2 adrenoceptor agonist |
EP2292619A1 (en) | 2004-10-22 | 2011-03-09 | Novartis AG | Purine derivatives for use as adenonsin A-2A receptor agonists |
EP2206499A1 (en) | 2004-11-02 | 2010-07-14 | Novartis AG | Quinuclidine derivatives and their use as muscarinic m3 receptor antagonists |
EP2305659A1 (en) | 2004-11-29 | 2011-04-06 | Novartis AG | 5-hydroxy-benzothiazole derivatives having beta-2-adrenoreceptor agonist activity |
WO2006056471A1 (en) | 2004-11-29 | 2006-06-01 | Novartis Ag | 5-hydroxy-benzothiazole derivatives having beta-2-adrenorecptor agonist activity |
US8829189B2 (en) | 2005-03-02 | 2014-09-09 | Takeda Gmbh | Salts of 6-heterocycle substituted hexahydrophenanthridine derivatives |
US8354535B2 (en) | 2005-03-02 | 2013-01-15 | Nycomed Gmbh | Salts of 6-heterocycle substituted hexahydrophenanthridine derivatives |
US8754218B2 (en) | 2005-03-02 | 2014-06-17 | Takeda Gmbh | Salts of 6-heterocycle substituted hexahydrophenanthridine derivatives |
US7718668B2 (en) | 2005-03-02 | 2010-05-18 | Nycomed Gmbh | Salts of 6-heterocycle substituted hexahydrophenanthridine derivatives |
EP2253612A1 (en) | 2005-04-14 | 2010-11-24 | Novartis AG | Organic compounds |
EP2270008A1 (en) | 2005-05-20 | 2011-01-05 | Novartis AG | 1,3-dihydro-imidazo[4,5-c]quinolin-2-ones as lipid kinase and/or pi3 kinases inhibitors |
EP2292617A1 (en) | 2005-05-20 | 2011-03-09 | Novartis AG | 1,3-dihydro-imidazo[4,5-c]quinolin-2-ones as lipid kinase and/or pi3 kinase inhibitors |
EP2532677A1 (en) | 2005-10-21 | 2012-12-12 | Novartis AG | Human antibodies against il13 and therapeutic uses |
EP2532679A1 (en) | 2005-10-21 | 2012-12-12 | Novartis AG | Human antibodies against il13 and therapeutic uses |
WO2007071400A1 (en) | 2005-12-22 | 2007-06-28 | Novartis Ag | Pyrazine derivatives as epithelial sodium channel blocker |
EP2286813A2 (en) | 2006-01-31 | 2011-02-23 | Novartis AG | Use of naphthyridine derivatives as medicaments |
EP2322525A1 (en) | 2006-04-21 | 2011-05-18 | Novartis AG | Purine derivatives for use as adenosin A2A receptor agonists |
WO2007121920A2 (en) | 2006-04-21 | 2007-11-01 | Novartis Ag | Purine derivatives for use as adenosin a2a receptor agonists |
WO2008037477A1 (en) | 2006-09-29 | 2008-04-03 | Novartis Ag | Pyrazolopyrimidines as p13k lipid kinase inhibitors |
WO2008052734A1 (en) | 2006-10-30 | 2008-05-08 | Novartis Ag | Heterocyclic compounds as antiinflammatory agents |
EP2279777A2 (en) | 2007-01-10 | 2011-02-02 | Irm Llc | Compounds and compositions as channel activating protease inhibitors |
EP2332933A1 (en) | 2007-05-07 | 2011-06-15 | Novartis AG | Epithelial sodium channel (ENaC) inhibitors |
EP2444120A1 (en) | 2007-12-10 | 2012-04-25 | Novartis AG | Spirocyclic amiloride analogues as ENac blockers |
EP2520574A1 (en) | 2007-12-10 | 2012-11-07 | Novartis AG | Amiloride analogues substituted on the cyclic guanidine moiety as ENaC blockers for treating respiratory diseases |
WO2009087224A1 (en) | 2008-01-11 | 2009-07-16 | Novartis Ag | Pyrimidines as kinase inhibitors |
WO2009150137A2 (en) | 2008-06-10 | 2009-12-17 | Novartis Ag | Organic compounds |
WO2010088335A1 (en) | 2009-01-29 | 2010-08-05 | Novartis Ag | Substituted benzimidazoles for the treatment of astrocytomas |
WO2011015652A1 (en) | 2009-08-07 | 2011-02-10 | Novartis Ag | 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives as c-met tyrosine kinase modulators |
WO2011018454A1 (en) | 2009-08-12 | 2011-02-17 | Novartis Ag | Heterocyclic hydrazone compounds and their uses to treat cancer and inflammation |
WO2011022439A1 (en) | 2009-08-17 | 2011-02-24 | Intellikine, Inc. | Heterocyclic compounds and uses thereof |
WO2011020861A1 (en) | 2009-08-20 | 2011-02-24 | Novartis Ag | Heterocyclic oxime compounds |
WO2011050325A1 (en) | 2009-10-22 | 2011-04-28 | Vertex Pharmaceuticals Incorporated | Compositions for treatment of cystic fibrosis and other chronic diseases |
EP2813227A1 (en) | 2009-10-22 | 2014-12-17 | Vertex Pharmaceuticals Incorporated | Compositions for treatment of cystic fibrosis and other chronic diseases |
WO2011113894A1 (en) | 2010-03-19 | 2011-09-22 | Novartis Ag | Pyridine and pyrazine derivative for the treatment of cf |
EP2845593A1 (en) | 2010-03-19 | 2015-03-11 | Novartis AG | Pyridine and pyrazine derivative for the treatment of chronic obstructive pulmonary disease |
US11174223B2 (en) | 2010-05-11 | 2021-11-16 | Lantheus Medical Imaging, Inc. | Compositions, methods, and systems for the synthesis and use of imaging agents |
WO2012034091A1 (en) | 2010-09-09 | 2012-03-15 | Irm Llc | Imidazo [1, 2] pyridazin compounds and compositions as trk inhibitors |
WO2012034095A1 (en) | 2010-09-09 | 2012-03-15 | Irm Llc | Compounds and compositions as trk inhibitors |
WO2012035158A1 (en) | 2010-09-17 | 2012-03-22 | Novartis Ag | Pyrazine derivatives as enac blockers |
WO2012107500A1 (en) | 2011-02-10 | 2012-08-16 | Novartis Ag | [1, 2, 4] triazolo [4, 3 -b] pyridazine compounds as inhibitors of the c-met tyrosine kinase |
US9127000B2 (en) | 2011-02-23 | 2015-09-08 | Intellikine, LLC. | Heterocyclic compounds and uses thereof |
WO2012116237A2 (en) | 2011-02-23 | 2012-08-30 | Intellikine, Llc | Heterocyclic compounds and uses thereof |
WO2012116217A1 (en) | 2011-02-25 | 2012-08-30 | Irm Llc | Compounds and compositions as trk inhibitors |
WO2013030802A1 (en) | 2011-09-01 | 2013-03-07 | Novartis Ag | Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension |
WO2013038362A1 (en) | 2011-09-15 | 2013-03-21 | Novartis Ag | 6 - substituted 3 - (quinolin- 6 - ylthio) - [1,2,4] triazolo [4, 3 -a] pyradines as tyrosine kinase |
WO2013038373A1 (en) | 2011-09-16 | 2013-03-21 | Novartis Ag | Pyridine amide derivatives |
WO2013038378A1 (en) | 2011-09-16 | 2013-03-21 | Novartis Ag | Pyridine amide derivatives |
WO2013038386A1 (en) | 2011-09-16 | 2013-03-21 | Novartis Ag | Heterocyclic compounds for the treatment of cystic fibrosis |
WO2013038390A1 (en) | 2011-09-16 | 2013-03-21 | Novartis Ag | N-substituted heterocyclyl carboxamides |
WO2013038381A1 (en) | 2011-09-16 | 2013-03-21 | Novartis Ag | Pyridine/pyrazine amide derivatives |
WO2013140319A1 (en) | 2012-03-19 | 2013-09-26 | Novartis Ag | Crystalline form of a succinate salt |
WO2013149581A1 (en) | 2012-04-03 | 2013-10-10 | Novartis Ag | Combination products with tyrosine kinase inhibitors and their use |
WO2014132220A1 (en) | 2013-03-01 | 2014-09-04 | Novartis Ag | Solid forms of bicyclic heterocyclic derivatives as pdgf receptor mediators |
WO2014151147A1 (en) | 2013-03-15 | 2014-09-25 | Intellikine, Llc | Combination of kinase inhibitors and uses thereof |
WO2015084804A1 (en) | 2013-12-03 | 2015-06-11 | Novartis Ag | Combination of mdm2 inhibitor and braf inhibitor and their use |
WO2015162461A1 (en) | 2014-04-24 | 2015-10-29 | Novartis Ag | Pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors |
WO2015162456A1 (en) | 2014-04-24 | 2015-10-29 | Novartis Ag | Amino pyridine derivatives as phosphatidylinositol 3-kinase inhibitors |
WO2015162459A1 (en) | 2014-04-24 | 2015-10-29 | Novartis Ag | Amino pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors |
WO2016011956A1 (en) | 2014-07-25 | 2016-01-28 | Novartis Ag | Combination therapy |
WO2016016822A1 (en) | 2014-07-31 | 2016-02-04 | Novartis Ag | Combination therapy |
WO2018069210A1 (en) | 2016-10-10 | 2018-04-19 | Takeda Gmbh | Tetrahydrofuro[3,4-c]isoquinolines as inhibitors of pde4 |
WO2020250116A1 (en) | 2019-06-10 | 2020-12-17 | Novartis Ag | Pyridine and pyrazine derivative for the treatment of cf, copd, and bronchiectasis |
WO2021038426A1 (en) | 2019-08-28 | 2021-03-04 | Novartis Ag | Substituted 1,3-phenyl heteroaryl derivatives and their use in the treatment of disease |
Also Published As
Publication number | Publication date |
---|---|
US20060113968A1 (en) | 2006-06-01 |
JP2005537313A (en) | 2005-12-08 |
HRP20050227A2 (en) | 2006-06-30 |
CA2495603A1 (en) | 2004-03-04 |
WO2004018465A3 (en) | 2004-05-27 |
RS20050117A (en) | 2007-06-04 |
PL373598A1 (en) | 2005-09-05 |
EP1581533A2 (en) | 2005-10-05 |
WO2004018465A9 (en) | 2005-09-15 |
AU2003263216A1 (en) | 2004-03-11 |
IS7729A (en) | 2005-03-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP1581533A2 (en) | Novel benzonaphthyridines | |
US6306869B1 (en) | N-oxides | |
US20060116518A1 (en) | Novel phenanthridines | |
US20060167001A1 (en) | Pyridazinone-derivatives as pde4 inhibitors | |
AU2005212857B2 (en) | Novel guanidinyl-substituted hydroxy-6-phenylphenenthridines as effective phosphodiesterase (PDE) 4 inhibitors | |
US7671068B2 (en) | N-(alkoxyalkyl) carbamoyl-substituted 6-phenyl-benzonaphthyridine derivatives and their use as PDE ¾ inhibitors | |
EP1377574B1 (en) | 6-phenylbenzonaphthyridines | |
WO2002005616A1 (en) | Novel 6-phenylphenanthridines | |
AU2002253045A1 (en) | 6-phenylbenzonaphthyridines | |
US20080119505A1 (en) | Novel 6-Pyridylphenanthridines | |
EP1537109B1 (en) | Novel benzonaphthyridines |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
WWE | Wipo information: entry into national phase |
Ref document number: P-2005/0117 Country of ref document: YU |
|
AK | Designated states |
Kind code of ref document: A2 Designated state(s): AE AL AU BA BR CA CN CO DZ EC GE HR ID IL IN IS JP KR LT LV MA MK MX NO NZ PH PL SG TN UA US VN YU ZA ZW |
|
AL | Designated countries for regional patents |
Kind code of ref document: A2 Designated state(s): AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PT RO SE SI SK TR |
|
121 | Ep: the epo has been informed by wipo that ep was designated in this application | ||
ENP | Entry into the national phase |
Ref document number: 2495603 Country of ref document: CA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 373598 Country of ref document: PL |
|
ENP | Entry into the national phase |
Ref document number: 2006113968 Country of ref document: US Kind code of ref document: A1 |
|
WWE | Wipo information: entry into national phase |
Ref document number: 10524638 Country of ref document: US |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2004530142 Country of ref document: JP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2003792314 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: P20050227A Country of ref document: HR |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2003263216 Country of ref document: AU |
|
COP | Corrected version of pamphlet |
Free format text: PUBLISHED INTERNATIONAL SEARCH REPORT (1 PAGE) REPLACED BY CORRECT INTERNATIONAL SEARCH REPORT (4 PAGES) |
|
WWP | Wipo information: published in national office |
Ref document number: 2003792314 Country of ref document: EP |
|
WWP | Wipo information: published in national office |
Ref document number: 10524638 Country of ref document: US |